Neuroimaging Cognitive Vulnerability in Hypertension

高血压的神经影像认知脆弱性

• 批准号: 8320873
• 负责人: Andreana Petrova Haley
• 金额: $ 33.26万
• 依托单位: UNIVERSITY OF TEXAS AT AUSTIN
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-01 至 2014-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8320873
• 关键词: Activities of Daily Living; Adult; Affect; Age; Aging; Area; Behavioral; Blood Glucose; Blood Pressure; Brain; Brain region; Caring; Cerebrum; Clinical; Cognition; Cognitive; Coupled; Data; Diabetes Mellitus; Disease; Dyslipidemias; Early identification; Early treatment; Economics; Elderly; Ensure; Exercise stress test; Exhibits; Financial compensation; Functional Magnetic Resonance Imaging; Functional disorder; Future; Glutamates; Goals; Health; Healthcare; Hyperglycemia; Hypertension; Impaired cognition; Individual; Inositol; Life; Life Expectancy; Lipoproteins; Magnetic Resonance Spectroscopy; Measures; Mediating; Medical; Metabolic syndrome; Metabolism; Modality; N-acetylaspartate; Neurobehavioral Manifestations; Neurons; Neurotransmitters; Obesity; Paper; Participant; Pattern; Performance; Peripheral; Persons; Phenotype; Physiological; Population; Prevalence; Prevention; Problem Solving; Process; Protons; Quality of life; Reaction Time; Risk; Short-Term Memory; Staging; Stress; Symptoms; Syndrome; System; Task Performances; Techniques; Testing; Time; Unmarried person; Work; base; brain metabolism; cardiovascular disorder risk; cerebrovascular; clinically significant; cognitive function; cost; design; efficacy testing; functional restoration; middle age; neurochemistry; neuroimaging; neuromechanism; pre-clinical; prevent; psychologic; relating to nervous system; response; social; success

DESCRIPTION (provided by applicant): Cognition is the most important determinant of functional ability and quality of life. Diminished cognitive capacity can cause significant psychological, social, and economic hardship and adversely impact a person's ability to benefit from treatment for other medical problems. The most rapidly rising threat to cognitive health in US adults is the clustering of obesity, hypertension, hyperglycemia and dyslipidemia in a single person, a condition known as metabolic syndrome (MetS). A staggering 34-45% of US adults currently fulfill criteria for MetS. While we have some information about each of the disrupted peripheral physiological mechanisms in turn, very little is known about the central mechanisms that connect the syndrome to brain health and cognition. The goal of the proposed work is to explore the underlying neural mechanisms of MetS-related brain vulnerability in midlife, before clinically significant and permanent cognitive dysfunction has developed. Understanding the pre-clinical stages of disease has the enormous advantage of presenting opportunities for early intervention, a task with much higher prospect of success than striving to restore lost function later in life. The specific aims of this project will be accomplished by examining behavioral performance, cerebral metabolism, and brain response to a cognitive challenge in cognitively intact middle-aged adults with and without MetS in a cross sectional between groups design. We propose to first define the unique patterns of cerebrovascular response to cognition associated with MetS using functional magnetic resonance imaging (fMRI); then, to characterize the changes in neuronal viability associated with midlife MetS using neurospectroscopy (1H MRS); and finally, to test if neurochemical alterations mediate the observed alterations in functional brain activation in response to a cognitive challenge using path analysis.

描述（由申请人提供）：认知是功能能力和生活质量的最重要决定因素。认知能力下降会导致严重的心理，社会和经济困难，并对一个人从其他医疗问题的治疗中获益的能力产生不利影响。对美国成年人认知健康的最迅速上升的威胁是肥胖、高血压、高血糖和血脂异常在一个人身上的聚集，这种情况被称为代谢综合征（MetS）。目前，34-45%的美国成年人符合MetS的标准。虽然我们有一些关于每个被破坏的外围生理机制的信息，但对将综合征与大脑健康和认知联系起来的中枢机制知之甚少。这项工作的目标是在临床上显着和永久性认知功能障碍出现之前，探索中年MetS相关脑脆弱性的潜在神经机制。了解疾病的临床前阶段具有为早期干预提供机会的巨大优势，这是一项比在以后的生活中努力恢复失去的功能具有更高成功前景的任务。该项目的具体目标将通过检查行为表现，大脑代谢和大脑对认知完整的中年人的认知挑战的反应来完成，有和没有MetS组间设计的横截面。我们建议首先使用功能性磁共振成像（fMRI）定义脑血管对与代谢综合征相关的认知反应的独特模式;然后，使用神经光谱学（1H MRS）表征与中年代谢综合征相关的神经元活力变化;最后，测试神经化学变化是否介导了所观察到的脑功能激活变化，以应对认知挑战，使用路径分析。