Genetics and Genomics of Muscle Postdoctoral Training Program

 描述（由申请人提供）：更新的培训补助金（T32）在遗传学和肌肉基因组学博士后研究员进行了说明。培训教师来自儿童国家医学中心，NIH内部计划和乔治华盛顿大学。研究和培训主题侧重于了解健康和疾病（营养不良和损伤）中的肌肉组织，重点是基因组启用方法和转化研究。基于实验室的技术培训包括最先进的研究方法，如基因组学，蛋白质组学，表观基因组学，生物标志物发现和验证，药物开发和临床前疗效和毒性。这种技术人员培训在很大程度上增加了生物信息学和统计学方面的培训，以及适当的研究工作。学员的独特机会包括在NIH NINDS和CNMC（2/9以前获奖者），ABMG认证（1/9），以及在CINRG组和NIH内部计划（2/9）的临床试验和结果测量培训中融入神经肌肉临床培训。公私伙伴关系、产业附带利益、知识产权发展方面的培训， 监管科学也是T32的主要优势。T32计划通过联邦资助的中心和核心赠款的强大基础的协同作用得到支持，这些赠款由培训学院领导，为T32研究员提供丰富的核心设施和试点资助机会。其中包括翻译研究中心（NIAMS P50），国家医疗康复研究中心（NICHD/NINDS R24），儿科发育药理学研究（NICHD U 54），CINRG临床试验网络（NIAMS RO 1和DoD赠款），小鼠病理学（NIH OD R26），智力和发育障碍研究中心（NICHD P30）和以儿科为重点的CTSA（NCATS）。最初的奖项通过高度竞争的过程填补了所有可用的职位，研究员发表了高影响力的论文，所有毕业生都保留在独立的学术生物医学研究职位上，包括领导肌肉萎缩症项目的捐赠主席，以及分子诊断实验室的负责人。约30%的受训人员是医生/科学家-这是最初培训方案的既定目标。我们将培养2名博士后 M.D.培训生和4名博士后。2001年培训生; 2名博士后培训生和5名博士后。2002年至2005年的受训人员。共有14名博士后学员将被任命为这个T-32计划在5年的资助周期。完成后，T32博士后研究员将能够独立完成研究项目，在多学科研究项目中合作，发表研究成果，申请独立资助，并在学术，制药和生物医学研究机构成功面试。

 DESCRIPTION (provided by applicant): A renewal for a training grant (T32) for post-doctoral fellows in Genetics and Genomics of Muscle is described. Training faculty is drawn from Children's National Medical Center, NIH intramural program, and George Washington University. Research and training topics focus on understanding muscle tissue in health and disease (dystrophy and damage), with an emphasis on genome-enabled approaches and translational research. Lab bench-based technological training includes state-of-art research methods such as genomics, proteomics, epigenomics, biomarker discovery and validation, drug development and pre-clinical efficacy and toxicity. This technological bench training is heavily augmented with training in bioinformatics and statistics, and appropriate conduct of research. Unique opportunities for trainees include integration into neuromuscular clinical training at both NIH NINDS and CNMC (2/9 previous awardees), ABMG certification (1/9), and training in clinical trials and outcome measures in the CINRG group and NIH intramural program (2/9). Training in private-public partnerships, industry spin-offs, intellectual property development, and regulatory science are also key strengths of the T32. The T32 program is bolstered through synergism by a strong foundation of federally-funded Center and Core grants on muscle translational research led by Training Faculty that provide rich core facilities and pilot funding opportunities for the T32 fellows. These include a Center of Research Translation (NIAMS P50), National Center for Medical Rehabilitation Research (NICHD/NINDS R24), Research in Pediatric Developmental Pharmacology (NICHD U54), CINRG clinical trial network (NIAMS RO1s and DoD grants on outcome measures), Mouse Pathobiology (NIH OD R26), Intellectual and Developmental Disabilities Research Center (NICHD P30), and pediatrics-focused CTSA (NCATS). The initial award filled all available slots through a highly competitive process, with fellows publishing high impact papers, and all graduates retained in independent academic biomedical research positions, including an endowed chair leading a muscular dystrophy program, and head of a molecular diagnostics laboratory. ~30% of trainees were physician/scientists - a stated goal of the original training program. We will train 2 postdoctoral M.D. trainee and 4 postdoctoral Ph.D. trainees in Yr01; 2 postdoctoral M.D. trainees and 5 postdoctoral Ph.D. trainees in Yrs02 through Yr05. A total of 14 postdoctoral trainees will be appointed to this T-32 program over the 5 year funding cycle. At completion, the T32 postdoctoral fellows will be able to independently complete research projects, collaborate in multi-disciplinary research projects, publish research results, apply for independent funding, and successfully interview in academic, pharmaceutical and biomedical research institutions.