Southwest Oncology Group Biorepository

描述（由申请人提供）：西南肿瘤小组生物标本库的总体目标是支持增加收集、存储和获取高质量、有良好注释的人类标本，这些标本来自nci资助的临床试验的患者群体，并具有代表性。提供这种基础设施的总体科学目标是开发更好的癌症预后和预测标志物，改善分子分期，了解治疗耐药机制，确定新的假定治疗靶点，并制定新的治疗策略。这些目标是通过广泛的多学科努力来实现的，这些努力依赖于获得来自不同人群的高质量、特征明确的生物标本，并汇集了SWOG成员及其附属机构以及SWOG外部个人的临床、实验室和科学专业知识。这些活动严重依赖于有才能的调查人员、病理学家、生物标本库以及生物标本库与提交机构、业务办公室、统计中心、调查人员和NCI之间的密切工作关系。将根据SWOG翻译科学评审过程收到的提案的科学价值发放样本。

DESCRIPTION (provided by applicant): The overall general goals of the Southwest Oncology Group Biospecimen Repository is to support the increased collection of, storage of and access to high-quality, well-annotated human specimens collected from and representative of the patient populations entered into NCI-funded clinical trials. The overall scientific goal in providing this infrastructure is to develop improved prognostic and predictive markers for cancer, to improve molecular staging, to understand mechanisms of treatment resistance, to identify new putative therapeutic targets, and to develop novel therapeutic strategies. These goals are addressed through broad-based multidisciplinary efforts that rely on access to high quality, well characterized biospecimens from diverse population groups and that bring together clinical, laboratory and scientific expertise from within SWOG membership and its affiliates, as well as from individuals outside of SWOG. These activities critically rely on talented investigators, pathologists, biospecimen banks and close working relationships of the biorepository with the submitting institutions, the Operations Office, Statistical Center, investigators and the NCI. Specimens will be released based on the scientific merit of the proposals received via SWOG Translation Science Review process.