Dietary Patterns / Dietary Quality and Risk of RA in Women

女性饮食模式/饮食质量和 RA 风险

• 批准号: 8244617
• 负责人: Bing Lu
• 金额: $ 42.31万
• 依托单位: BRIGHAM AND WOMEN'S HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-08-17 至 2015-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8244617
• 关键词: Accounting; Address; Adult; Affect; All-Trans-Retinol; Alleles; Antioxidants; Arthritis; Autoimmune Diseases; Biochemical; Carotene; Cereals; Chronic; Cluster Analysis; Coffee; Cohort Studies; Consumption; Data; Development; Diet; Dietary Practices; Disease; Eating; Environment; Environmental Epidemiology; Environmental Risk Factor; Epidemiologic Studies; Etiology; Exogenous Hormone Therapy; Factor Analysis; Fatty acid glycerol esters; Female; Fishes; Food; Frequencies; Genes; Genetic; Goals; Individual; Intake; Interleukin-6; Investigation; Lutein; Measurement; Meat; Mediterranean Diet; Modification; Nurses; Nurses' Health Study; Nutrient; Olive oil preparation; Pathway interactions; Plasma; Population; Predisposition; Prevalence; Prevention; Prospective Studies; Public Health; Publishing; Questionnaires; Recommendation; Reproductive History; Rheumatism; Rheumatoid Arthritis; Rheumatoid Factor; Risk; Risk Factors; Sample Size; Serological; Statistical Models; TNFR-Fc fusion protein; Time; Tocopherols; United States; Vegetables; Vitamin D; Woman; base; case control; cigarette smoking; cohort; cooking; cost; cryptoxanthin; cyclic citrullinated peptide; design; disorder risk; epidemiology study; follow-up; food consumption; genetic epidemiology; genetic risk factor; good diet; indexing; inflammatory marker; lycopene; men; novel; novel strategies; nutritional epidemiology; prospective; protective effect; zeaxanthin

DESCRIPTION (provided by applicant): The etiology of rheumatoid arthritis (RA), remains incompletely understood. It is considered to be a multifactorial disease, resulting from the interaction of both genetic and environmental factors. Epidemiologic research has produced convincing data for associations between environmental risk factors, including cigarette smoking, exogenous hormone use and female reproductive factors and RA susceptibility. Dietary studies suggest that high intake of certain antioxidants, fish, olive oil and cooked vegetables confer a protective effect against the development of RA, whereas red meat, fat, dairy and cereals may increase the risk of RA, although evidence for dietary etiology is inconclusive. However, the effect of individual food groups and nutrients may be too small to detect with limited sample sizes in previous studies. Overall dietary pattern and dietary quality analysis examines the cumulative effects of multiple nutrients, and may thus be more predictive of disease risk than individual foods or nutrients. To date, no studies have assessed the association between overall dietary patterns / dietary quality and RA risk, especially in the setting of a well-controlled large prospective cohort study. The goal of the proposed investigation is to address whether overall dietary patterns / dietary quality are associated with risk of RA in women using data from the largest rheumatic disease environmental epidemiology study in the world, the two Nurses' Health Study Cohorts (NHS I and NHS II). We will also examine the causal pathways between dietary patterns / dietary quality, biochemical measurements including plasma antioxidants and markers of inflammation, and risk of developing RA in a matched case-control subsample nested in NHS I and II cohorts. In addition, we will investigate possible interactions between dietary patterns / dietary quality and genetic factors in RA susceptibility. With recent advances in genetic epidemiology and high throughput genotying, the study of gene-diet interactions has become an exciting direction in the field of nutritional epidemiology. Overall, the large size of these cohorts, the prospective design, the repeated and detailed measurements of diet and covariates, the high follow-up rates, and the availability of biochemical measurements provide a unique opportunity to study the relationship between overall dietary patterns /dietary quality and risk of RA in an extremely cost-efficient manner. We believe that this project presents a novel approach to study diet-RA relationships and will have important public health implications. PUBLIC HEALTH RELEVANCE: The evidence for dietary etiology of RA is inconclusive. To date, no studies have assessed the association between overall dietary patterns / dietary quality, gene by dietary pattern interaction, and risk of RA. Findings from this large cohort study will furnish novel information about diet and etiology of RA, and have large potential public health implications for RA prevention.

描述(由申请人提供)：类风湿性关节炎(RA)的病因仍不完全清楚。它被认为是一种多因素疾病，是遗传和环境因素共同作用的结果。流行病学研究已经提供了令人信服的数据，证明了环境风险因素之间的联系，包括吸烟、外源性激素使用和女性生殖因素与类风湿关节炎易感性之间的关系。饮食研究表明，大量摄入某些抗氧化剂、鱼、橄榄油和煮熟的蔬菜可以预防类风湿性关节炎的发展，而红肉、脂肪、乳制品和谷类食品可能会增加类风湿性关节炎的风险，尽管饮食病因的证据尚不确定。然而，在以前的研究中，由于样本量有限，个别食物组和营养素的影响可能太小而无法检测到。总体饮食模式和饮食质量分析检查多种营养素的累积影响，因此可能比单独的食物或营养素更能预测疾病风险。到目前为止，还没有研究评估总体饮食模式/饮食质量与类风湿性关节炎风险之间的联系，特别是在控制良好的大型前瞻性队列研究的背景下。这项拟议调查的目的是利用世界上最大的风湿病环境流行病学研究、两个护士健康研究队列(NHS I和NHS II)的数据，解决总体饮食模式/饮食质量是否与女性RA风险有关。我们还将研究饮食模式/饮食质量、包括血浆抗氧化剂和炎症标志物在内的生化测量与NHS I和II队列中嵌套的匹配病例对照亚样本中发生RA的风险之间的因果关系。此外，我们还将研究饮食结构/饮食质量与遗传因素在类风湿关节炎易感性中的可能相互作用。随着遗传流行病学和高通量基因定位的最新进展，基因-饮食相互作用的研究已成为营养流行病学领域的一个令人兴奋的方向。总体而言，这些队列的庞大规模、前瞻性设计、对饮食和协变量的重复和详细的测量、高随访率以及生化测量的可用性为以极具成本效益的方式研究总体饮食模式/饮食质量与类风湿关节炎风险之间的关系提供了独特的机会。我们相信，该项目为研究饮食与RA的关系提供了一种新的方法，并将对公共卫生产生重要影响。 公共卫生相关性：关于类风湿性关节炎饮食病因的证据尚无定论。到目前为止，还没有研究评估总体饮食模式/饮食质量、基因与饮食模式交互作用与类风湿关节炎风险之间的关系。这项大型队列研究的发现将为RA的饮食和病因学提供新的信息，并对RA的预防具有巨大的潜在公共卫生意义。