Short Course on Experimental Models of Human Cancer

描述（由申请人提供）：癌症是一组遗传复杂且生物学异质性的疾病。越来越清楚的是，实验室小鼠是人类最好的遗传学定义的实验模型生物体，为快速了解癌症的遗传基础和潜在生物学提供了一个重要的机会。我们课程的总体目标是培训年轻科学家（博士前，博士后学员，新的研究人员）使用遗传定义的实验室小鼠作为遗传工具， 询问有关基因功能和遗传学在癌症生物学中的作用的问题。完成本课程的学生将获得以下工作知识：（1）小鼠遗传学和基因组学，（2）生长控制和癌症，（3）实验设计和统计遗传学在复杂性状分析中的应用，（4）生物信息学，（5）与小鼠一起工作的动物健康和伦理考虑，（6）基本的小鼠手术技术，以及（7）人类癌症的小鼠模型。将重点介绍小鼠如何用于基础研究向临床的转化。 这些目标将通过为35名因其杰出的研究潜力而被选中的年轻研究人员提供为期10天的强化课程来实现。他们将与一群来自杰克逊实验室和其他著名机构的著名小鼠遗传学家和癌症生物学家进行交流。班级的规模将被故意保持在较小的规模，以实现 师生互动的理想水平。该课程将于每年八月的最后两周在公海举行，杰克逊实验室的住宅海滨会议设施。讲座，讨论，研讨会和演示将在上午，下午和晚上举行，共约72小时的教学和实践培训。我们要求在此应用程序中提供整整五年的支持。 杰克逊实验室是一个国家癌症研究所指定的基础研究癌症中心，并拥有举办高级课程和科学会议的悠久历史。自1992年以来，本申请中所述的“人类癌症实验模型”年度短期课程每年举办一次。 公共卫生相关性：实验室小鼠是一种强大的遗传工具，将继续在理解癌症的遗传基础和潜在生物学以及预测新的和现有疗法的临床安全性和有效性方面发挥深远的作用。像这样的培训课程是，并将继续是，绝对需要培养高技能的年轻调查人员的骨干，这将是治愈这种疾病所需要的。

DESCRIPTION (provided by applicant): Cancer is a genetically complex and biologically heterogeneous group of disorders. It has become increasingly clear that the laboratory mouse, the best genetically defined experimental model organism for humans, presents a major opportunity for rapid advancement in understanding the genetic basis and underlying biology of cancer. The overall goal for our course is to train young scientists (predoctoral, postdoctoral trainees, new investigators) in the use of genetically defined laboratory mice as genetic tools for asking questions about gene function and the role of genetics in the biology of cancer. Students completing the course will acquire a working knowledge of: (1) mouse genetics and genomics, (2) growth control and cancer, (3) experimental design and the application of statistical genetics to complex trait analysis, (4) bioinformatics, (5) animal health and ethical considerations in working with mice, (6) basic mouse surgical techniques, and (7) mouse models for human cancer. How the mouse is used in the translation of basic research to the clinic will be emphasized. These Aims will be accomplished by offering an intensive 10-day course to 35 young investigators chosen for their outstanding research potential. They will interact with a group of prominent mouse geneticists and cancer biologists both from The Jackson Laboratory and other prominent institutions. The size of the class will be kept deliberately small in order to achieve a desirable level of student-faculty interaction. The course will be held annually during the last tw weeks of August at Highseas, The Jackson Laboratory's residential oceanfront conference facility. Lectures, discussions, workshops, and demonstrations will be held morning, afternoon, and evening for a total of approximately 72 hours of didactic and hands-on training. We are asking for a full five years of support in this application. The Jackson Laboratory is an NCI-designated Basic Research Cancer Center and has a long history of hosting advanced courses and scientific meetings. The annual short course on the "Experimental Models of Human Cancer" described in this application has been held annually since 1992. PUBLIC HEALTH RELEVANCE: The laboratory mouse is a powerful genetic tool that will continue to play a profound role in understanding the genetic basis and underlying biology of cancer, and in predicting clinical safety and efficacy of new and existing therapies. Training courses such as these are, and will continue to be, absolutely required to develop the cadre of highly skilled young investigators, that will be needed to cure this disease.