Development of Mult-Spectral Fluorescence Scanning Fiber Endoscope (SFE)

多光谱荧光扫​​描纤维内窥镜（SFE）的研制

• 批准号: 8244093
• 负责人: Eric J Seibel
• 金额: $ 26.32万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-21 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8244093
• 关键词: Adenocarcinoma; Algorithms; Barrett Esophagus; Binding; Biopsy; Clinical; Clinical Research; Collection; Color; Coumarins; Custom; Detection; Development; Dysplasia; Early Diagnosis; Endoscopes; Esophageal; Esophagus; Fiber; Fluorescein; Fluorescein-5-isothiocyanate; Fluorescence; Future; Gene Targeting; Human Resources; Image; Individual; Label; Light; Maps; Measures; Medical; Michigan; Neoplasms; Pathology; Patients; Peptides; Performance; Phase; Physicians; Protocols documentation; Resolution; Safety; Scanning; Screening for cancer; Screening procedure; Signal Transduction; Site; Surface; System; Testing; Time; Training; Universities; Validation; Variant; Washington; Work; alpha benzopyrone; base; cost; design; fluorescence imaging; image processing; improved; in vitro testing; in vivo; instrument; prototype; surveillance strategy; validation studies

Project Summary: A multi-spectral scanning fiber endoscope (SFE) will be developed to image the panel of fluorescent-labeled pepfides developed in Project 2 that have specific binding activity to amplified and/or over expressed gene targets identifled in Project 1. Image processing algorithms will be developed to stitch together individual images to form a panorama of the esophageal mucosal surface, and "red-flag" idenfificafion of highgrade dysplasia and early adenocarcinoma will be performed in Core B to assist the physician by guiding biopsy. The performance of this integrated imaging strategy will be validated in Core C. This instrument will pass through the working channel of a medical endoscope in Phase 1 clinical studies of the individual pepfides assigned to three fiuorescent-labels in Project 2. The expected establishment of safety will prepare this system for a future multi-center clinical validation study.

项目摘要：将开发一种多光谱扫描光纤内窥镜（SFE），以对项目2中开发的荧光标记肽组进行成像，这些肽对项目1中鉴定的扩增和/或过表达基因靶标具有特异性结合活性。将开发图像处理算法，将单个图像拼接在一起，形成食管粘膜表面的全景图，并在核心B中对高度异型增生和早期腺癌进行“红旗”活检，以通过引导活检来协助医生。该集成成像策略的性能将在核心C中得到验证。在单个pepfides的I期临床研究中，该仪器将通过医用内窥镜的工作通道 分配给项目2中的三个荧光标记。安全性的预期确立将为该系统未来的多中心临床验证研究做好准备。