Dissemination & Implementation (D&l) Methods Core

核心摘要 缩小科学发现和在临床实践中应用有效干预措施之间的差距，以及 以广泛的人群为基础的癌症预防和控制战略，以证据为基础的转移 必须通过战略传播和实施(D8il)努力得出结论；还反映了一种需要 贯穿整个NCI领导国家的战略计划。关于以下方面的专门知识和专业知识 成功的D&L对这项任务至关重要。TREC D&L方法核心将为 推动个人研究项目的科学发现沿着临床研究的方向发展 连续体(即T L)。T2)以及在社区和社区中广泛的基于人口的应用。 此外，核心的跨学科重点将强调D&L在TREC项目和核心之间的联系。 这些活动将支持应用TRECs多层次办法的知识和经验 推进与能量平衡、肥胖和预防相互作用的研究和实践， 癌症的诊断和治疗。例如，核心将与项目1(Moley)合作，以转移经验教训 关于营养对癌症易感性影响的跨代动物模型 项目2(Wolin)中关于能量平衡和前列腺癌治疗结果的研究以及项目4 (霍夫曼)为肥胖和癌症建立模型，将社会决定因素联系起来。核心的首要目标是 加快TREC研究在多个层面上对科学和公共卫生的影响。要做到这一点 目标，具体目标是：目标1：提高TREC跨学科研究项目的D&L能力 目标2：通过D&L的研究工作，传播世界科技大学和中国医学科学院的跨学科研究成果；目标2：确定具体的方法和工具，以加强传播世界科技大学和中国医学科学院在能量平衡、肥胖和癌症方面的跨学科发现；以及目标3：应用有效的战略，传播和实施世界科技大学和中国医学科学院和中国医学科学院的循证发现，并将其应用到临床和公共卫生实践中。核心将由埃诺拉·普罗科特领导。在核心教员的协作下，以及TREC领导层和行政部门以及内部和外部科学顾问委员会的广泛指导下，获得博士学位。这一核心的教职员工领导已经证明：1)在研究设计、实施和评估中使用最先进的方法；2)D&L研究；3)大型项目的有效管理。评估核心的指标：关键流程指标将包括每月联系人数、每月咨询时间、提交的D&L研究申请以及进行的培训。影响措施将包括D&L在高影响场所的出版物数量、D&L拨款以及使用循证战略控制癌症的项目。较长期的结果措施包括采用和维持以证据为基础的癌症控制方法。在这一核心的发展阶段，成果指标不太可能改变，但基础设施将到位，以便以后跟踪长期 措施。

Core Summary To close the gap between scientific discovery and application of effective interventions in clinical practice and to broad population-based strategies for the prevention and control of cancer, the transfer of evidence-based findings must be made through strategic Dissemination and Implementation (D8il) efforts; a need also reflected throughout the NCI Strategic Plan for Leading the Nation. Specific knowledge and expertise regarding successful D&l is essential to this mission. The TREC D&l Methods Core will provide an incubator for advancing the movement of scientific findings from individual research projects along the clinical research continuum (i.e. T l . T2) and to broad population-based application in communities and neighborhoods. Additionally, the Core's transdisciplinary focus will emphasize D&l linkage across TREC projects and cores. These activities will support the application of knowledge and experience from the TRECs multilevel approach to advance both research and practice related to the interaction of energy balance, obesity and the prevention, diagnosis and treatment of cancer. For example, the core will work with Project 1 (Moley) to transfer lessons about transgenerational animal models of nutritional impact on cancer predisposition to infiuences being studied in Project 2 (Wolin) about energy balance and prostate cancer treatment outcomes and Project 4 (Hovman) to model obesity and cancer linking social determinants. The Core's overarching goal is to accelerate the scientific and public health impact of TREC research across multiple levels. To achieve this goal, specific aims are: Aim 1: To increase the D&l capacity of TREC research projects across transdisciplinary areas of WUSTL and the SCC through D&l research efforts; Aim 2: To identify specific approaches and tools to enhance the dissemination of transdisciplinary discoveries of WUSTL and SCC related to energy balance, obesity and cancer; and Aim 3: To apply effective strategies to disseminate and implement evidence-based discoveries from the TREC and transdisciplinary collaborations of WUSTL and SCC into clinical and public health practice. The Core will be led by Enola Proctor. PhD with collaboration of core faculty and broad direction from TREC Leadership and Administration and Internal and External Scientific Advisory Boards. The faculty leaders in this core have already demonstrated: 1) use of state-of-the-art methods in study design, implementation, and evaluation; 2) D&l research; and 3) effective management of large-scale projects. Metrics for evaluating the core: Key process measures will include the number of contacts per month, consultation hours per month, D&l research applications submitted, and trainings conducted. Impact measures will include the number of D&l publications in high impact venues, D&l grants funded, and projects using evidence-based strategies for cancer control. Longer-term outcome measures include the adoption and maintenance of evidence-based approaches to cancer control. Outcome indicators are not likely to be changed during the developmental phase of this core but the infrastructure will be put in place for later tracking of long-term measures.