Sphingolipid mediators in atherogenesis

动脉粥样硬化形成中的鞘脂介质

• 批准号: 8307868
• 负责人: Timothy Tun Hla
• 金额: $ 51.58万
• 依托单位: UNIVERSITY OF CONNECTICUT SCH OF MED/DNT
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8307868
• 关键词: Accounting; Address; Anti-Inflammatory Agents; Anti-inflammatory; Apolipoprotein E; Area; Arterial Fatty Streak; Arteries; Atherosclerosis; Attenuated; Autocrine Communication; Biochemical; Blood Vessels; Bone Marrow; Bone Marrow Transplantation; Caspase; Cell membrane; Cells; Cholesterol; Cholesterol Homeostasis; Coagulation Process; Complex; Coupled; Data; Dendritic Cells; Development; Dominant-Negative Mutation; Etiology; Exhibits; GTP-Binding Proteins; Gene Expression; Genes; H218 Protein; Heart Diseases; Hematopoietic; Hematopoietic stem cells; High Density Lipoproteins; Human; Hypoxia; Immune system; Inflammation; Inflammatory; Inflammatory Response; Instruction; Interleukin-18; Knockout Mice; Knowledge; Laboratories; Lead; Lipoproteins; Mediating; Mediator of activation protein; Membrane Microdomains; Messenger RNA; Metabolism; Modeling; Molecular; Mus; Myelogenous; Myeloid Cells; Myocardial Infarction; New Agents; PTEN gene; Pathogenesis; Pathologic; Pathway interactions; Peptide Hydrolases; Phenotype; Phospholipids; Phosphoric Monoester Hydrolases; Plasma; Production; Receptor Signaling; Regulation; Role; Signal Transduction; Sphingolipids; Sphingomyelinase; Sphingomyelins; Sphingosine-1-Phosphate Receptor; Stem cells; Stimulus; System; Testing; Therapeutic; Translational Regulation; Vascular Diseases; Vascular Permeabilities; Vascular System; Work; atherogenesis; base; cytokine; essential phospholipids; expression vector; in vivo; lipid mediator; macrophage; mouse model; mutant; novel; novel strategies; receptor; receptor coupling; research study; response; retinal angiogenesis; rho; rho GTP-Binding Proteins; sphingosine 1-phosphate; sphingosine kinase; tool; trafficking; vascular inflammation