Molecular Mechanisms of SKP2 Targeting on Prostate Cancer Progression

SKP2靶向前列腺癌进展的分子机制

• 批准号: 8340131
• 负责人: LYNN M MATRISIAN
• 金额: $ 7.39万
• 依托单位: VANDERBILT UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-23 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8340131
• 关键词: African American; American; Androgens; Cancer Control; Cancer Patient; Castration; Caucasians; Caucasoid Race; Death Rate; Disease; Ethnic group; Growth; Incidence; Investigation; Malignant Neoplasms; Malignant neoplasm of prostate; Molecular; Operative Surgical Procedures; Pathway interactions; Race; Radiation therapy; Regulation; Resistance; Role; SKP2 gene; Signal Pathway; The Vanderbilt-Ingram Cancer Center at the Vanderbilt University; cancer diagnosis; cancer health disparity; cancer statistics; deprivation; male; men; mortality; tumor progression

Prostate cancer (PCa) is a prevailing disease found in African American men, and is the most frequently diagnosed cancer in American men. African American males died of PCa in a 2.39-folder higher rate as compared with Caucasian males, while the average death rate due to all cancers was only 1.34-fold higher between these two races (Cancer Statistics 2010)^¿. Surgery, radiation therapy and androgen-deprivation therapy have been developed and applied widely to control PCa; however, prostate cancer patients still died of Castration Resistant Prostate Cancer (CRPC). Molecular signaling pathways contributing to the initiation and progression of PCa; particularly, the mechanism of CRPC growth remain to be elucidated in order to develop efficient strategies for cancer control. Aberrant regulation of Pten-PI3K-Akt pathway, p53 loss and Skp2 activation are commonly found in CRPC. Further investigation on their roles in PCa progression will help us to understand the incidence and mortality rate of PCa, and the disparities among ethnic and racial groups.

前列腺癌（PCa）是在非裔美国人中发现的流行疾病，并且是最常见的前列腺癌。 在美国男性中经常被诊断为癌症。非裔美国男性死于前列腺癌的比率高出2.39倍 与白人男性相比，所有癌症的平均死亡率仅高出1.34倍 这两个种族之间（癌症统计2010年）。手术、放射治疗和雄激素剥夺 已经开发并广泛应用治疗来控制PCa;然而，前列腺癌患者仍然死于 去势抵抗性前列腺癌（CRPC）。分子信号通路有助于启动和 PCa的进展;特别是，CRPC生长的机制仍有待阐明，以便开发 有效的癌症控制策略。Pten-PI 3 K-Akt通路的异常调节、p53丢失和Skp 2 在CRPC中常见活化。进一步研究它们在PCa进展中的作用将有助于我们 了解PCa的发病率和死亡率，以及种族和人种之间的差异。