Multispectral near-infrared imaging of dental caries in children
儿童龋齿的多光谱近红外成像
基本信息
- 批准号:9230389
- 负责人:
- 金额:$ 14.69万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2016
- 资助国家:美国
- 起止时间:2016-03-01 至 2018-08-31
- 项目状态:已结题
- 来源:
- 关键词:12 year oldAddressAdolescentAdultAgeAlaska NativeAlgorithmsAreaBitewing RadiographyCaliberChildChildhoodChronicChronic DiseaseClinicClinicalCollectionColorCommunicable DiseasesCountryDentalDental CareDental EnamelDental TechniciansDental cariesDentistsDetectionDevicesDiagnosisDiagnosticDiagnostic radiologic examinationEndoscopesEnvironmentEquipmentExposure toFiberGoalsHandHealthHistologyImageImaging DeviceIn VitroIndustryIonsLasersLeadLesionLettersLightLightingLocationMeasurementMeasuresMetalsMethodsMonitorNative-BornNeighborhoodsOpticsOral cavityOral healthOrthodonticPainPalpationParentsPediatric DentistryPediatric HospitalsPersonsPilot ProjectsPopulationPopulation GroupPositioning AttributePreschool ChildPreventivePreventive measureProceduresResearchResolutionRiskRoentgen RaysRunningRuralScanningSeveritiesSurfaceTechnologyTelecommunicationsTelemedicineTestingTherapeuticThree-Dimensional ImagingTimeTissuesTooth DiseasesTooth structureTrainingUniversitiesVisible RadiationVisualWashingtonWorkaccurate diagnosisbasecontrast imagingcostdetectorefficacy studyhealth care disparityhealth disparityhigh resolution imagingimaging modalityin vivoinstrumentnanonovel therapeuticsoperationoptical fiberoptical imagingportabilityprototypepublic health relevancequantitative imagingsensortransmission processunderserved minority
项目摘要
DESCRIPTION (provided by applicant): Dental caries is one of the most common chronic infectious diseases in the world. The occlusal (biting surface) and interproximal (between teeth) areas are where there need for quantitative imaging of tooth decay and depth of cracks in the USA. In addition a majority of the caries load in USA is carried by different groups, such as Alaska Native people who have many times the national rate of tooth decay. Health care disparities in this population are exacerbated by rural remoteness. The average number of dental fillings per Alaskan Native person is double that of urban dwellers. To provide safe, high-quality dental care in these remote areas, an x- ray replacement is desired which provides high-resolution optical images of cracks and decay deep within teeth that does not require ionizing x-ray radiation. The current problem is that the optimal wavelengths of infrared light (1310 and 1460 nm) that can be used to see decay in teeth, do not have small high-resolution cameras for pediatric clinical use. Thus, an alternative method of forming infrared images will be developed and tested that produces the highest contrast of the lesion, which is scanning laser light either i transmission, reflection, and in a right-angle configuration (for example, scan the occlusal surface and detect above the gum line). The smallest laser-based imaging device has been developed at the University of Washington (UW), being the diameter of a round toothpick (1.2-mm) while producing high-quality video images at multiple wavelengths. The scanning fiber endoscope (SFE) technology has been tested by Dr. Joel Berg in children at The Center for Pediatric Dentistry with shared administration from UW Pediatric Dentistry and Children's Hospital, Seattle, WA. Although this device used visible light for testing the health of the enamel the change to infrared is straightforward, allowing much deeper imaging of cracks and carious lesions using optimal laser wavelengths for high-contrast transmittance and reflectance imaging. The small size of the scanner allows the two imaging modes to run concurrently if needed to find the extent of a crack, maximum depth of caries, and even total volume of caries under surveillance with non-surgical medicinal therapies. The hand piece will be smaller than any bitewing radiographic sensor used in children now, while providing new features of imaging during restorative work, possibly under tele-medicine conditions. The SFE technology is fundamentally low in cost because it uses laser and detectors that are fully developed in the telecommunications industry. The low- power scanned laser light imaging can be made portable and carries no significant risks. This project will fabricate a prototype device, determine its optimal imaging modes (wavelength &configuration), develop new 3D imaging algorithms, test with extracted teeth and verify with a pilot study with children 6 to 12 years of age.
描述(申请人提供):龋齿是世界上最常见的慢性传染病之一。在美国,咬合面(咬合面)和邻间(牙齿之间)区域需要定量成像蛀牙和裂缝深度。此外,美国的大部分龋齿负荷由不同的群体承担,例如阿拉斯加土著人,他们的蛀牙率是全国的许多倍。偏远的农村地区加剧了这一人口在保健方面的差距。阿拉斯加原住民每人补牙的平均数量是城市居民的两倍。为了在这些偏远地区提供安全、高质量的牙齿护理,需要一种X射线替代品,其提供牙齿深处的裂纹和龋齿的高分辨率光学图像,而不需要电离X射线辐射。目前的问题是,可用于查看牙齿腐烂的红外光的最佳波长(1310和1460 nm)没有用于儿科临床使用的小型高分辨率相机。因此,将开发和测试形成红外图像的替代方法,其产生病变的最高对比度,其是以透射、反射和直角配置扫描激光(例如,扫描咬合面并检测牙龈线上方)。华盛顿大学(UW)已经开发出最小的基于激光的成像设备,直径为圆形牙签(1.2毫米),同时在多个波长下产生高质量的视频图像。扫描光纤内窥镜(SFE)技术已经由Joel贝格博士在儿童牙科中心进行了测试,并与华盛顿大学儿童牙科和儿童医院(西雅图)共享管理。虽然该设备使用可见光来测试釉质的健康状况,但红外线的变化是直接的,可以使用最佳激光波长对裂缝和龋损进行更深的成像,以实现高对比度的透射率和反射率成像。扫描仪的小尺寸允许两种成像模式同时运行,如果需要找到裂缝的程度,龋齿的最大深度,甚至在非手术药物治疗的监测下的龋齿总量。该手机将比目前儿童使用的任何咬翼式射线照相传感器都要小,同时在修复工作期间提供新的成像功能,可能在远程医疗条件下。SFE技术的成本基本上很低,因为它使用的激光器和探测器在电信行业已经得到了充分的发展。低功率扫描激光成像可以制成便携式的,并且没有重大风险。该项目将制造一个原型设备,确定其最佳成像模式(波长和配置),开发新的3D成像算法,用拔出的牙齿进行测试,并在6至12岁的儿童中进行试点研究。
项目成果
期刊论文数量(2)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
Near-Infrared Imaging of Artificial Enamel Caries Lesions with a Scanning Fiber Endoscope
使用扫描纤维内窥镜对人工牙釉质龋损进行近红外成像
- DOI:10.3390/s19061419
- 发表时间:2019
- 期刊:
- 影响因子:3.9
- 作者:Lee, Robert;Zhou, Yaxuan;Finkleman, Sara;Sadr, Alireza;Seibel, Eric
- 通讯作者:Seibel, Eric
Near-infrared multispectral endoscopic imaging of deep artificial interproximal lesions in extracted teeth: NEAR-INFRARED MULTISPECTRAL ENDOSCOPIC IMAGING
拔牙深部人工邻间病变的近红外多光谱内窥镜成像:近红外多光谱内窥镜成像
- DOI:10.1002/lsm.23065
- 发表时间:2019
- 期刊:
- 影响因子:2.4
- 作者:Zhou, Yaxuan;Lee, Robert C.;Finkleman, Sara;Sadr, Alizera;Seibel, Eric J.
- 通讯作者:Seibel, Eric J.
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
数据更新时间:{{ journalArticles.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ monograph.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ sciAawards.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ conferencePapers.updateTime }}
{{ item.title }}
- 作者:
{{ item.author }}
数据更新时间:{{ patent.updateTime }}
Eric J Seibel其他文献
Eric J Seibel的其他文献
{{
item.title }}
{{ item.translation_title }}
- DOI:
{{ item.doi }} - 发表时间:
{{ item.publish_year }} - 期刊:
- 影响因子:{{ item.factor }}
- 作者:
{{ item.authors }} - 通讯作者:
{{ item.author }}
{{ truncateString('Eric J Seibel', 18)}}的其他基金
Rapid Needle Biopsy Assessment at Point of Care to advance personalized cancer therapy
护理点快速针活检评估以推进个性化癌症治疗
- 批准号:
9886701 - 财政年份:2020
- 资助金额:
$ 14.69万 - 项目类别:
Multiplexed imaging of biliary intra-epithelial neoplasia
胆道上皮内瘤变的多重成像
- 批准号:
9110227 - 财政年份:2015
- 资助金额:
$ 14.69万 - 项目类别:
Needle biopsy preservation and preparation for rapid 3D pathology of pancreas
胰腺快速 3D 病理学针吸活检保存和准备
- 批准号:
9115080 - 财政年份:2014
- 资助金额:
$ 14.69万 - 项目类别:
Needle biopsy preservation and preparation for rapid 3D pathology of pancreas
胰腺快速 3D 病理学针吸活检保存和准备
- 批准号:
8737000 - 财政年份:2014
- 资助金额:
$ 14.69万 - 项目类别:
Needle biopsy preservation and preparation for rapid 3D pathology of pancreas
胰腺快速 3D 病理学针吸活检保存和准备
- 批准号:
8912438 - 财政年份:2014
- 资助金额:
$ 14.69万 - 项目类别:
NRI: Advanced Biophotonics for Image-guided Robotic Surgery
NRI:用于图像引导机器人手术的先进生物光子学
- 批准号:
8511630 - 财政年份:2012
- 资助金额:
$ 14.69万 - 项目类别:
NRI: Advanced Biophotonics for Image-guided Robotic Surgery
NRI:用于图像引导机器人手术的先进生物光子学
- 批准号:
8717419 - 财政年份:2012
- 资助金额:
$ 14.69万 - 项目类别:
NRI: Advanced Biophotonics for Image-guided Robotic Surgery
NRI:用于图像引导机器人手术的先进生物光子学
- 批准号:
8458644 - 财政年份:2012
- 资助金额:
$ 14.69万 - 项目类别:
NRI: Advanced Biophotonics for Image-guided Robotic Surgery
NRI:用于图像引导机器人手术的先进生物光子学
- 批准号:
8917217 - 财政年份:2012
- 资助金额:
$ 14.69万 - 项目类别:
Development of Mult-Spectral Fluorescence Scanning Fiber Endoscope (SFE)
多光谱荧光扫描纤维内窥镜(SFE)的研制
- 批准号:
8555332 - 财政年份:2011
- 资助金额:
$ 14.69万 - 项目类别:
相似海外基金
Enhancing Structural Competency in School-Based Health Centers to Address LGBTQ+ Adolescent Health Equity
增强校本健康中心的结构能力,以解决 LGBTQ 青少年健康公平问题
- 批准号:
10608426 - 财政年份:2023
- 资助金额:
$ 14.69万 - 项目类别:
Application and feasability of a brief digital screening tool to address parental and adolescent tobacco and electronic cigarette use in pediatric medical care - a pilot study
简短的数字筛查工具的应用和可行性,以解决儿科医疗中父母和青少年烟草和电子烟的使用问题 - 一项试点研究
- 批准号:
486580 - 财政年份:2022
- 资助金额:
$ 14.69万 - 项目类别:
Studentship Programs
Co-design of an intervention to address alcohol use among adolescent boys and young men in Tanzania
共同设计一项干预措施,解决坦桑尼亚青春期男孩和年轻男性的饮酒问题
- 批准号:
MR/V032380/1 - 财政年份:2022
- 资助金额:
$ 14.69万 - 项目类别:
Research Grant
Complex intervention to optimise adolescent BMI pre-conception to address the double burden of malnutrition: A RCT in rural and urban South Africa
优化青少年孕前体重指数以解决营养不良的双重负担的复杂干预措施:南非农村和城市的随机对照试验
- 批准号:
MR/V005790/1 - 财政年份:2021
- 资助金额:
$ 14.69万 - 项目类别:
Research Grant
Application of a brief digital screening tool to address parental and adolescent tobacco and electronic cigarette use in pediatric medical care
应用简短的数字筛查工具来解决儿科医疗中父母和青少年烟草和电子烟的使用问题
- 批准号:
455984 - 财政年份:2021
- 资助金额:
$ 14.69万 - 项目类别:
Operating Grants
Complex intervention to optimise adolescent BMI pre-conception to address the double burden of malnutrition: A RCT in rural and urban South Africa
优化青少年孕前体重指数以解决营养不良的双重负担的复杂干预措施:南非农村和城市的随机对照试验
- 批准号:
MR/V005790/2 - 财政年份:2021
- 资助金额:
$ 14.69万 - 项目类别:
Research Grant
Development of the Cannabis Actions and Practices (CAP): A Parent-Focused Intervention to Address Adolescent Marijuana Use
大麻行动和实践 (CAP) 的发展:以家长为中心的干预措施,解决青少年大麻使用问题
- 批准号:
10057761 - 财政年份:2020
- 资助金额:
$ 14.69万 - 项目类别:
Development of the Cannabis Actions and Practices (CAP): A Parent-Focused Intervention to Address Adolescent Marijuana Use
大麻行动和实践 (CAP) 的发展:以家长为中心的干预措施,解决青少年大麻使用问题
- 批准号:
10213683 - 财政年份:2020
- 资助金额:
$ 14.69万 - 项目类别:
Targeted interventions to address the multi-level effects of gender-based violence on PrEP uptake and adherence among adolescent girls and young women in Kenya
有针对性的干预措施,以解决性别暴力对肯尼亚少女和年轻妇女接受和坚持 PrEP 的多层面影响
- 批准号:
9403567 - 财政年份:2017
- 资助金额:
$ 14.69万 - 项目类别:
Designing targeted interventions to address HIV vulnerabilities and improve clinical outcomes among conflict affected adolescent girls and young women under 25 in Northern Uganda
设计有针对性的干预措施,以解决乌干达北部受冲突影响的少女和 25 岁以下年轻妇女的艾滋病毒脆弱性并改善临床结果
- 批准号:
356145 - 财政年份:2016
- 资助金额:
$ 14.69万 - 项目类别:
Operating Grants














{{item.name}}会员




