Project Impact: A Culturally-Tailored Adherence Intervention for Latino Smokers

项目影响：针对拉丁裔吸烟者的文化定制依从干预措施

• 批准号: 8604460
• 负责人: Marcel Alejandro de Dios
• 金额: $ 14.02万
• 依托单位: UNIVERSITY OF TX MD ANDERSON CAN CTR
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-02-27 至 2017-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8604460
• 关键词: Project; Impact; Culturally; Tailored; Adherence

DESCRIPTION (provided by applicant): In 2009, tobacco use was implicated in 438,000 deaths in the U.S. and over 80% of lung cancers were attributed to smoking. Lung cancer is the primary cause of cancer death for Latino men and the second leading cause for Latina women. Several pharmacological treatments for smoking cessation have been shown to be effective at improving tobacco abstinence rates, including nicotine replacement therapy (NRT). Despite the availability of these efficacious treatments, adherence to treatment is a significant barrier for Latinos. Developing novel, effective and culturally targeted interventions that increase NRT adherence among Latinos can ultimately inform clinical practice and improve the cessation rates of Latino smokers seeking to quit. The current study seeks to develop and test a culturally tailored medication adherence intervention that will include text messaging and behavioral components that target the unique needs of Latino smokers. These novel and targeted components will address misperceptions and barriers related to NRT treatment and offer real-time reminders and informational prompts to enhance adherence. In the initial development phase of the research, qualitative methods will be used to develop the Latino-targeted components of the intervention. During the clinical trial phase of the study, 98 Latino smokers interested in quitting will be randomized to one of two groups - Culturally Tailored Adherence (CTA), or 2) Standard Medication Management (SMM). All participants will receive 12 weeks of NRT and will receive ongoing assessments of NRT adherence, tobacco abstinence, and will be assessed on the constructs of our theoretical model (e.g. motivation or behavioral skills). The proposed study will be conducted in the context of a five-year career development program that will provide advanced training in Latino-specific health interventions, adherence interventions, the use of technology in healthcare, and qualitative methodologies. The proposed training and research plans aim to promote the applicant's long-term career goal of establishing an independently-funded program of tobacco research with a focus on Latino populations, which are disproportionately impacted by addiction and its related diseases. Furthermore our short-term goal of developing and testing treatment interventions that address the unique psychosocial characteristics and needs of low-income and ethnically diverse subpopulations will be accomplished by this program of research. A comprehensive training plan is proposed, combining mentored research, structured didactic activities guided by established researchers in the field, formal coursework and workshops, and participation in seminars at Brown University and Butler Hospital.

描述（由申请人提供）：2009年，美国有43.8万人死于烟草使用，超过80%的肺癌可归因于吸烟。肺癌是拉丁裔男性癌症死亡的主要原因，也是拉丁裔女性癌症死亡的第二大原因。一些药物治疗戒烟已被证明是有效的提高戒烟率，包括尼古丁替代疗法（NRT）。尽管有这些有效的治疗方法，但对拉丁美洲人来说，坚持治疗是一个重大障碍。开发新颖、有效和有文化针对性的干预措施，增加拉丁裔人对非尼古丁替代疗法的依从性，最终可以为临床实践提供信息，并提高寻求戒烟的拉丁裔吸烟者的戒烟率。目前的研究旨在开发和测试一种适合不同文化的药物依从性干预方法，该方法将包括针对拉丁裔吸烟者独特需求的短信和行为成分。这些新颖且有针对性的组件将解决与NRT治疗相关的误解和障碍，并提供实时提醒和信息提示，以提高依从性。在研究的初始发展阶段，将使用定性方法来开发针对拉丁裔的干预成分。在研究的临床试验阶段，98名有意戒烟的拉丁裔吸烟者将被随机分为两组-文化量身定制的依从性（CTA）或2)标准药物管理（SMM）。所有参与者将接受12周的NRT，并将接受持续的NRT依从性评估，戒烟情况评估，并将评估我们的理论模型构建（例如动机或行为技能）。拟议的研究将在一个五年职业发展方案的背景下进行，该方案将提供针对拉丁裔的保健干预措施、依从性干预措施、在保健中使用技术和定性方法方面的高级培训。拟议的培训和研究计划旨在促进申请人的长期职业目标，即建立一个独立资助的烟草研究方案，重点关注受到成瘾及其相关疾病不成比例影响的拉丁裔人口。此外，我们的短期目标是开发和测试治疗干预措施，以解决低收入和种族多样化亚人群的独特心理社会特征和需求，这将通过这个研究项目来完成。提出了一项综合培训计划，包括指导研究、由该领域知名研究人员指导的结构化教学活动、正式课程和讲习班，以及参加布朗大学和巴特勒医院的研讨会。