Relationship between vaginal micobiota and T. vaginalis acquisition

描述（由申请人提供）：候选人：Olamide Jarrett，医学博士，公共卫生硕士是在芝加哥伊利诺伊大学（UIC）传染病助理教授。她获得了哈佛大学生物学学士学位和芝加哥大学医学博士学位。她在UIC完成了内科住院医师培训，并在塔夫茨医疗中心获得了传染病奖学金。在她的研究期间，Jarrett博士在国际HIV/STI（性传播感染）研究中获得了初步经验，调查了HIV感染患者的临床结果 在农村公共部门诊所接受治疗。她目前的研究兴趣是艾滋病毒/性传播感染的预防，特别是在撒哈拉以南非洲妇女的兴趣。她的近期职业目标是在发展中国家的性病流行病学领域获得更多的教育和研究经验，特别是因为它涉及到妇女的艾滋病毒/性病预防。Jarrett博士的长期目标是成为一名富有成效的NIH资助的医生-科学家，在资源有限的国家开展实用和创新的艾滋病毒/性传播感染预防研究。环境和教育计划：UIC致力于新研究人员的职业发展，并促进合作，以扩大其教师的研究机会。Jarrett博士将与来自华盛顿大学（UW）的医学博士Scott McClelland博士合作，后者将担任该提案的主要导师。此外，她将与UIC的导师Richard Novak博士和Robert Bailey博士合作，他们将监督她在UIC的研究和职业发展活动。她的研究将在蒙巴萨现场进行，麦克莱兰博士自2002年以来一直担任该现场的主任。蒙巴萨实地提供了极好的研究环境、成熟的研究实验室和行政基础设施。自1993年建立以来，许多大型流行病学研究已在该中心成功完成。拟议的教育计划包括在肯尼亚的工作，在华盛顿大学和国际学院进行艾滋病毒/性传播感染研究方面的高级研究，以及在国际学院进行流行病学和卫生政策方面的高级研究。研究计划：阴道毛滴虫是最普遍的可治愈性传播感染。需要更多的数据来了解T.女性生殖道中的迷走神经。本病例对照研究将探讨T。阴道和阴道植物群的变化：1）T.阴道感染，和2）基线总阴道细菌负荷和T。迷走神经获得我们将使用非培养技术来评估阴道细菌浓度，这是研究阴道植物群和STI之间相互作用的新方法。将研究可能影响阴道细菌浓度的行为、性和微生物学风险因素，以全面了解研究的阴道植物群与T.流浪汉本研究结果将为T.旨在促进健康阴道植物群的阴道炎预防策略。

DESCRIPTION (provided by applicant): Candidate: Olamide Jarrett, MD, MPH is an Assistant Professor in Infectious Diseases at the University of Illinois at Chicago (UIC). She received her BA in biology from Harvard University and MD from the University of Chicago. She completed a residency in Internal Medicine at UIC and a fellowship in Infectious Diseases at Tufts Medical Center. During her fellowship Dr. Jarrett had her initial experience in international HIV/STI (sexually transmitted infection) research, investigating clinical outcomes in HIV-infected patients receiving care in a rural public sector clinic. Her current research interests are in HIV/STI prevention, with a special interest in sub-Saharan African women. Her immediate career goal is to gain additional educational and research experience in the field of STI epidemiology in developing countries, especially as it relates to HIV/STI prevention in women. Dr. Jarrett's long-term objective is to become a productive NIH-funded physician- scientist conducting practical and innovative HIV/STI prevention research in resource-limited countries. Environment and educational plan: UIC is dedicated to the career development of new investigators and in fostering collaborations to expand research opportunities for its faculty. Dr. Jarrett will work wih Dr. Scott McClelland, MD, MPH from the University of Washington (UW), who will serve as her primary mentor for this proposal. In addition, she will work with UIC-based mentors, Drs. Richard Novak and Robert Bailey, who will oversee her research and career development activities at UIC. Her research will be conducted at the Mombasa field site, which Dr. McClelland has been the director of since 2002. The Mombasa field site provides an excellent research environment, an established research laboratory and administrative infrastructure. Many large epidemiologic studies have been successfully completed at the site since it was established in 1993. The proposed educational plan includes work in Kenya, advanced studies in HIV/STI research at UW and UIC, as well as advanced studies in epidemiology and health policy at UIC. Research Plan: Trichomonas vaginalis is the most prevalent curable STI. Additional data are needed to understand the epidemiology of T. vaginalis in the female genital tract. This case-control study will address the interaction between T. vaginalis and vaginal flora by evaluating: 1) the change in total vaginal Lactobacillus spp concentration and total vaginal bacterial load after T. vaginalis infection, and 2) the association between baseline total vaginal bacteria load and T. vaginalis acquisition. We will use non-culture based techniques to assess vaginal bacteria concentrations, which is novel to the study of interactions between vaginal flora and STIs. Behavioral, sexual, and microbiological risk factors that may impact vaginal bacterial concentrations will be studied, in order to develop a comprehensive understanding of the interaction between vaginal flora of study and T. vaginalis. The results of this study will inform the development of T. vaginalis prevention strategies aimed at the promotion of healthy vaginal flora.