Development of Mult-Spectral Fluorescence Scanning Fiber Endoscope (SFE)

多光谱荧光扫​​描纤维内窥镜（SFE）的研制

• 批准号: 8555332
• 负责人: Eric J Seibel
• 金额: $ 22.87万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-09-21 至 2016-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8555332
• 关键词: Algorithms; Binding; Clinical; Clinical Research; Color; Coumarins; Custom; Development; Endoscopes; Esophageal; Esophagus; Fiber; Fluorescein; Fluorescein-5-isothiocyanate; Fluorescence; Gene Targeting; Human Resources; Image; Individual; Label; Michigan; Pathology; Peptides; Performance; Phase; Resolution; Scanning; Screening for cancer; Surface; System; Testing; Training; Universities; Washington; Work; alpha benzopyrone; base; design; fluorescence imaging; image processing; in vitro testing; in vivo; instrument; prototype

A multi-spectral scanning fiber endoscope (SFE) will be developed to image the panel of fluorescent-labeled peptides developed in Project 2 that have specific binding activity to amplified and/or over expressed gene targets identified in Project 1. Image processing algorithms will be developed to stitch together individual images to form a panorama of the esophageal mucosal surface, and

将开发一种多光谱扫描光纤内窥镜（SFE）来对面板进行成像 在项目2中开发的荧光标记肽，其对扩增和/或过度扩增具有特异性结合活性。 在项目1中确定的表达基因靶点。将开发图像处理算法， - 单独的图像，以形成食管粘膜表面的全景，以及