Nutrition and Superfund Chemical Toxicity

营养和超级基金化学毒性

• 批准号: 8249969
• 负责人: BERNHARD HENNIG
• 金额: $ 209.5万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 1997
• 资助国家: 美国
• 起止时间: 1997-04-07 至 2014-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8249969
• 关键词: Abdominal Aortic Aneurysm; Address; Agriculture; Biosensor; Blood Vessels; Cardiovascular Diseases; Chronic Disease; Collaborations; Community Outreach; Detection; Diet; Diet Habits; Dietary Fats; Dietary Intervention; Discipline; Disease; Drug Metabolic Detoxication; Ecosystem; Education; Environment; Environmental Pollutants; Functional disorder; Genetic; Grant; Health; Interdisciplinary Study; Intervention; Kentucky; Lead; Medicine; Neoplasm Metastasis; Nutrient; Obesity; Policies; Polychlorinated Biphenyls; Populations at Risk; Prevention strategy; Primary Prevention; Recommendation; Regimen; Research; Research Personnel; Risk; Techniques; Technology Transfer; Toxic effect; Toxicology; Training; Translational Research; Universities; college; improved; novel; nutrition; programs; remediation; superfund chemical; superfund site; toxicant interaction

The University of Kentucky is unique among land grant universities in that all colleges, including Medicine and Agriculture, are located on the same campus. This constellation of programs has enabled the UK-SBRP to develop uniquely productive collaborations across diverse disciplines. Such an environment will allow to study the overall theme of the SBRP research, which focuses on the toxicology of Superfund chemicals and how health effects of exposure can be modulated by both intrinsic and extrinsic factors, namely genetics and nutrition, respectively. Given the abundance of Superfund chemicals and widespread distribution in the ecosystem, it is unlikely that remediation alone will be sufficient to address their health risks. Nutritional intervention thus becomes a sensible way to address health problems associated with environmental pollutants. In the competing renewal, the investigators recognize this dual need for sensing/remediation and biomedical intervention through nutrition by proposing five integrated projects. The investigators will concentrate on chlorinated organics (e.g., polychlorinated biphenyls) prevalent in most Superfund sites, including those found in Kentucky. Preliminary findings by this group suggest that nutrition and dietary habits can markedly influence mechanisms of toxicity of the above-mentioned Superfund chemicals. Thus, a major objective of our SBRP is to explore the paradigm that nutrition can modify Superfund chemical toxicity. All biomedical projects will focus on chronic diseases associated with vascular dysfunction, such as cardiovascular disease, cancer metastasis, and obesity-related abdominal aortic aneurysms, and will utilize a similar dietary fat regimen to study nutrient/toxicant interactions. There will be significant cross-talk with non-biomedical projects, which will explore novel techniques for both remediation (detoxification) and biosensors associated with detection of PCBs and other chlorinated organics. Results from interdisciplinary research will be utilized for information/education, technology transfer, training, policy and translational purposes as part of the objectives of the Research Translation, Community Outreach, and Training Cores. Nutrition may be the most sensible means to develop primary prevention strategies of diseases associated with many environmental toxic insults. Thus, research proposed by the investigators may lead to novel dietary recommendations at the national level for populations at risk, thus improving the health of people residing near Superfund sites.

肯塔基大学在土地赠与大学中是独一无二的，因为包括医学和农业在内的所有学院都位于同一校区。这一系列项目使英国-SBRP能够在不同学科之间开展独一无二的富有成效的合作。这样的环境将使人们能够研究SBRP研究的总体主题，重点是超级基金化学品的毒理学，以及暴露的健康影响如何分别受到内在和外在因素的调节，即遗传和营养。考虑到超级基金化学物质的丰富和在生态系统中的广泛分布，仅靠补救措施不太可能足以解决它们的健康风险。因此，营养干预成为解决与环境污染物相关的健康问题的一种明智方式。在相互竞争的更新中，研究人员通过提出五个综合项目，认识到通过营养来感知/补救和生物医学干预的双重需求。调查人员将专注于大多数超级基金网站中普遍存在的氯有机物(例如多氯联苯)，包括在肯塔基州发现的那些网站。该小组的初步研究结果表明，营养和饮食习惯可以显著影响上述超级基金化学品的毒性机制。因此，我们SBRP的一个主要目标是探索营养可以改变Superfund化学毒性的范式。所有生物医学项目都将专注于与血管功能障碍相关的慢性疾病，如心血管疾病、癌症转移和肥胖相关的腹主动脉瘤，并将利用类似的饮食脂肪方案来研究营养/毒物的相互作用。将与非生物医学项目产生重大的相互影响，这些项目将探索与多氯联苯和其他氯化有机物检测相关的补救(解毒)和生物传感器的新技术。跨学科研究成果将用于信息/教育、技术转让、培训、政策和翻译目的，作为研究翻译、社区推广和培训核心目标的一部分。营养可能是制定与许多环境有毒侮辱相关的疾病初级预防战略的最明智的手段。因此，研究人员提出的研究可能会在国家层面上为高危人群带来新的饮食建议，从而改善居住在超级基金地点附近的人的健康。