Uranium as an Environmental Risk Factor for Cancer Among the Navajo

项目总结(见说明)： 背景：美洲原住民癌症预防伙伴关系的总体目标是通过研究、培训和推广计划，减轻西南部美洲原住民之间不平等的癌症负担。NACP是北亚利桑那大学和在这两所大学开发和实施的合作伙伴关系 机构。项目旨在促进美洲原住民进入生物医学研究和 卫生保健专业人员，同时让社区参与与其需求相关的研究和培训。 研究项目包括实验室、实地和社区参与性研究。全 涉及社区的计划起源于社区，并在 与NACP的学生和教职员工建立伙伴关系。 目标：1.继续提高北大癌症研究和培训的竞争地位，增加 新的癌症研究人员，并继续为所有初级教师提供强大的教师发展计划。2.至 制定计划，促进美洲原住民学生成功过渡到我们的计划和 这提高了美国原住民生物医学科学本科生的留校率和毕业率。 3.发展可持续的社区教育计划和癌症预防研究，以符合 霍皮部落以及纳瓦霍族和托霍诺奥奥德姆民族的独特需求。 方法：包括三个癌症研究项目：(1)基因和基因的作用分析 基因组不稳定中的染色体重排，(2)铀作为癌症的环境危险因素 纳瓦霍和(3)变构、蛋白质复合体和一氧化氮的细胞分布 受体，可溶性鸟苷酸环化酶。所有的研究项目都雇佣了美洲原住民学生研究人员。这个 该培训计划的目标是增加#年进入职业生涯的美洲原住民学生的数量 癌症研究和医疗保健。将实施增加新生入学人数的计划 以及部落和社区学院，本科生培训计划将是 实施的目的是为学生进入研究生研究和专业课程做准备。的目标是 外联方案是加强NAU和AZCC/UA与霍皮人、纳瓦霍人和 Tohono O‘odham部落社区增加社区癌症预防活动和癌症控制 对卫生专业人员进行培训，这将导致接受 癌症筛查。

PROJECT SUMMARY (See instructions): BACKGROUND: The overall objective of the Partnership for Native America Cancer Prevention is to alleviate the unequal burden of cancer among Native Americans of the Southwest through research, training and outreach programs. NACP is a partnership between Northern Arizona University and the developed and implemented at the two institutions. Programs are designed to facilitate the entry of Native Americans into biomedical research and health care professions while engaging communities in research and training relevant to their needs. Research projects include laboratory, field-based, and community-based participatory research. All programs involving communities originate in communities and are developed and implemented in partnership with NACP students and faculty. AIMS: 1. To continue to increase the competitive stance of cancer research and training at NAU by adding new cancer researchers and by continuing strong faculty development programs for all junior faculty. 2. To develop programs that facilitate the successful transition of Native American students into our programs and that enhance the retention and graduation of Native Americans undergraduates in biomedical sciences. 3. To develop sustainable community education programs and research for cancer prevention that meet the unique needs of the Hopi Tribe and the Navajo and Tohono O'odham Nations. METHODS: Three cancer research projects are included (1) Analysis of the roles of genes and chromosome rearrangements in genomic instability, (2) Uranium as environmental risk factor for cancer among the Navajo and (3) Allostery, Protein Complexes and Cellular Distribution for the Nitric Oxide Receptor, Soluble Guanylyl Cyclase. All research projects employ Native American student researchers. The goal of the training program is to increase the number of Native American students entering careers in cancer research and healthcare. Programs will be implemented increase the numbers of entering Freshmen and tribal and community colleges in our programs, and an undergraduate training program will be implemented to prepare students to enter graduate research and professional programs. The goal of the outreach program is to strengthen collaboration between NAU and AZCC/UA with the Hopi, Navajo and Tohono O'odham tribal communities to increase community cancer prevention activities and cancer control training for health professionals that will result in increases in the numbers of Native Americans who receive cancer screening.