Short Course on Experimental Models of Human Cancer

描述(申请人提供)：癌症是一组基因复杂和生物异质性的疾病。越来越清楚的是，实验室小鼠是人类最好的基因定义的实验模式生物，它为理解癌症的遗传基础和潜在生物学提供了一个快速进步的重大机会。我们课程的总体目标是培训年轻的科学家(博士后、博士后实习生、新的研究人员)如何使用基因定义的实验室小鼠作为基因工具 提出关于基因功能和遗传学在癌症生物学中的作用的问题。完成课程的学生将获得以下实用知识：(1)小鼠遗传学和基因组学，(2)生长控制和癌症，(3)实验设计和统计遗传学在复杂性状分析中的应用，(4)生物信息学，(5)动物健康和与小鼠合作的伦理考虑，(6)小鼠手术的基本技术，以及(7)人类癌症的小鼠模型。将强调如何使用鼠标将基础研究转化为临床研究。 这些目标将通过向35名因其杰出的研究潜力而被选中的年轻研究人员提供为期10天的强化课程来实现。他们将与来自杰克逊实验室和其他著名机构的一群著名的老鼠遗传学家和癌症生物学家进行互动。班级的人数将被故意保持在较小的水平，以实现 理想的师生互动水平。该课程将于每年8月的最后两周在杰克逊实验室的海滨会议设施HighSea举行。讲座、讨论、工作坊和演示将在上午、下午和晚上举行，总共约72小时的授课和动手培训。我们要求在此应用程序中提供整整五年的支持。 杰克逊实验室是美国国家癌症研究所指定的基础研究癌症中心，在举办高级课程和科学会议方面有着悠久的历史。本申请中所述的年度短期课程“人类癌症实验模型”自1992年以来每年举办一次。

DESCRIPTION (provided by applicant): Cancer is a genetically complex and biologically heterogeneous group of disorders. It has become increasingly clear that the laboratory mouse, the best genetically defined experimental model organism for humans, presents a major opportunity for rapid advancement in understanding the genetic basis and underlying biology of cancer. The overall goal for our course is to train young scientists (predoctoral, postdoctoral trainees, new investigators) in the use of genetically defined laboratory mice as genetic tools for asking questions about gene function and the role of genetics in the biology of cancer. Students completing the course will acquire a working knowledge of: (1) mouse genetics and genomics, (2) growth control and cancer, (3) experimental design and the application of statistical genetics to complex trait analysis, (4) bioinformatics, (5) animal health and ethical considerations in working with mice, (6) basic mouse surgical techniques, and (7) mouse models for human cancer. How the mouse is used in the translation of basic research to the clinic will be emphasized. These Aims will be accomplished by offering an intensive 10-day course to 35 young investigators chosen for their outstanding research potential. They will interact with a group of prominent mouse geneticists and cancer biologists both from The Jackson Laboratory and other prominent institutions. The size of the class will be kept deliberately small in order to achieve a desirable level of student-faculty interaction. The course will be held annually during the last tw weeks of August at Highseas, The Jackson Laboratory's residential oceanfront conference facility. Lectures, discussions, workshops, and demonstrations will be held morning, afternoon, and evening for a total of approximately 72 hours of didactic and hands-on training. We are asking for a full five years of support in this application. The Jackson Laboratory is an NCI-designated Basic Research Cancer Center and has a long history of hosting advanced courses and scientific meetings. The annual short course on the "Experimental Models of Human Cancer" described in this application has been held annually since 1992.