Efficacy of Massage Therapy for the Treatment of Generalized Anxiety Disorder

按摩疗法治疗广泛性焦虑症的疗效

• 批准号: 8403465
• 负责人: Mark Hyman Rapaport
• 金额: $ 20.11万
• 依托单位: EMORY UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-30 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8403465
• 关键词: Acute; Age of Onset; Alternative Medicine; American; Anxiety; Anxiety Disorders; Argipressin; Back Pain; Biological; Blood Circulation; Childbirth; Chronic; Clinical Trials; Complementary and alternative medicine; Controlled Study; Corticotropin; Data; Development; Disease; Fatigue; Feeling; General Practitioners; Generalized Anxiety Disorder; Goals; Headache; Health; Health Benefit; Housing; Hydrocortisone; Impairment; Individual; Industry; Intervention; Investigation; Light; Massage; Measures; Medical; Mental Depression; Musculoskeletal; Myalgia; Oxytocin; Pain; Patients; Personal Satisfaction; Physicians; Pilot Projects; Placebos; Policies; Population; Pregnancy; Prevalence; Primary Health Care; Quality of life; Randomized Controlled Clinical Trials; Relaxation; Reporting; Research; Salivary; Serum; Sleeplessness; Symptoms; Therapeutic; Time; Touch sensation; Visit; Well in self; Work; base; care seeking; cost; design; functional disability; gastrointestinal; improved; patient population; primary care setting; psychobiology; psychologic; public health relevance; respiratory; response; standardize measure; treatment effect

DESCRIPTION (provided by applicant): Massage therapy is one of the fastest-growing complementary and alternative medical therapies with a 36% increase in visits to massage therapists between 1990 and 1997 and an estimated annual cost of 4 to 6 billion dollars. Individuals seek-out massage therapy for an array of concerns including backaches, muscle aches, headaches, feelings of tension, anxiety, fatigue, and insomnia. Massage therapy is purported to improve circulation, decrease symptoms of anxiety, depression, and pain, as well as stimulate feelings of well being. Despite its widespread use, there has been little systematic investigation of the efficacy of massage in carefully characterized patient populations and very little is known about the interaction between pathological conditions and the mechanism of action of massage therapy. As acknowledged in the White House Commission on Complementary and Alternative Medicine Policy (2002), there is a need for research investigating the efficacy of massage therapy in traditional medical disorders as well as studies explaining the mechanism responsible for the beneficial effects of massage therapy. In response to PA-06-510, we propose investigating the efficacy of massage therapy in well-characterized patients with Generalized Anxiety Disorder (GAD), a prevalent and debilitating condition. Our working hypothesis is that massage therapy will cause a significant decrease in both objective and subjective symptoms of GAD when compared and contrasted with the light touch condition, which we have demonstrated is a placebo. The specific aims of this pilot project are to investigate: 1) the acute effects of 6 weeks of massage therapy on the symptoms of GAD; 2) whether 12 weeks of massage therapy is more effective than 5 weeks of massage therapy in decreasing symptoms of GAD; and 5) whether massage therapy increases levels of oxytocin, decreases AVP, and HPA function in subjects with GAD. The results of the study will facilitate the development of a larger acute clinical trial investigating the efficacy of massage therapy as an alternate treatment for treatment for GAD, as well as gather preliminary data about the psychobiology of a massage intervention for GAD. PUBLIC HEALTH RELEVANCE: Despite its purported health benefits and the widespread acceptance of massage therapy throughout the world, little is known about the impact of therapeutic massage on pathological conditions such as Generalized Anxiety Disorder. Research is needed to investigate the efficacy of massage therapy in the treatment of such medical conditions and to demonstrate that it is an acceptable alternative to more traditional medical and psychological therapies. The proposed study will examine the efficacy of massage therapy for the treatment of generalized anxiety. We will gather preliminary data necessary to design a larger, randomized, controlled clinical trial. The results will also provide valuable preliminary data about the effects of massage on biological parameters in subjects with GAD.

描述（由申请人提供）：按摩疗法是增长最快的补充和替代医学疗法之一，1990 年至 1997 年间，按摩治疗师的就诊次数增加了 36%，估计每年的费用为 4 至 60 亿美元。人们寻求按摩疗法来解决一系列问题，包括背痛、肌肉酸痛、头痛、紧张感、焦虑、疲劳和失眠。按摩疗法据称可以改善血液循环，减少焦虑、抑郁和疼痛症状，并激发幸福感。尽管其广泛使用，但对按摩在仔细表征的患者群体中的功效几乎没有进行系统的研究，并且对于病理状况与按摩治疗的作用机制之间的相互作用知之甚少。正如白宫补充和替代医学政策委员会（2002 年）所承认的那样，需要进行研究调查按摩疗法对传统医学疾病的功效以及解释按摩疗法有益作用的机制。针对 PA-06-510，我们建议调查按摩疗法对患有广泛性焦虑症 (GAD)（一种普遍且令人衰弱的疾病）的特征明确的患者的疗效。我们的工作假设是，与轻触条件相比，按摩疗法将导致广泛性焦虑症的客观和主观症状显着减轻，我们已经证明轻触条件是安慰剂。该试点项目的具体目的是调查：1）6周的按摩疗法对广泛性焦虑症症状的急性影响； 2）12周的按摩治疗是否比5周的按摩治疗更能有效减轻广泛性焦虑症的症状； 5) 按摩疗法是否会增加 GAD 受试者的催产素水平、降低 AVP 和 HPA 功能。该研究的结果将有助于开展更大规模的急性临床试验，调查按摩疗法作为广泛性焦虑症替代疗法的功效，并收集有关按摩干预广泛性焦虑症的心理生物学的初步数据。 公共健康相关性：尽管按摩疗法据称具有健康益处并且在全世界范围内被广泛接受，但人们对治疗性按摩对广泛性焦虑症等病理状况的影响知之甚少。需要进行研究来调查按摩疗法在治疗此类疾病中的功效，并证明它是更传统的医学和心理疗法的可接受的替代方案。拟议的研究将检验按摩疗法治疗广泛性焦虑的功效。我们将收集设计更大规模的随机对照临床试验所需的初步数据。研究结果还将提供有关按摩对广泛性焦虑症患者生物参数影响的有价值的初步数据。

项目成果

Acute Swedish Massage Monotherapy Successfully Remediates Symptoms of Generalized Anxiety Disorder: A Proof-of-Concept, Randomized Controlled Study.

急性瑞典式按摩单一疗法成功缓解广泛性焦虑症的症状：一项概念验证、随机对照研究。

• DOI: 10.4088/jcp.15m10151
• 发表时间: 2016
• 期刊: The Journal of clinical psychiatry
• 作者: Rapaport,MarkHyman;Schettler,Pamela;Larson,ErikaR;Edwards,SherryA;Dunlop,BoadieW;Rakofsky,JeffreyJ;Kinkead,Becky
• 通讯作者: Kinkead,Becky

Six versus twelve weeks of Swedish massage therapy for generalized anxiety disorder: Preliminary findings.

• DOI: 10.1016/j.ctim.2020.102593
• 发表时间: 2021-01
• 期刊: Complementary therapies in medicine
• 影响因子: 3.6
• 作者: Rapaport MH;Schettler PJ;Larson ER;Dunlop BW;Rakofsky JJ;Kinkead B
• 通讯作者: Kinkead B