Steroid Hormone Signaling in Genetically Obese Drosophila

遗传性肥胖果蝇中的类固醇激素信号传导

• 批准号: 8232912
• 负责人: ANDREW J ANDRES
• 金额: $ 28.59万
• 依托单位: UNIVERSITY OF NEVADA LAS VEGAS
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-05-01 至 2016-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8232912
• 关键词: Adipose tissue; Adult; Affect; Alleles; Animal Feed; Animals; Area; Bioinformatics; Biological Metamorphosis; Biological Models; Body fat; Candidate Disease Gene; Cells; Communities; Country; Data; Development; Developmental Delay Disorders; Diabetes Mellitus; Diet; Doctor of Philosophy; Drosophila genus; Drosophila melanogaster; Ecdysterone; Educational process of instructing; Energy-Generating Resources; Enrollment; Environment; Epidemic; Exercise; Fat Body; Fatty acid glycerol esters; Gene Targeting; Generations; Genes; Genetic; Genetic Predisposition to Disease; Genomics; Gland; Glues; Goals; Grant; Health; Hormonal; Hormones; Human; Individual; Institution; Larva; Learning; Length; Link; Lipids; Malignant Neoplasms; Medical; Methods; Modeling; Morbidity - disease rate; Nutrient; Obesity; Organ; Pathology; Pathway interactions; Phenotype; Physiologic pulse; Physiological; Population; Prevalence; RNA Interference; Recruitment Activity; Reproduction; Research; Research Project Grants; Resistance; Role; Salivary Glands; Signal Pathway; Signal Transduction; Staging; Starvation; Steroids; Students; System; Testing; Time; Tissues; United States; Vertebrates; Work; base; cardiovascular disorder risk; cell growth; direct application; fly; gene function; genetic risk factor; human disease; improved; mortality; overexpression; response; sensor; steroid hormone; tool

DESCRIPTION (provided by applicant): Genetically obese Drosophila has been developed by selecting for starvation resistance. This project will investigate hormonal mechanisms that cause Drosophila to accumulate excess lipids. Genomic methods will be used to identify the genetic basis for lipid storage. PUBLIC HEALTH RELEVANCE: This study uses genetically obese fruit flies as a model to understand genetic factors contributing to human obesity. The goal is to identify genes and hormonal pathways that cause cells and animals to accumulate fat.

描述（由申请人提供）：遗传性肥胖果蝇是通过选择抗饥饿性而培育出来的。该项目将研究导致果蝇积累过量脂质的激素机制。基因组方法将用于确定脂质储存的遗传基础。 公共健康相关性：这项研究使用遗传性肥胖果蝇作为模型来了解导致人类肥胖的遗传因素。目标是确定导致细胞和动物积累脂肪的基因和激素途径。

项目成果

Starvation selection reduces and delays larval ecdysone production and signaling.

• DOI: 10.1242/jeb.246144
• 发表时间: 2023-09-15
• 期刊: The Journal of experimental biology