Neurodevelopmental Effects of Early Life Arsenic Exposure

生命早期砷暴露对神经发育的影响

• 批准号: 8473216
• 负责人: Maitreyi Mazumdar
• 金额: $ 13.89万
• 依托单位: BOSTON CHILDREN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-09-01 至 2014-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8473216
• 关键词: Adult; Affect; Age; Age-Months; Area; Argentina; Arsenic; Auditory Brainstem Responses; Australia; Award; Bangladesh; Biometry; Birth; Boston; Characteristics; Child; Chile; China; Chronic; Clinic; Clinical Research; Cohort Studies; Communities; Country; Cross-Sectional Studies; Data; Development; Development Plans; Diabetes Mellitus; Educational process of instructing; Elements; Environmental Epidemiology; Environmental Health; Environmental Pollution; Environmental Risk Factor; Epidemiologic Studies; Epidemiology; Evaluation; Exposure to; Failure; Fellowship; Foundations; Functional disorder; Goals; Guidelines; Hair; Head circumference; Health; Health Surveys; Hearing; India; Infant; Instruction; Investigation; Life; Link; Measures; Mentors; Mentorship; Metals; Mexico; Microcephaly; Mongolia; Mothers; Motor; Nervous System Trauma; Neurodevelopmental Disorder; Neurologic; Neurology; Outcome; Participant; Pediatric Hospitals; Peripheral Vascular Diseases; Poisoning; Population; Principal Investigator; Public Health Schools; Recording of previous events; Recruitment Activity; Reporting; Reproductive Health; Research; Research Personnel; Risk; Risk Assessment; Role; School-Age Population; Skin Cancer; Structure; Structure of nail of toe; Taiwan; Thailand; Toxic effect; Toxicology; United States; Vietnam; Water; Work; World Health Organization; career; career development; cohort; design; didactic education; drinking water; early childhood; early life exposure; experience; hearing impairment; high risk; high risk drinking; improved; infancy; instructor; interest; medical schools; meetings; method development; nervous system disorder; neurocognitive test; neurodevelopment; patient oriented research; population based; prenatal; professor; programs; prospective; reproductive; research and development; skin lesion; water sampling/testing

Dr. Maitreyi Mazumdar is Assistant In Neurology at Children's Hospital Boston and Instructor In Neurology at Harvard Medical School. The candidate's long-term goal is to develop an Independent research career focusing on the role of environmental contaminants in the development of neurological Injury and disease In children. Dr. Mazumdar's Interests in this field developed during her Fellowship in neurodevelopmental toxicology, when she became aware of Investigations of the effects of environmental arsenic exposure on children in Bangladesh. The proposed career development plan incorporates a multi-disciplinary program designed to provide an Intense, closely mentored, patient-oriented research experience, associated with a comprehensively structured didactic curriculum In environmental epidemiology, exposure assessment, advanced biostatistics, and risk-assessment. Under the mentorship of Dr. David Christiani, Professor of Environmental Health at the Harvard School of Public Health, the candidate will investigate the effect of prenatal and early childhood arsenic exposure on neurodevelopment of children In Bangladesh, a country with high levels of arsenic contamination In groundwater. This research will examine epidemiological associations of arsenic exposure with measures of neurological development In infants and children, including 1) head circumference, 2) hearing impairment, 3) motor dysfunction, and 4) formal neurocognitive testing. The studies will be conducted in a cohort of 600 infants who are participating In a current study of reproductive health effects of arsenic. Additional children between the ages of 12 and 24 months wlll also be recruited neurodevelopmental assessment. The superb clinical, research, and teaching facilities of Children's Hospital Boston, Harvard Medical School, and the Harvard School of Public Health will support Dr. Mazumdar in meeting the objectives of her career development and research plans.

Maitreyi Mazumdar博士是波士顿儿童医院神经学助理和神经学讲师 哈佛医学院。候选人的长期目标是发展独立研究事业 关注环境污染物在神经损伤和疾病发展中的作用 孩子们。Mazumdar博士对这一领域的兴趣是在她担任神经发育研究员期间产生的 毒理学，当她意识到环境砷暴露对人体健康影响的调查 孟加拉的儿童。拟议的职业发展计划包含一个多学科方案。 旨在提供紧张、密切指导、以患者为中心的研究体验，与 环境流行病学、暴露评估、 高级生物统计学和风险评估。在大卫·克里斯汀尼博士的指导下， 哈佛大学公共卫生学院的环境健康，候选人将调查 孟加拉国产前和儿童早期砷暴露对儿童神经发育的影响 地下水中砷污染水平很高。这项研究将检查流行病学 砷暴露与婴儿和儿童神经发育指标的关系， 包括1)头围，2)听力障碍，3)运动障碍，4)正式神经认知 测试。这些研究将在600名婴儿中进行，他们参与了目前的一项研究 砷对生殖健康的影响。12至24个月之间的额外儿童也将 招募神经发育评估。一流的临床、研究和教学设施 波士顿儿童医院、哈佛医学院和哈佛公共卫生学院将为Dr。 Mazumdar在实现她的职业发展和研究计划的目标方面发挥了重要作用。

项目成果

Journal club: pretreatment EEG in childhood absence epilepsy.

期刊俱乐部：儿童失神性癫痫的预处理脑电图。

• DOI: 10.1212/wnl.0000000000000380
• 发表时间: 2014
• 期刊: Neurology
• 影响因子: 9.9
• 作者: Bernson-Leung,MiyaE;Mazumdar,Maitreyi
• 通讯作者: Mazumdar,Maitreyi

Prenatal lead levels, plasma amyloid β levels, and gene expression in young adulthood.

• DOI: 10.1289/ehp.1104474
• 发表时间: 2012-05
• 期刊: Environmental health perspectives
• 影响因子: 10.4
• 作者: Mazumdar M;Xia W;Hofmann O;Gregas M;Ho Sui S;Hide W;Yang T;Needleman HL;Bellinger DC
• 通讯作者: Bellinger DC