Administrative Core

印第安纳州儿科药理学中心(ICPP)是一个由多学科研究人员组成的高度协作的小组，他们在一起工作了近十年，卓有成效。它的研究重点是生殖系基因组学对儿童药物有效性和安全性的影响。该中心代表着一种高效的跨学科协作模式，对这一调查领域产生了重大影响，并生成了大量支持这一应用程序的初步数据。这个 管理核心涉及五个关键领导人：弗洛克哈特博士。伦巴格。哈尼琳。罗伯逊和比斯。这个领导小组对核心提供密切的战略监督，该核心由ICPP PI伦巴格博士和弗洛克哈特博士管理。核心项目的目标是：1)组织ICPP项目和核心内部和之间的沟通，包括：作为财务管理的沟通结构，维护所有中央文件，组织协作性手稿和提案编写，维护定期会议和电话会议时间表；2)组织生物统计和建模核心三个项目与基因分型和分析实验室之间的有效数据流动。这一核心是管理产生的大量数据的核心，并负责这些数据的审计和质量控制：它是IPCC研究中心的协调引擎。所有由项目产生的临床、基因组、蛋白质组和体外数据都被发送到核心，在那里它们被存储在caArray安全数据管理系统中，然后被发送到生物统计和建模核心进行分析，因为数据是从特定的项目和试点产生的。行政核心为所有项目服务，是项目与生物统计和建模核心之间沟通的主要组织者。核心还负责协调和组织这些调查人员的广泛定期互动。这些会议包括国家和国际科学会议、每周电话/网络会议、每月执行委员会会议和与我们的科学咨询委员会的年度务虚会。

The Indiana Center for Pediatric Pharmacology (ICPP) is a highly collaborative group of multidisciplinary investigators that have worked together productively for almost a decade. Its research has focused on the effects of germ line genomics on the efficacy and safety of medications for children. The center represents a highly productive model of interdisciplinary collaboration, that has significantly impacted this field of investigation, and generated a large amount of preliminary data that support this application. The Administrative Core involves five key leaders: Drs Flockhart. Renbarger. Haneline. Robertson and Bies. This leadership group provides close, strategic oversight of the Core, which is managed by Drs. Renbarger and Flockhart, the ICPP PIs. The Aims of the core are: 1) To organize communication within and between the ICPP projects and cores, including: serving as a communication structure for fiscal management, maintaining all central documents, organizing collaborative manuscript and proposal preparation, and maintaining of regular meeting and teleconference schedule; and 2) To organize the effective flow of curated data between the three projects, the Biostatistics and Modeling Core, and the genotyping and analytical labs. This Core is central to the management of the large amounts of data generated, and is responsible for the auditing and quality control of that data: it is the coordinating engine at the center of the IPCC's research. All clinical, genomic, proteomic, and in vitro data generated from projects are sent to the core, where they are stored in the caArray secure data management system before being sent to the Biostatistics and Modeling Core for analysis as data are generated from specific projects and pilots. The Administrative Core serves all projects and is the key organizer of communication between the projects and the Biostatistics and Modeling core. The Core is also responsible for the coordination and organization of the wide range of regular interactions of these investigators. These include national and international scientific meetings, weekly phone/web conferences, monthly executive committee meetings and yearly retreats with our scientific advisory committee.