遗传性肥胖果蝇中的类固醇激素信号传导-猫眼课题宝

遗传性肥胖果蝇中的类固醇激素信号传导

批准号：

8232912

负责人：

ANDREW J ANDRES

金额：

$28.59万

依托单位：

UNIVERSITY OF NEVADA LAS VEGAS

依托单位国家：

美国

项目类别：

财政年份：

2012

资助国家：

美国

项目状态：

已结题

起止时间：

2012-05-01 至 2016-04-30

来源：

https://reporter.nih.gov/project-details/8232912

关键词：

Adipose tissue Adult Affect Alleles Animal Feed Animals Area Bioinformatics Biological Metamorphosis Biological Models Body fat Candidate Disease Gene Cells Communities Country Data Development Developmental Delay Disorders Diabetes Mellitus Diet Doctor of Philosophy Drosophila genus Drosophila melanogaster Ecdysterone Educational process of instructing Energy-Generating Resources Enrollment Environment Epidemic Exercise Fat Body Fatty acid glycerol esters Gene Targeting Generations Genes Genetic Genetic Predisposition to Disease Genomics Gland Glues Goals Grant Health Hormonal Hormones Human Individual Institution Larva Learning Length Link Lipids Malignant Neoplasms Medical Methods Modeling Morbidity - disease rate Nutrient Obesity Organ Pathology Pathway interactions Phenotype Physiologic pulse Physiological Population Prevalence RNA Interference Recruitment Activity Reproduction Research Research Project Grants Resistance Role Salivary Glands Signal Pathway Signal Transduction Staging Starvation Steroids Students System Testing Time Tissues United States Vertebrates Work base cardiovascular disorder risk cell growth direct application fly gene function genetic risk factor human disease improved mortality overexpression response sensor steroid hormone tool

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英文摘要

DESCRIPTION (provided by applicant): Genetically obese Drosophila has been developed by selecting for starvation resistance. This project will investigate hormonal mechanisms that cause Drosophila to accumulate excess lipids. Genomic methods will be used to identify the genetic basis for lipid storage. PUBLIC HEALTH RELEVANCE: This study uses genetically obese fruit flies as a model to understand genetic factors contributing to human obesity. The goal is to identify genes and hormonal pathways that cause cells and animals to accumulate fat.

期刊论文(1)

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会议论文

Starvation selection reduces and delays larval ecdysone production and signaling.

DOI： 10.1242/jeb.246144

发表时间： 2023-09-15

期刊：

The Journal of experimental biology

影响因子： --

作者：

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