Proteolytic Beacons in the Non-invasive Assessment of Response to Cancer Therapy
Proteolytic Beacons in the Non-invasive Assessment of Response to Cancer Therapy
批准号:
7490272
负责人:
LYNN M MATRISIAN
金额:
$10.45万
依托单位:
依托单位国家:
美国
项目类别:
财政年份:
2008
资助国家:
美国
项目状态:
已结题
起止时间:
2008-09-22 至 2013-08-31
关键词:
AEE 788Angiogenic FactorAnimalsAntibodiesBenignBiological AvailabilityBiometryBiostatistics CoreCell physiologyCellsCetuximabChemicalsChemistryChemotherapy-Oncologic ProcedureCleaved cellClinicalCollaborationsColorectal CancerComplementContrast MediaDataDepthDetectionDevelopmentDoseDyesEndopeptidasesEnergy TransferEnzymesEpidermal Growth Factor ReceptorEpidermal Growth Factor Receptor Tyrosine Kinase InhibitorEvaluationExperimental DesignsFamilyFamily memberFluorescenceGadoliniumGelatinase BGenerationsGoalsGrowth FactorHuman ResourcesImageIn VitroInfiltrationInflammatoryIntestinal NeoplasmsIntestinesInvasiveKnowledgeLaboratoriesLiteratureLiverMMP9 geneMagnetic Resonance ImagingMalignant - descriptorMalignant NeoplasmsMatrix MetalloproteinasesMediatingMetabolismMetalloendopeptidasesMetalloproteasesMicroscopyModelingMolecularMonitorMusNeoplasm MetastasisObject AttachmentOpticsPTK787Peptide HydrolasesPeptidesPhysiologyPlayProbabilityProteinsReadingReagentRegulationReporterResearchResearch PersonnelResolutionResourcesRoleSU11248SeriesSignal PathwaySolubilityStandards of Weights and MeasuresStatistical Data InterpretationSurrogate MarkersSystemTestingTherapeutic StudiesTimeTissuesToxic effectTrainingTumor Cell InvasionTumor VolumeTyrosine Kinase InhibitorVascular Endothelial Growth Factor ReceptorVertebral columnXenograft Modeladenomaaqueousbasecancer carecancer therapycellular imagingchemotherapeutic agentchemotherapycomplement C2adesignexperienceimaging probein vivoin vivo Cellular and Molecular Imaging Centersinhibitor/antagonistinterestmembermetastatic colorectalmouse modelnoveloptical imagingoptical switchresearch studyresidenceresponsesizetumortwo-photon
中文摘要
项目4由Lynn Matrisian博士和Wellington Pham博士领导,专注于开发光学信标和核磁共振
作为一种新机制的造影剂用于体内检测肿瘤相关金属蛋白酶活性
监测对肿瘤治疗的反应。基质金属蛋白酶(MMPs)家族成员参与了
与癌症侵袭相关的基质降解。有大量文献表明
特定的基质金属蛋白酶家族成员参与与癌症相关的特定细胞过程,包括
生长因子的激活、血管生成、炎性细胞的渗透和侵袭。这些调查人员
建议利用这一知识设计一系列非侵入性体内成像试剂,
将探测肿瘤的蛋白质分解状态,以帮助治疗决策,并快速评估对
标准的和有针对性的癌症化疗。范博士是一名训练有素的化学家,他带来了丰富的经验
通过设计和合成用于蛋白质分解活性的光学探针,癌症生物学家马特里西安博士已经
探索金属蛋白酶在小鼠癌症模型中的作用的丰富经验。小鼠模型的建立
良性、恶性和转移性结直肠癌将在这个项目中使用,对癌症的反应
针对表皮生长因子(EGF)受体轴的治疗将与
这项ICMIC提案的项目1和3。
英文摘要
Project 4, led by Drs. Lynn Matrisian and Wellington Pham, focuses on developing optical beacons and MRI
contrast agents for the in vivo detection of tumor-associated metalloproteinase activity as a novel mechanism
to monitor response to tumor therapy. Members of the matrix metalloproteinase (MMP) family are implicated in
the matrix degradation associated with cancer invasion. There is substantial literature indicating the
involvement of specific MMP family members in specific cellular processes related to cancer, including the
activation of growth factors, angiogenesis, infiltration of inflammatory cells, and invasion. These investigators
propose to take advantage of this knowledge to devise a series of non-invasive in vivo imaging reagents that
will probe the proteolytic status of a tumor to aid in treatment decisions, and rapidly assess the response to
standard and targeted cancer chemotherapies. Dr. Pham, a chemist by training, brings extensive experience
with the design and synthesis of optical probes for proteolytic activity, and Dr. Matrisian, a cancer biologist, has
extensive experience exploring the role of metalloproteinases in mouse models of cancer. Murine models of
benign, malignant, and metastatic colorectal cancer will be used in this project, and the response to cancer
therapies directed at the epidermal growth factor (EGF) receptor axis will be tested in collaboration with
projects 1 and 3 of this ICMIC proposal.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
Training
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批准号:8340449
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项目类别:
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资助金额:$20.17万
-
财政年份:2011
-
负责人:LYNN M MATRISIAN
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依托单位:
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批准号:8340447
-
项目类别:
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资助金额:$4.67万
-
财政年份:2011
-
负责人:LYNN M MATRISIAN
-
依托单位:
Cancer Outreach Core
-
批准号:8340442
-
项目类别:
-
资助金额:$15.61万
-
财政年份:2011
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负责人:LYNN M MATRISIAN
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依托单位:
Biostatistics Core
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批准号:8340441
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资助金额:$2.32万
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负责人:LYNN M MATRISIAN
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依托单位:
Molecular Mechanisms of SKP2 Targeting on Prostate Cancer Progression
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批准号:8340131
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项目类别:
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资助金额:$7.39万
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财政年份:2011
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负责人:LYNN M MATRISIAN
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依托单位:
A Multi-Center Epidemiologic Study of Breast Cancer in African-American Women
-
批准号:8340436
-
项目类别:
-
资助金额:$9.03万
-
财政年份:2011
-
负责人:LYNN M MATRISIAN
-
依托单位:
Planning and Evaluation Core
-
批准号:8340448
-
项目类别:
-
资助金额:$2.85万
-
财政年份:2011
-
负责人:LYNN M MATRISIAN
-
依托单位:
Administration Core
-
批准号:8340018
-
项目类别:
-
资助金额:$11.04万
-
财政年份:2011
-
负责人:LYNN M MATRISIAN
-
依托单位:
Host Microenvironment and Bone Metastases
-
批准号:7899992
-
项目类别:
-
资助金额:$35.01万
-
财政年份:2009
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负责人:LYNN M MATRISIAN
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依托单位:
Paracrine TGF-Beta Signaling in Tumor Initiation and Progression
-
批准号:7289826
-
项目类别:
-
资助金额:$149.21万
-
财政年份:2006
-
负责人:LYNN M MATRISIAN
-
依托单位:
Paracrine TGF-Beta Signaling in Tumor Initiation and Progression
-
批准号:7479307
-
项目类别:
-
资助金额:$150.02万
-
财政年份:2006
-
负责人:LYNN M MATRISIAN
-
依托单位:
Paracrine TGF-Beta Signaling in Tumor Initiation and Progression
-
批准号:7913503
-
项目类别:
-
资助金额:$5.26万
-
财政年份:2006
-
负责人:LYNN M MATRISIAN
-
依托单位:
Administrative Core
-
批准号:7243994
-
项目类别:
-
资助金额:$10.45万
-
财政年份:2006
-
负责人:LYNN M MATRISIAN
-
依托单位:
Paracrine TGF-Beta Signaling in Tumor Initiation and Progression
-
批准号:7232518
-
项目类别:
-
资助金额:$155.0万
-
财政年份:2006
-
负责人:LYNN M MATRISIAN
-
依托单位:
Paracrine TGF-Beta Signaling in Tumor Initiation and Progression
-
批准号:7496880
-
项目类别:
-
资助金额:$7.68万
-
财政年份:2006
-
负责人:LYNN M MATRISIAN
-
依托单位:
Paracrine TGF-Beta Signaling in Tumor Initiation and Progression
-
批准号:7899997
-
项目类别:
-
资助金额:$142.0万
-
财政年份:2006
-
负责人:LYNN M MATRISIAN
-
依托单位:
Paracrine TGF-Beta Signaling in Tumor Initiation and Progression
-
批准号:7679654
-
项目类别:
-
资助金额:$208.99万
-
财政年份:2006
-
负责人:LYNN M MATRISIAN
-
依托单位:
Paracrine TGF-Beta Signaling in Tumor Initiation and Progression
-
批准号:8127104
-
项目类别:
-
资助金额:$4.51万
-
财政年份:2006
-
负责人:LYNN M MATRISIAN
-
依托单位:
Training
-
批准号:6989653
-
项目类别:
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资助金额:$13.03万
-
财政年份:2004
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负责人:LYNN M MATRISIAN
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依托单位:
Small Animal MRI with Protease-Sensing Contrast Agents
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批准号:6952824
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项目类别:
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资助金额:$26.41万
-
财政年份:2004
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负责人:LYNN M MATRISIAN
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依托单位:
海外基金