Genetics and Genomics of Muscle Postdoctoral Training Program

描述（由申请人提供）：一个新的培训补助金（T32）在遗传学和肌肉基因组学博士后研究员进行了说明。培训教师来自儿童国家医学中心和马里兰州大学。研究和培训主题包括肌肉萎缩症，运动生理学，肌肉再生，临床前和临床试验。技术培训是在基因组使能的肌肉研究，如全基因组SNP关联研究（GWAS），mRNA分析，蛋白质组分析和系统生物学。这种技术人员培训在很大程度上增加了生物信息学和统计学方面的培训，以及适当的研究工作。拟议的T32在健康和疾病中的肌肉平移训练方面是独一无二的，具有广泛的临床前和临床试验。综合和系统生物学是导师的优势，为研究员提供广泛的生物信息学，统计学和人类/计算机可视化培训。拟议的培训计划包括跨学科方法的教学培训，以及动手实验室和计算培训。拟议的培训学院得到了一个强大的投资组合的支持，该投资组合由财政部发起的个人研究赠款和奖项。拟议的培训计划的一个独特优势是联邦资助的中心和核心赠款的基础上肌肉转化研究，将提供丰富的核心设施和试点资助机会，为拟议的T32研究员。其中包括国家医疗康复研究中心、儿科药理学研究单位、Wellstone肌营养不良中心、国际神经肌肉研究合作组临床试验网络、国防部肌营养不良转化研究计划项目以及智力和发育障碍中心。

DESCRIPTION (provided by applicant): A new training grant (T32) for post-doctoral fellows in Genetics and Genomics of Muscle is described. Training faculty are drawn from Children's National Medical Center and University of Maryland. Research and training topics include muscular dystrophy, exercise physiology, muscle regeneration, and pre-clinical and clinical trials. Technological training Is in genome-enabled studies of muscle, such as genome-wide SNP association studies (GWAS), mRNA profiling, proteomic profiling, and systems biology. This technological bench training is heavily augmented with training in bioinformatics and statistics, and appropriate conduct of research. The proposed T32 is unique in the translational training for muscle in health and disease, with extensive pre-clinical and clinical trials. Integrative and systems biology are strengths of the preceptors, with extensive bioinformatics, statistics, and human/computer visualization training available to fellows. The proposed training program includes both didactic training in interdisciplinary approaches, as well as hands-on laboratory and computational training. The proposed training faculty are supported by a strong portfolio of investigator-initiated individual research grants and awards. A unique advantage of the proposed training program is the foundation of federally-funded Center and Core grants on muscle translational research that would provide rich core facilities and pilot funding opportunities for the proposed T32 fellows. These include a National Center for Medical Rehabilitation Research, Pediatric Pharmacology Research Unit, Wellstone Muscular Dystrophy Center, Cooperative International Neuromuscular Research Group clinical trial network, Department of Defense Program Project in Translational Research in the Muscular Dystrophies, and an Intellectual and Developmental Disabilities Center.