Uranium as an Environmental Risk Factor for Cancer Among the Navajo

铀是纳瓦霍人癌症的环境危险因素

• 批准号: 8541629
• 负责人: TED A. WEINERT
• 金额: $ 20.86万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8541629
• 关键词: Americas; Area; Arizona; Biological Availability; Biological Models; Biomedical Research; Cancer Burden; Cancer Center; Cancer Control; Cancer Research Project; Chromosomes; Collaborations; Communities; Community Health Education; Complex; DNA Sequence Rearrangement; Environmental Risk Factor; Faculty; Genes; Genomic Instability; Goals; Health Professional; Healthcare; Institution; Instruction; Isotopes; Laboratories; Malignant Neoplasms; Measures; Mining; Mission; Native Americans; Navajo; Program Development; Research; Research Personnel; Research Project Grants; Research Training; Role; Science; Screening for cancer; Soil; Soluble Guanylate Cyclase; Source; Students; Testing; Training; Training Programs; Tribes; Universities; Uranium; Water; anticancer research; base; cancer prevention; career; community based participatory research; community college; design; meetings; outreach program; programs; protein complex; remediation; tribal college; tribal community

PROJECT SUMMARY (See instructions): BACKGROUND: The overall objective of the Partnership for Native America Cancer Prevention is to alleviate the unequal burden of cancer among Native Americans of the Southwest through research, training and outreach programs. NACP is a partnership between Northern Arizona University and the developed and implemented at the two institutions. Programs are designed to facilitate the entry of Native Americans into biomedical research and health care professions while engaging communities in research and training relevant to their needs. Research projects include laboratory, field-based, and community-based participatory research. All programs involving communities originate in communities and are developed and implemented in partnership with NACP students and faculty. AIMS: 1. To continue to increase the competitive stance of cancer research and training at NAU by adding new cancer researchers and by continuing strong faculty development programs for all junior faculty. 2. To develop programs that facilitate the successful transition of Native American students into our programs and that enhance the retention and graduation of Native Americans undergraduates in biomedical sciences. 3. To develop sustainable community education programs and research for cancer prevention that meet the unique needs of the Hopi Tribe and the Navajo and Tohono O'odham Nations. METHODS: Three cancer research projects are included (1) Analysis of the roles of genes and chromosome rearrangements in genomic instability, (2) Uranium as environmental risk factor for cancer among the Navajo and (3) Allostery, Protein Complexes and Cellular Distribution for the Nitric Oxide Receptor, Soluble Guanylyl Cyclase. All research projects employ Native American student researchers. The goal of the training program is to increase the number of Native American students entering careers in cancer research and healthcare. Programs will be implemented increase the numbers of entering Freshmen and tribal and community colleges in our programs, and an undergraduate training program will be implemented to prepare students to enter graduate research and professional programs. The goal of the outreach program is to strengthen collaboration between NAU and AZCC/UA with the Hopi, Navajo and Tohono O'odham tribal communities to increase community cancer prevention activities and cancer control training for health professionals that will result in increases in the numbers of Native Americans who receive cancer screening.

项目总结（见说明）： 背景技术背景：美洲原住民癌症预防伙伴关系的总体目标是通过研究、培训和外联方案减轻西南部美洲原住民的不平等癌症负担。NACP是北方亚利桑那大学和 制定并实施了两个 机构职能体系该计划旨在促进美洲原住民进入生物医学研究， 同时让社区参与与其需求相关的研究和培训。 研究项目包括实验室，实地和社区参与式研究。所有 涉及社区的方案源于社区，并在社区内制定和实施。 与NACP的学生和教师合作。 目标：1.继续提高NAU癌症研究和培训的竞争地位， 新的癌症研究人员，并继续为所有初级教师强有力的教师发展计划。2.到 制定计划，促进美洲原住民学生成功过渡到我们的计划， 这提高了美国原住民本科生在生物医学科学方面的保留和毕业。 3.发展可持续的社区教育计划和癌症预防研究，以满足 霍皮族、纳瓦霍族和Tohono O 'odham民族的独特需求。 方法：包括3个肿瘤研究项目：（1）基因作用分析， 基因组不稳定性中的染色体重排，（2）铀作为癌症的环境危险因素 纳瓦霍人之间的差异;（3）一氧化氮的Allostery、蛋白质复合物和细胞分布 受体，可溶性鸟苷酸环化酶。所有研究项目都雇用美国原住民学生研究人员。的 培训计划的目标是增加美国本土学生进入职业生涯的人数， 癌症研究和医疗保健将实施计划，增加新生入学人数 部落和社区学院在我们的计划，和本科培训计划将 实施，以准备学生进入研究生研究和专业课程。的目标 外展计划是加强NAU和AZCC/UA与霍皮人，纳瓦霍人和 Tohono O 'odham部落社区增加社区癌症预防活动和癌症控制 对卫生专业人员的培训，将导致接受治疗的美国原住民人数的增加， 癌症筛查