Neuroimaging of Trauma Memory and Cognitive Reappraisal in PTSD

创伤后应激障碍（PTSD）创伤记忆和认知重评的神经影像学

• 批准号: 8043287
• 负责人: Jasmeet Pannu Hayes
• 金额: $ 14.02万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8043287
• 关键词: Accounting; Adult; Affect; Afghanistan; Amygdaloid structure; Arousal; Attention; Award; Basic Science; Behavior Therapy; Belief System; Biological Neural Networks; Brain; Brain imaging; Brain region; Climate; Clinical; Cognitive; Cognitive Therapy; Cognitive deficits; Cues; Development; Diagnosis; Disease; Doctor of Philosophy; Emotional; Emotional Stress; Emotions; Event; Exposure to; Family; Feeling hopeless; Friends; Fright; Functional Magnetic Resonance Imaging; Functional disorder; Goals; Hippocampus (Brain); Image Analysis; Intervention; Iraq; Lead; Life; Link; Maintenance; Medial; Medical center; Memory; Memory Loss; Mentored Patient-Oriented Research Career Development Award; Mentors; Modeling; Patient Education; Patients; Performance; Post-Traumatic Stress Disorders; Postdoctoral Fellow; Prefrontal Cortex; Principal Investigator; Process; Randomized Clinical Trials; Recurrence; Regulation; Research; Research Personnel; Role; Scientist; Social Values; Soldier; Stress; Symptoms; System; Temporal Lobe; Time; Training; Trauma; United States Public Health Service; Universities; Veterans; War; Work; base; career; career development; cognitive change; cognitive control; cognitive function; cognitive neuroscience; combat; conditioned fear; effective therapy; emotion regulation; emotional distress; emotional experience; experience; imaging modality; insight; memory encoding; neural circuit; neuroimaging; neuromechanism; novel; professor; programs; psychosocial; public health relevance; relating to nervous system; skills; social

DESCRIPTION (provided by applicant): The principal investigator on this K23 Mentored Patient-Oriented Research Career Development Award is Jasmeet Pannu Hayes, Ph.D., a Research Associate at the Duke University Brain Imaging and Analysis Center and Durham VA Medical Center. Dr. Kevin LaBar, Associate Professor at Duke University, and Dr. Jean Beckham, VA Career Scientist, will serve as mentor and co-mentor on this award. The candidate's career development goals encompass two broad objectives that will lead to an independent research career. The first objective is to develop expertise in emotional memory research, with particular emphasis on memory alterations in posttraumatic stress disorder (PTSD). The second objective is to develop the technical skills necessary to apply advanced functional magnetic resonance imaging (fMRI) methods including functional and effective connectivity analyses to the study of emotional memory. Two fMRI studies are proposed with the goal of examining the neural networks involved in trauma memory encoding and emotion regulation of trauma memories in PTSD. In this proposal, brain activity in Iraq and Afghanistan War veterans diagnosed with PTSD will be compared with brain activation in veterans who have also been involved in traumatic combat events, but have not developed PTSD. PTSD occurs after exposure to a traumatic event, evoking emotions of intense fear, horror, and helplessness. Symptoms of the disorder include involuntary re-experiencing of the traumatic event, numbing and avoidance of reminders of the traumatic event, and hyperarousal when exposed to internal or external cues of the traumatic event. Research of neural networks involved in the onset, maintenance, and amelioration of PTSD symptomatology will provide greater understanding of effective treatments. PTSD research is vital given the current war climate context, as greater numbers of soldiers are returning from Iraq and Afghanistan and are attempting to transition into civilian life, often with great difficulty. Thus, the ultimate goal of this K23 award is to examine the connectivity of trauma memory and emotion regulation strategies that hold great promise as behavioral interventions for PTSD. PUBLIC HEALTH RELEVANCE: Rates of PTSD in returning Iraq and Afghanistan War veterans are high, placing great demands on public health services. Furthermore, cognitive deficits that result from PTSD often lead to disturbances at work, as well as interpersonal difficulties with family, friends, and co-workers. Thus, insights gained from research on the neural basis of traumatic memories and their regulation has immense clinical and social value.

描述（由申请人提供）：K23指导的以患者为导向的研究职业发展奖的主要研究者是Jasmeet Pannu Hayes博士，杜克大学脑成像和分析中心和达勒姆退伍军人医疗中心的研究助理。杜克大学副教授Kevin LaBar博士和弗吉尼亚州职业科学家Jean Beckham博士将担任该奖项的导师和共同导师。候选人的职业发展目标包括两个广泛的目标，这将导致一个独立的研究生涯。第一个目标是发展情感记忆研究的专业知识，特别强调创伤后应激障碍（PTSD）的记忆改变。第二个目标是发展必要的技术技能，应用先进的功能性磁共振成像（fMRI）方法，包括功能和有效的连接分析，以研究情绪记忆。两个功能磁共振成像研究的目的是检查创伤记忆编码和创伤记忆的情绪调节PTSD的神经网络。在这项提案中，被诊断患有创伤后应激障碍的伊拉克和阿富汗战争退伍军人的大脑活动将与也参与创伤性战斗事件但没有发展为创伤后应激障碍的退伍军人的大脑活动进行比较。创伤后应激障碍发生在暴露于创伤事件后，唤起强烈的恐惧，恐怖和无助的情绪。该障碍的症状包括创伤性事件的无意识重新体验、麻木和回避创伤性事件的提醒、以及当暴露于创伤性事件的内部或外部线索时的过度觉醒。研究神经网络参与PTSD的发病、维持和改善，将为有效的治疗提供更好的理解。在当前的战争环境下，创伤后应激障碍研究至关重要，因为越来越多的士兵从伊拉克和阿富汗返回，并试图过渡到平民生活，往往困难重重。因此，这个K23奖的最终目标是研究创伤记忆和情绪调节策略之间的联系，这些策略作为PTSD的行为干预措施具有很大的前景。公共卫生相关性：返回伊拉克和阿富汗战争退伍军人的创伤后应激障碍发生率很高，对公共卫生服务提出了很高的要求。此外，PTSD导致的认知缺陷通常会导致工作中的干扰，以及与家人，朋友和同事的人际交往困难。因此，从创伤记忆的神经基础及其调节的研究中获得的见解具有巨大的临床和社会价值。