2012/2013 Enzymes, Coenzymes, and Metabolic Pathways Gordon Research Conference

描述(由申请人提供)：本提案请求部分支持2012年和2013年戈登研究会议，会议主题为“酶、辅酶和代谢途径”，定于2012年7月15-20日和2013年7月在新罕布夏州沃特维尔山谷的沃特维尔山谷度假村举行。这次会议的广泛和长期目标是促进对生化途径及其相关催化剂的分子水平的理解。我们的具体目标是介绍一个有~36名演讲者(8人选自海报摘要)的计划，描述酶机制和调控、酶和代谢工程以及代谢和基因控制的基础机制方面的最新进展。下午的海报会议为所有与会者提供了介绍其工作的场所，并为初级调查员提供了与外地高级调查员互动的机会。这一建议的意义在于，酶、辅酶和代谢途径GRC是研究人员社区调查生化反应分子机制的试金石，这些生化反应实际上是导致生命的。这一应用的健康相关性源于这样一个事实，即疾病过程的分子描述对于化疗的设计是不可或缺的。 与公共健康相关：由错综复杂的调控、酶催化的生化途径组成的庞大网络构成了所有生物学的基础。这次会议的讨论涵盖了广泛的主题，这些主题对于理解酶催化剂启用和调节这些途径的确切机制非常重要。这一认识对于开发治疗人类疾病和感染的新的治疗干预措施至关重要。

DESCRIPTION (provided by applicant): This proposal requests partial support of the 2012 and 2013 Gordon Research Conferences on "Enzymes, Coenzymes, and Metabolic Pathways", which are scheduled for July 15 - 20, 2012 and in July, 2013 at Waterville Valley Resort, Waterville Valley, New Hampshire. The broad and long-term goal of this conference is to foster a molecular-level understanding of biochemical pathways and their associated catalysts. Our specific aim is to present a program of ~36 speakers (8 chosen from poster abstracts), describing recent advances in enzyme mechanisms and regulation, enzyme and metabolic engineering, and the mechanisms underlying metabolic and genetic control. Afternoon poster sessions provide a venue for all attendees to present their work and present an opportunity for junior investigators to interact with senior investigators in the field. The significance of this proposal is that the Enzymes, Co-Enzymes and Metabolic Pathways GRC serves as the touchstone for the community of researchers investigating the molecular mechanisms of the biochemical reactions that are literally responsible for life. The health-relatedness of this application derives from the fact that a molecular description of disease processes is indispensable for the design of chemotherapy. PUBLIC HEALTH RELEVANCE: Vast networks of intricately regulated, enzymatically-catalyzed, biochemical pathways underlie all of biology. Discussions at this meeting cover a broad range of topics that are important for understanding the precise mechanisms by which enzyme catalysts enable and regulate these pathways. This understanding is critical to the development of new therapeutic interventions to treat human disease and infections.