Genetics and Genomics of Muscle Postdoctoral Training Program

描述（由申请人提供）：为肌肉遗传学和基因组学博士后提供新的培训资助（T32）。培训师资来自国家儿童医学中心和马里兰大学。研究和训练主题包括肌肉萎缩症，运动生理学，肌肉再生，临床前和临床试验。技术培训是针对肌肉的基因组研究，如全基因组SNP关联研究（GWAS）、mRNA分析、蛋白质组学分析和系统生物学。生物信息学和统计学的培训以及适当的研究行为大大加强了这种技术台架培训。提出的T32在肌肉健康和疾病的转化训练中是独一无二的，有广泛的临床前和临床试验。综合生物学和系统生物学是导师的强项，为研究员提供广泛的生物信息学、统计学和人类/计算机可视化培训。拟议的培训计划既包括跨学科方法的教学培训，也包括动手实验和计算培训。拟议的培训师资队伍由研究者发起的个人研究资助和奖励的强大组合支持。拟议的培训计划的一个独特优势是联邦资助的肌肉转化研究中心和核心基金的基础，这将为拟议的T32研究员提供丰富的核心设施和试点资金机会。其中包括国家医学康复研究中心、儿科药理学研究单位、Wellstone肌肉萎缩症中心、国际神经肌肉合作研究小组临床试验网络、国防部肌肉萎缩症转化研究项目以及智力和发育障碍中心。

DESCRIPTION (provided by applicant): A new training grant (T32) for post-doctoral fellows in Genetics and Genomics of Muscle is described. Training faculty are drawn from Children's National Medical Center and University of Maryland. Research and training topics include muscular dystrophy, exercise physiology, muscle regeneration, and pre-clinical and clinical trials. Technological training Is in genome-enabled studies of muscle, such as genome-wide SNP association studies (GWAS), mRNA profiling, proteomic profiling, and systems biology. This technological bench training is heavily augmented with training in bioinformatics and statistics, and appropriate conduct of research. The proposed T32 is unique in the translational training for muscle in health and disease, with extensive pre-clinical and clinical trials. Integrative and systems biology are strengths of the preceptors, with extensive bioinformatics, statistics, and human/computer visualization training available to fellows. The proposed training program includes both didactic training in interdisciplinary approaches, as well as hands-on laboratory and computational training. The proposed training faculty are supported by a strong portfolio of investigator-initiated individual research grants and awards. A unique advantage of the proposed training program is the foundation of federally-funded Center and Core grants on muscle translational research that would provide rich core facilities and pilot funding opportunities for the proposed T32 fellows. These include a National Center for Medical Rehabilitation Research, Pediatric Pharmacology Research Unit, Wellstone Muscular Dystrophy Center, Cooperative International Neuromuscular Research Group clinical trial network, Department of Defense Program Project in Translational Research in the Muscular Dystrophies, and an Intellectual and Developmental Disabilities Center.