Core A: Administrative Core

核心A--行政核心：项目摘要/摘要 行政核心负责领导和管理遗传学和基因组学 平滑肌肉瘤(LMS)：对癌症生物学认识的提高和诊断和治疗的新方法 处理孢子。这个核心的领导应对孢子中出现的挑战和机遇 每周的网络研讨会、面对面的小组会议和持续的进展报告。目标是确保项目合作- 领导人和他们的调查人员在实现他们的目标方面正在取得进展，这些核心正在提供 确保实现整体翻译目标所需的支持。行政核心将监督 职业提升(CEP)和发展研究(DRP)计划，通过建立期望和 帮助克服挑战，使这些计划履行其重要使命，实施有效的计划 招募早期职业调查员，并确定有前途的、创新的发展项目。核心领导层将 负责根据需要协调外部咨询委员会(EAB)会议和电话会议，以确保 选管会会随时向选管会汇报工作进展，以及任何需要他们提供意见的挑战。 平滑肌肉瘤(LMS)为合作的孢子项目提供了一个理想的机会，该项目将 杰出的实验室和临床翻译科学家，他们的集体目标是更好地理解 平滑肌肉瘤和改进治疗。这项工作将对其他肉瘤亚型具有更广泛的相关性 包括未分化多形性肉瘤和骨肉瘤。为这笔赠款而组建的团队已经 在过去的三年里，在慈善支持下共同致力于LMS的重点研究。《校长》 调查员和Core联席主任在过去18年多的时间里在合作研究方面进行了合作 密歇根大学和一个学术研究联盟的项目。作为研究的领导者 Baker博士、Schuetze博士和Reinke女士拥有所需的技能和理解 汇聚多机构团队，促进合作研究取得成功。领导班子 将由密歇根大学医学院的赠款管理基础设施提供行政支持 有效管理国立卫生研究院拨款的学校，不仅在大学内，而且在合作的学术领域 机构，一个与这笔赠款的组织相一致的结构。 孢子调查员意识到与以下方面相关的挑战、资源需求和潜在陷阱 这种协作研究的进行和这些挑战通过让成熟的 该团队的协作基础设施。我们创建了一个灵活、高度交互的管理核心 通过合作制定研究计划，严格监测进展，并进行调整 迅速实施，以实现改善肉瘤患者护理和预后的孢子目标。

Core A - Administrative Core: Project Summary / Abstract The Administrative Core is responsible for leadership and management of the Genetics and Genomics of Leiomyosarcoma (LMS): Improved understanding of cancer biology and new approaches to diagnosis and treatment SPORE. The leadership of this Core addresses challenges and opportunities arising in the SPORE weekly webinars, in-person group meetings and ongoing progress reports. The aim is to ensure Project co- leaders and their investigators are making progress in achieving their aims and that the Cores are providing the needed support to ensure overall translational goals are achieved. The Administrative Core will oversee the Career Enhancement (CEP) and Developmental Research (DRP) Programs, by establishing expectations and helping overcome challenges, such that these programs fulfill their vital missions to implement effective plans to recruit early career investigators and identify promising, innovative developmental projects. Core leadership will be responsible for coordinating the External Advisory Board (EAB) meetings and calls as needed to ensure the EAB is kept informed of progress as well as any challenges requiring their advice. Leiomyosarcoma (LMS) provides an ideal opportunity for a collaborative SPORE program that brings together exceptional laboratory and clinical translational scientists with the collective goal of better understanding leiomyosarcoma and improving treatment. This work will have broader relevance to other sarcoma sub-types including undifferentiated pleomorphic sarcoma and osteosarcoma. The team assembled for this grant has been working together on LMS focused research with philanthropic support for the past 3 years. The Principal Investigators and Core Co-Director have worked together over the past 18+ years on collaborative research projects at the University of Michigan and within an academic research consortium. As leaders in the research consortium, Dr. Baker, Dr. Schuetze and Ms. Reinke have the skills and understanding of what is needed to bring a multi-institutional team together and facilitate collaborative research successfully. The leadership team will be administratively supported by the grant management infrastructure at the University of Michigan Medical School which effectively manages NIH grant funding not only at the University but across collaborative academic institutions, a structure aligned with the organization of this grant. The SPORE investigators are aware of the challenges, resource requirements and potential pitfalls relevant to the conduct of this collaborative research and these challenges are mitigated by engaging the well-established collaborative infrastructure of this team. We have created a flexible, highly interactive Administrative Core whereby research plans are collaboratively developed, progress is rigorously monitored, and adjustments are rapidly implemented so as to realize the SPORE goals of improved sarcoma patient care and outcomes.