THE UNIVERSITY OF ROCHESTER CLINICAL AND TRANSLATIONAL SCIENCE INSTITUTE

本分项目是CTSA供资的估计百分比，即 被用于广泛的研究领域(艾滋病研究、儿科研究或 临床试验)。列出的总成本仅是对CTSA金额的估计 用于这一研究领域的基础设施，而不是由 授予子项目或子项目工作人员的NCRR补助金。 描述(由申请者提供)：罗切斯特临床和转化科学奖(RCTSA)计划建议继续其双重目标：1)在学术机构--罗切斯特大学临床和转化科学研究所(UR-CTSI)内组织、支持和扩大罗切斯特大学的临床和转化研究；2)整合和合作地区和国家机构，扩大国家临床和转化研究网络。RCTSA项目真正改变了罗切斯特大学医学中心(URMC)，建造了一座最先进的临床和转化科学大楼，将临床和转化科学整合到URMC研究的共同愿景中，建立了成功的动态治理系统，扩大了研究资源，并热情地参与和领导了国家CTSA联盟。为了继续保持这一势头，乌鲁木齐兹-CTSI将实现一些具体目标。首先，将实施三个新的关键功能：公私合作伙伴关系、T1翻译和比较有效性研究。现有的主要职能将进行重组和合并，通过扩大监管支助办公室、导航/咨询服务和合并试点研究、新颖方法和翻译技术关键职能的孵化器计划，为调查人员提供更好的支持。CTSI将在研究翻译领域建立和培育四个卓越的研究中心：人类实验治疗中心(T1研究)；临床研究中心(T1-3研究)；研究实施和翻译中心(护理学院赞助的T2-3研究)；以及社区卫生中心(T2-3研究)。广泛的教育、培训和职业发展计划将继续满足研究人员的需求。UR-CTSI将积极参与国家CTSA联盟，分享专业知识、方法、数据和课程。纽约州北部的翻译研究网络(UNYTRN)将扩大，以支持该地区的生物医学研究机构。最后，将通过衡量严格的绩效结果来评估UR-CTSI。 公共卫生相关性(由申请者提供)：UR临床和转化科学研究所(UR-CTSI)将成为将基本发现转化为人类应用和临床试验的焦点，并以证据为基础实施有效的临床实践和有效的社区战略。UR-CTSI将成为护理、牙科和其他学科参与CTSA的典范，使罗切斯特社区参与研究的所有方面，并在研究翻译方面与地区生物医学机构合作。

This subproject represents an estimate of the percentage of the CTSA funding that is being utilized for a broad area of research (AIDS research, pediatric research, or clinical trials). The Total Cost listed is only an estimate of the amount of CTSA infrastructure going towards this area of research, not direct funding provided by the NCRR grant to the subproject or subproject staff. DESCRIPTION (provided by applicant): The Rochester Clinical and Translational Science Award (RCTSA) Program proposes continuation of its dual goals: 1) To organize, support, and expand clinical and translational research at the University of Rochester within an academic home, the University of Rochester Clinical and Translational Science Institute (UR-CTSI), and 2) To integrate and collaborate with regional and national institutions to expand a National Clinical and Translational Research Network. The RCTSA Program has truly transformed the University of Rochester Medical Center (URMC), with the construction of a state-of-the-art Clinical and Translational Science Building, the integration of clinical and translational science into the shared vision for URMC research, a successful system of dynamic governance, expansion of research resources, and enthusiastic participation and leadership in the National CTSA Consortium. To continue this momentum, the UR-CTSI will carry out a number of specific aims. First, three new key functions will be implemented: Public-Private Partnerships, T1 Translation, and Comparative Effectiveness Research. Existing Key Functions will be reorganized and consolidated to provide better support of investigators by an expanded Office of Regulatory Support, a Navigator/Consultation Service, and an Incubator Program consolidating Pilot Studies, Novel Methodologies, and Translational Technologies Key Functions. The CTSI will establish and foster four centers of research excellence across the spectrum of research translation: Center for Human Experimental Therapeutics (T1 Research); Clinical Research Center (T1-3 Research); Center for Research Implementation and Translation (T2-3 research under School of Nursing sponsorship); and Center for Community Health (T2-3 research). A broad range of education, training, and career development programs will continue to meet research workforce needs. The UR-CTSI will be an active participant in the National CTSA consortium with sharing of expertise, methods, data, and curricula. The Upstate New York Translational Research Network (UNYTRN) will be expanded to support the region's biomedical research institutions. Finally, the UR-CTSI will be evaluated through the measurement of rigorous performance outcomes. PUBLIC HEALTH RELEVANCE (provided by applicant): The UR Clinical and Translational Science Institute (UR-CTSI) will be the focal point for translation of basic discoveries to human applications and clinical trials, and for evidence-based implementation of efficacious clinical practices and effective community strategies. The UR-CTSI will be a model for CTSA involvement of nursing, dentistry, and other disciplines, for engagement of the Rochester community in all aspects of research and for collaboration with regional biomedical institutions in research translation.