2012/2013 Enzymes, Coenzymes, and Metabolic Pathways Gordon Research Conference

描述（由申请人提供）：本提案要求2012年和2013年“酶、辅酶和代谢途径”戈登研究会议的部分支持，该会议定于2012年7月15日至20日和2013年7月在新罕布什尔州沃特维尔谷的沃特维尔谷度假村举行。本次会议的广泛和长期目标是促进对生化途径及其相关催化剂的分子水平的理解。我们的具体目标是提供一个约36人的演讲计划（从海报摘要中选择8人），描述酶机制和调控，酶和代谢工程以及代谢和遗传控制机制的最新进展。下午的海报会议为所有与会者提供了一个展示他们工作的场所，并为初级调查员提供了一个与现场高级调查员互动的机会。这一提议的意义在于，酶、辅酶和代谢途径GRC可以作为研究人员研究生物化学反应分子机制的试金石，这些反应实际上是生命的责任。这种应用与健康的关系源于这样一个事实，即疾病过程的分子描述对于化疗的设计是不可或缺的。

DESCRIPTION (provided by applicant): This proposal requests partial support of the 2012 and 2013 Gordon Research Conferences on "Enzymes, Coenzymes, and Metabolic Pathways", which are scheduled for July 15 - 20, 2012 and in July, 2013 at Waterville Valley Resort, Waterville Valley, New Hampshire. The broad and long-term goal of this conference is to foster a molecular-level understanding of biochemical pathways and their associated catalysts. Our specific aim is to present a program of ~36 speakers (8 chosen from poster abstracts), describing recent advances in enzyme mechanisms and regulation, enzyme and metabolic engineering, and the mechanisms underlying metabolic and genetic control. Afternoon poster sessions provide a venue for all attendees to present their work and present an opportunity for junior investigators to interact with senior investigators in the field. The significance of this proposal is that the Enzymes, Co-Enzymes and Metabolic Pathways GRC serves as the touchstone for the community of researchers investigating the molecular mechanisms of the biochemical reactions that are literally responsible for life. The health-relatedness of this application derives from the fact that a molecular description of disease processes is indispensable for the design of chemotherapy. PUBLIC HEALTH RELEVANCE: Vast networks of intricately regulated, enzymatically-catalyzed, biochemical pathways underlie all of biology. Discussions at this meeting cover a broad range of topics that are important for understanding the precise mechanisms by which enzyme catalysts enable and regulate these pathways. This understanding is critical to the development of new therapeutic interventions to treat human disease and infections.