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Multispectral near-infrared imaging of dental caries in children

儿童龋齿的多光谱近红外成像

基本信息

批准号：
9230389
负责人：
Eric J Seibel
金额：
$ 14.69万
依托单位：
UNIVERSITY OF WASHINGTON
依托单位国家：
美国
项目类别：
财政年份：
2016
资助国家：
美国
起止时间：
2016-03-01 至 2018-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9230389
关键词：
12 year old Address Adolescent Adult Age Alaska Native Algorithms Area Bitewing Radiography Caliber Child Childhood Chronic Chronic Disease Clinic Clinical Collection Color Communicable Diseases Country Dental Dental Care Dental Enamel Dental Technicians Dental caries Dentists Detection Devices Diagnosis Diagnostic Diagnostic radiologic examination Endoscopes Environment Equipment Exposure to Fiber Goals Hand Health Histology Image Imaging Device In Vitro Industry Ions Lasers Lead Lesion Letters Light Lighting Location Measurement Measures Metals Methods Monitor Native-Born Neighborhoods Optics Oral cavity Oral health Orthodontic Pain Palpation Parents Pediatric Dentistry Pediatric Hospitals Persons Pilot Projects Population Population Group Positioning Attribute Preschool Child Preventive Preventive measure Procedures Research Resolution Risk Roentgen Rays Running Rural Scanning Severities Surface Technology Telecommunications Telemedicine Testing Therapeutic Three-Dimensional Imaging Time Tissues Tooth Diseases Tooth structure Training Universities Visible Radiation Visual Washington Work accurate diagnosis base contrast imaging cost detector efficacy study health care disparity health disparity high resolution imaging imaging modality in vivo instrument nano novel therapeutics operation optical fiber optical imaging portability prototype public health relevance quantitative imaging sensor transmission process underserved minority

项目摘要

DESCRIPTION (provided by applicant): Dental caries is one of the most common chronic infectious diseases in the world. The occlusal (biting surface) and interproximal (between teeth) areas are where there need for quantitative imaging of tooth decay and depth of cracks in the USA. In addition a majority of the caries load in USA is carried by different groups, such as Alaska Native people who have many times the national rate of tooth decay. Health care disparities in this population are exacerbated by rural remoteness. The average number of dental fillings per Alaskan Native person is double that of urban dwellers. To provide safe, high-quality dental care in these remote areas, an x- ray replacement is desired which provides high-resolution optical images of cracks and decay deep within teeth that does not require ionizing x-ray radiation. The current problem is that the optimal wavelengths of infrared light (1310 and 1460 nm) that can be used to see decay in teeth, do not have small high-resolution cameras for pediatric clinical use. Thus, an alternative method of forming infrared images will be developed and tested that produces the highest contrast of the lesion, which is scanning laser light either i transmission, reflection, and in a right-angle configuration (for example, scan the occlusal surface and detect above the gum line). The smallest laser-based imaging device has been developed at the University of Washington (UW), being the diameter of a round toothpick (1.2-mm) while producing high-quality video images at multiple wavelengths. The scanning fiber endoscope (SFE) technology has been tested by Dr. Joel Berg in children at The Center for Pediatric Dentistry with shared administration from UW Pediatric Dentistry and Children's Hospital, Seattle, WA. Although this device used visible light for testing the health of the enamel the change to infrared is straightforward, allowing much deeper imaging of cracks and carious lesions using optimal laser wavelengths for high-contrast transmittance and reflectance imaging. The small size of the scanner allows the two imaging modes to run concurrently if needed to find the extent of a crack, maximum depth of caries, and even total volume of caries under surveillance with non-surgical medicinal therapies. The hand piece will be smaller than any bitewing radiographic sensor used in children now, while providing new features of imaging during restorative work, possibly under tele-medicine conditions. The SFE technology is fundamentally low in cost because it uses laser and detectors that are fully developed in the telecommunications industry. The low- power scanned laser light imaging can be made portable and carries no significant risks. This project will fabricate a prototype device, determine its optimal imaging modes (wavelength &configuration), develop new 3D imaging algorithms, test with extracted teeth and verify with a pilot study with children 6 to 12 years of age.

描述（申请人提供）：龋齿是世界上最常见的慢性传染病之一。在美国，咬合面（咬合面）和邻间（牙齿之间）区域需要定量成像蛀牙和裂缝深度。此外，美国的大部分龋齿负荷由不同的群体承担，例如阿拉斯加土著人，他们的蛀牙率是全国的许多倍。偏远的农村地区加剧了这一人口在保健方面的差距。阿拉斯加原住民每人补牙的平均数量是城市居民的两倍。为了在这些偏远地区提供安全、高质量的牙齿护理，需要一种X射线替代品，其提供牙齿深处的裂纹和龋齿的高分辨率光学图像，而不需要电离X射线辐射。目前的问题是，可用于查看牙齿腐烂的红外光的最佳波长（1310和1460 nm）没有用于儿科临床使用的小型高分辨率相机。因此，将开发和测试形成红外图像的替代方法，其产生病变的最高对比度，其是以透射、反射和直角配置扫描激光（例如，扫描咬合面并检测牙龈线上方）。华盛顿大学（UW）已经开发出最小的基于激光的成像设备，直径为圆形牙签（1.2毫米），同时在多个波长下产生高质量的视频图像。扫描光纤内窥镜（SFE）技术已经由Joel贝格博士在儿童牙科中心进行了测试，并与华盛顿大学儿童牙科和儿童医院（西雅图）共享管理。虽然该设备使用可见光来测试釉质的健康状况，但红外线的变化是直接的，可以使用最佳激光波长对裂缝和龋损进行更深的成像，以实现高对比度的透射率和反射率成像。扫描仪的小尺寸允许两种成像模式同时运行，如果需要找到裂缝的程度，龋齿的最大深度，甚至在非手术药物治疗的监测下的龋齿总量。该手机将比目前儿童使用的任何咬翼式射线照相传感器都要小，同时在修复工作期间提供新的成像功能，可能在远程医疗条件下。SFE技术的成本基本上很低，因为它使用的激光器和探测器在电信行业已经得到了充分的发展。低功率扫描激光成像可以制成便携式的，并且没有重大风险。该项目将制造一个原型设备，确定其最佳成像模式（波长和配置），开发新的3D成像算法，用拔出的牙齿进行测试，并在6至12岁的儿童中进行试点研究。