Genetics and Genomics of Muscle Postdoctoral Training Program

肌肉遗传学与基因组学博士后培养项目

• 批准号: 9272835
• 负责人: JYOTI K JAISWAL
• 金额: $ 25.24万
• 依托单位: CHILDREN'S RESEARCH INSTITUTE
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-05-28 至 2020-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/9272835
• 关键词: Genetic; Genomics; Muscle; Training Programs; post-doctoral training

 DESCRIPTION (provided by applicant): A renewal for a training grant (T32) for post-doctoral fellows in Genetics and Genomics of Muscle is described. Training faculty is drawn from Children's National Medical Center, NIH intramural program, and George Washington University. Research and training topics focus on understanding muscle tissue in health and disease (dystrophy and damage), with an emphasis on genome-enabled approaches and translational research. Lab bench-based technological training includes state-of-art research methods such as genomics, proteomics, epigenomics, biomarker discovery and validation, drug development and pre-clinical efficacy and toxicity. This technological bench training is heavily augmented with training in bioinformatics and statistics, and appropriate conduct of research. Unique opportunities for trainees include integration into neuromuscular clinical training at both NIH NINDS and CNMC (2/9 previous awardees), ABMG certification (1/9), and training in clinical trials and outcome measures in the CINRG group and NIH intramural program (2/9). Training in private-public partnerships, industry spin-offs, intellectual property development, and regulatory science are also key strengths of the T32. The T32 program is bolstered through synergism by a strong foundation of federally-funded Center and Core grants on muscle translational research led by Training Faculty that provide rich core facilities and pilot funding opportunities for the T32 fellows. These include a Center of Research Translation (NIAMS P50), National Center for Medical Rehabilitation Research (NICHD/NINDS R24), Research in Pediatric Developmental Pharmacology (NICHD U54), CINRG clinical trial network (NIAMS RO1s and DoD grants on outcome measures), Mouse Pathobiology (NIH OD R26), Intellectual and Developmental Disabilities Research Center (NICHD P30), and pediatrics-focused CTSA (NCATS). The initial award filled all available slots through a highly competitive process, with fellows publishing high impact papers, and all graduates retained in independent academic biomedical research positions, including an endowed chair leading a muscular dystrophy program, and head of a molecular diagnostics laboratory. ~30% of trainees were physician/scientists - a stated goal of the original training program. We will train 2 postdoctoral M.D. trainee and 4 postdoctoral Ph.D. trainees in Yr01; 2 postdoctoral M.D. trainees and 5 postdoctoral Ph.D. trainees in Yrs02 through Yr05. A total of 14 postdoctoral trainees will be appointed to this T-32 program over the 5 year funding cycle. At completion, the T32 postdoctoral fellows will be able to independently complete research projects, collaborate in multi-disciplinary research projects, publish research results, apply for independent funding, and successfully interview in academic, pharmaceutical and biomedical research institutions.

 描述(由申请人提供)：描述了为肌肉遗传学和基因组学博士后研究员提供的培训补助金(T32)的续签。培训人员来自国家儿童医学中心、美国国立卫生研究院校内项目和乔治华盛顿大学。研究和培训主题侧重于了解肌肉组织在健康和疾病(营养不良和损伤)中的作用，重点是基因组启用的方法和转译研究。以实验室为基础的技术培训包括最先进的研究方法，如基因组学、蛋白质组学、表观基因组学、生物标记物的发现和验证、药物开发以及临床前的疗效和毒性。在生物信息学和统计学方面的培训，以及适当的研究工作，大大加强了这种技术培训。对于学员来说，独特的机会包括融入NIH NINDS和CNMC的神经肌肉临床培训(2/9以前的获奖者)，ABMG认证(1/9)，以及CINRG小组和NIH内部计划的临床试验和结果评估培训(2/9)。培训公私伙伴关系、行业衍生产品、知识产权开发以及 监管科学也是T32的关键优势。T32计划通过协同效应得到支持，联邦政府资助的肌肉翻译研究中心和核心拨款的强大基础由培训学院领导，为T32研究员提供丰富的核心设施和试点资助机会。这些机构包括研究翻译中心(NIAMS P50)、国家医疗康复研究中心(NICHD/NINDS R24)、儿科发展药理学研究(NICHD U54)、CINRG临床试验网络(NIAMS RO1和美国国防部关于结果衡量的拨款)、小鼠病理生物学(NIH OD R26)、智力和发育障碍研究中心(NICHD P30)以及以儿科为中心的CTSA(NCATS)。最初的奖项通过一个竞争激烈的过程填补了所有空缺，研究员发表了高影响力的论文，所有毕业生都留在了独立的学术生物医学研究职位上，包括一名领导肌肉营养不良症计划的捐赠主席和一家分子诊断实验室的负责人。约30%的受训人员是医生/科学家--这是最初培训计划的既定目标。我们将培养2名博士后 01年度2名博士后实习生和4名博士后实习生；02至05年度2名博士后实习生和5名博士后实习生。在5年的资助周期内，共有14名博士后实习生将被任命参加这个T-32项目。完成后，T32博士后研究员将能够独立完成研究项目，合作多学科研究项目，发布研究成果，申请独立资助，并成功面试学术、制药和生物医学研究机构。