Relationship between vaginal micobiota and T. vaginalis acquisition

阴道微生物群与阴道毛滴虫获取的关系

• 批准号: 8300621
• 负责人: Olamide Daphna Jarrett
• 金额: $ 12.16万
• 依托单位: UNIVERSITY OF ILLINOIS AT CHICAGO
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-01 至 2015-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8300621
• 关键词: Address; African; Bacteria; Bacterial Vaginosis; Behavioral; Biological Assay; Biology; Caring; Case-Control Studies; Chicago; Clinic; Clinical; Collaborations; Communicable Diseases; Communities; Consumption; Country; Data; Developing Countries; Development; Diagnosis; Ecology; Environment; Epidemiologic Studies; Epidemiology; Equilibrium; Faculty; Fellowship; Female; Fostering; Funding; Genital system; Goals; Gram' s stain; HIV; HIV-1; Health; Health Policy; Illinois; Individual; Infection; Infection prevention; Internal Medicine; International; Kenya; Laboratory Research; Lactobacillus; Link; Medical center; Mentors; Methods; Nested Case-Control Study; Nutrient; Outcome; Pathogenesis; Patients; Pelvic Inflammatory Disease; Phagocytosis; Physicians; Predisposition; Pregnancy; Premature Labor; Prevention Research; Prevention strategy; Public Health; Public Sector; Research; Research Infrastructure; Research Personnel; Residencies; Resources; Risk; Risk Factors; Rural; Scientist; Sexually Transmitted Diseases; Site; Source; Techniques; Trichomonas; Trichomonas Infections; Trichomonas vaginalis; United States National Institutes of Health; Universities; Unsafe Sex; Vagina; Visit; Washington; Woman; Work; adverse outcome; base; career; career development; case control; experience; innovation; interest; novel; professor; prospective; rRNA Genes; research and development; routine Bacterial stain; transmission process; vaginal lactobacilli

DESCRIPTION (provided by applicant): Candidate: Olamide Jarrett, MD, MPH is an Assistant Professor in Infectious Diseases at the University of Illinois at Chicago (UIC). She received her BA in biology from Harvard University and MD from the University of Chicago. She completed a residency in Internal Medicine at UIC and a fellowship in Infectious Diseases at Tufts Medical Center. During her fellowship Dr. Jarrett had her initial experience in international HIV/STI (sexually transmitted infection) research, investigating clinical outcomes in HIV-infected patients receiving care in a rural public sector clinic. Her current research interests are in HIV/STI prevention, with a special interest in sub-Saharan African women. Her immediate career goal is to gain additional educational and research experience in the field of STI epidemiology in developing countries, especially as it relates to HIV/STI prevention in women. Dr. Jarrett's long-term objective is to become a productive NIH-funded physician- scientist conducting practical and innovative HIV/STI prevention research in resource-limited countries. Environment and educational plan: UIC is dedicated to the career development of new investigators and in fostering collaborations to expand research opportunities for its faculty. Dr. Jarrett will work wih Dr. Scott McClelland, MD, MPH from the University of Washington (UW), who will serve as her primary mentor for this proposal. In addition, she will work with UIC-based mentors, Drs. Richard Novak and Robert Bailey, who will oversee her research and career development activities at UIC. Her research will be conducted at the Mombasa field site, which Dr. McClelland has been the director of since 2002. The Mombasa field site provides an excellent research environment, an established research laboratory and administrative infrastructure. Many large epidemiologic studies have been successfully completed at the site since it was established in 1993. The proposed educational plan includes work in Kenya, advanced studies in HIV/STI research at UW and UIC, as well as advanced studies in epidemiology and health policy at UIC. Research Plan: Trichomonas vaginalis is the most prevalent curable STI. Additional data are needed to understand the epidemiology of T. vaginalis in the female genital tract. This case-control study will address the interaction between T. vaginalis and vaginal flora by evaluating: 1) the change in total vaginal Lactobacillus spp concentration and total vaginal bacterial load after T. vaginalis infection, and 2) the association between baseline total vaginal bacteria load and T. vaginalis acquisition. We will use non-culture based techniques to assess vaginal bacteria concentrations, which is novel to the study of interactions between vaginal flora and STIs. Behavioral, sexual, and microbiological risk factors that may impact vaginal bacterial concentrations will be studied, in order to develop a comprehensive understanding of the interaction between vaginal flora of study and T. vaginalis. The results of this study will inform the development of T. vaginalis prevention strategies aimed at the promotion of healthy vaginal flora. PUBLIC HEALTH RELEVANCE: Trichomonas vaginalis, the most prevalent treatable STI, is associated with an increased risk of adverse outcomes in women, including preterm labor, pelvic inflammatory disease and HIV-1 transmission. Reducing women's risk of T. vaginalis infection could serve as an important strategy for reducing the rates of these complications. The proposed aims will contribute to our understanding of the interaction between vaginal bacterial flora and T. vaginalis, which will inform the development of public health strategies aimed at the promotion of healthy vaginal bacterial profiles to reduce women's susceptibility to T. vaginalis infection.

描述（由申请人提供）：候选人：MD的Olamide Jarrett，MPH是伊利诺伊大学芝加哥大学（UIC）的传染病助理教授。她获得了哈佛大学的生物学学士学位和芝加哥大学的医学博士学位。她在UIC完成了内科住院医师，并在Tufts医疗中心获得了传染病研究金。在奖学金期间 在农村公共部门诊所接受护理。她目前的研究兴趣是艾滋病毒/性传播感染预防，对撒哈拉以南非洲妇女特别感兴趣。她的直接职业目标是在发展中国家的STI流行病学领域获得额外的教育和研究经验，尤其是与女性预防HIV/STI有关。 Jarrett博士的长期目标是成为一名由NIH资助的富有成效的医师 - 在资源有限的国家进行实践和创新的HIV/STI预防研究。环境和教育计划：UIC致力于新调查人员的职业发展，并促进合作，以扩大其教师的研究机会。 Jarrett博士将在华盛顿大学（UW）的MPH上为Scott McClelland博士工作，后者将担任该建议的主要导师。此外，她还将与基于UIC的导师Drs合作。理查德·诺瓦克（Richard Novak）和罗伯特·贝利（Robert Bailey）将监督UIC的研究和职业发展活动。她的研究将在蒙巴萨现场进行，麦克莱兰德博士自2002年以来一直担任该现场。蒙巴萨现场现场提供了一个很好的研究环境，这是一个既定的研究实验室和行政基础设施。自1993年成立以来，该站点已成功完成了许多大型流行病学研究。拟议的教育计划包括在肯尼亚的工作，UW和UIC的HIV/STI研究高级研究以及UIC的流行病学和健康政策的高级研究。研究计划：阴道毛毛虫是最普遍的可治愈性传播感染。需要其他数据来了解女性生殖道中阴道的流行病学。这项病例对照研究将通过评估来解决阴道和阴道菌群之间的相互作用：1）阴道乳杆菌SPP浓度和阴道感染后阴道总细菌负荷的变化，以及2）基线总阴道细菌负荷和T. t. t. faginalis摄取。我们将使用基于非培养的技术来评估阴道细菌浓度，这是对阴道菌群和性传播菌之间相互作用的新颖新颖的。将研究可能影响阴道细菌浓度的行为，性和微生物危险因素，以便对阴道菌群与阴道菌与阴道菌之间的相互作用进行全面的了解。这项研究的结果将为旨在促进健康阴道菌群的预防植物预防策略的发展提供信息。 公共卫生相关性：最普遍的可治疗性传播感染Trichomonas Vaginalis与女性不良后果的风险增加有关，包括早产，骨盆炎性疾病和HIV-1传播。降低女性阴道感染的风险可能是降低这些并发症发生率的重要策略。拟议的目标将有助于我们理解阴道细菌菌群和阴道菌之间的相互作用，这将为旨在促进健康的阴道细菌特征的公共卫生策略的制定提供信息，以减少妇女对阴道感染的敏感性。