Core A: Administrative Core

核心A -行政核心：项目摘要/摘要 行政核心负责遗传学和基因组学的领导和管理， 平滑肌肉瘤（LMS）：提高对癌症生物学的理解和诊断的新方法， 治疗孢子。该核心的领导层应对SPORE中出现的挑战和机遇 每周网络研讨会、面对面小组会议和持续进展报告。其目的是确保项目的合作， 领导人和他们的调查人员正在实现他们的目标方面取得进展，核心正在提供 所需的支持，以确保实现整体的翻译目标。行政核心将监督 职业提升（CEP）和发展研究（DRP）计划，通过建立期望和 帮助克服挑战，使这些方案履行其重要使命，实施有效的计划， 招募早期职业调查员，并确定有前途的创新发展项目。核心领导层将 负责协调外部咨询委员会（EAB）会议和电话，以确保 EAB随时了解进展情况以及需要其建议的任何挑战。 平滑肌肉瘤（LMS）提供了一个理想的机会，合作孢子计划，汇集 卓越的实验室和临床转化科学家，共同目标是更好地了解 平滑肌肉瘤和提高治疗水平。这项工作将有更广泛的相关性，其他肉瘤亚型 包括未分化多形性肉瘤和骨肉瘤。为这项资助而组建的团队 在过去的3年里，我们在慈善机构的支持下共同致力于LMS重点研究。校长 研究人员和核心联合主任在过去18年多的合作研究中共同努力 项目在密歇根大学和一个学术研究联盟。作为研究的领导者， 贝克博士，Schuetze博士和Reinke女士拥有所需的技能和理解， 将多机构团队聚集在一起，并成功促进合作研究。领导班子 将由密歇根大学医学院的赠款管理基础设施提供行政支持 有效管理NIH赠款资金的学校不仅在大学，而且在合作学术 机构，一个与该赠款的组织相一致的结构。 SPORE调查人员了解与以下方面相关的挑战、资源要求和潜在缺陷： 这种合作研究的进行和这些挑战是通过参与完善的 这个团队的基础设施。我们创建了一个灵活的、高度互动的管理核心 通过合作制定研究计划，严格监控进展，并进行调整， 快速实施，以实现改善肉瘤患者护理和结果的SPORE目标。

Core A - Administrative Core: Project Summary / Abstract The Administrative Core is responsible for leadership and management of the Genetics and Genomics of Leiomyosarcoma (LMS): Improved understanding of cancer biology and new approaches to diagnosis and treatment SPORE. The leadership of this Core addresses challenges and opportunities arising in the SPORE weekly webinars, in-person group meetings and ongoing progress reports. The aim is to ensure Project co- leaders and their investigators are making progress in achieving their aims and that the Cores are providing the needed support to ensure overall translational goals are achieved. The Administrative Core will oversee the Career Enhancement (CEP) and Developmental Research (DRP) Programs, by establishing expectations and helping overcome challenges, such that these programs fulfill their vital missions to implement effective plans to recruit early career investigators and identify promising, innovative developmental projects. Core leadership will be responsible for coordinating the External Advisory Board (EAB) meetings and calls as needed to ensure the EAB is kept informed of progress as well as any challenges requiring their advice. Leiomyosarcoma (LMS) provides an ideal opportunity for a collaborative SPORE program that brings together exceptional laboratory and clinical translational scientists with the collective goal of better understanding leiomyosarcoma and improving treatment. This work will have broader relevance to other sarcoma sub-types including undifferentiated pleomorphic sarcoma and osteosarcoma. The team assembled for this grant has been working together on LMS focused research with philanthropic support for the past 3 years. The Principal Investigators and Core Co-Director have worked together over the past 18+ years on collaborative research projects at the University of Michigan and within an academic research consortium. As leaders in the research consortium, Dr. Baker, Dr. Schuetze and Ms. Reinke have the skills and understanding of what is needed to bring a multi-institutional team together and facilitate collaborative research successfully. The leadership team will be administratively supported by the grant management infrastructure at the University of Michigan Medical School which effectively manages NIH grant funding not only at the University but across collaborative academic institutions, a structure aligned with the organization of this grant. The SPORE investigators are aware of the challenges, resource requirements and potential pitfalls relevant to the conduct of this collaborative research and these challenges are mitigated by engaging the well-established collaborative infrastructure of this team. We have created a flexible, highly interactive Administrative Core whereby research plans are collaboratively developed, progress is rigorously monitored, and adjustments are rapidly implemented so as to realize the SPORE goals of improved sarcoma patient care and outcomes.