National Consortium on Alcohol and NeuroDevelopment in Adolescence: Duke

全国酒精与青春期神经发育联盟：杜克大学

• 批准号: 8412987
• 负责人: Michael Damingo De Bellis
• 金额: $ 73.36万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-09-01 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8412987
• 关键词: Abstinence; Address; Adolescence; Adolescent; Adult; Adverse effects; Affect; Affective; Age; Alcohol consumption; Alcohol or Other Drugs use; Alcoholic Intoxication; Alcoholic beverage heavy drinker; Alcoholism; Alcohols; Anatomy; Area; Behavioral; Behavioral inhibition; Brain; Brain imaging; California; Cerebrum; Characteristics; Childhood; Clinical assessments; Cognitive; Communities; DNA; Data; Dependence; Development; Diagnostic; Diffusion Magnetic Resonance Imaging; Dose; Drug usage; Family history of; Foundations; Functional Magnetic Resonance Imaging; Future; Goals; Heavy Drinking; Human; Imaging Techniques; Incentives; International; Longitudinal Studies; Magnetic Resonance Imaging; Measures; Mental Health; Monitor; Neurobiology; Neurocognitive; Neuropsychological Tests; Outcome; Pattern; Population; Prefrontal Cortex; Prevention; Protocols documentation; Psychopathology; Recovery; Recruitment Activity; Regulation; Reporting; Research; Resolution; Rest; Rewards; Risk; Risk Factors; Role; Saccades; Sampling; Site; Sleep Stages; Subgroup; Substance Use Disorder; System; Teenagers; Universities; Visit; Youth; adolescent alcohol; alcohol abstinence; alcohol and other drug; alcohol consequences; alcohol effect; alcohol exposure; alcohol use disorder; base; disorder risk; drinking; follow-up; frontal lobe; genetic analysis; high risk; longitudinal design; medical specialties; neurodevelopment; neuroimaging; neuropsychological; psychobiologic; psychologic; relating to nervous system; response; sex; underage drinking; white matter; young adult

DESCRIPTION (provided by applicant): In response to RFA-AA-12-006, this application proposes the Duke Research Component of the National Consortium on Alcohol and Neurodevelopment in Adolescence (NCANDA: DUKE) to determine the effects of alcohol use on the developing adolescent brain. Recruited at ages 12 through 21, a high risk enhanced community sample of 170 Duke subjects (N=680 from all sites) will complete a baseline assessment and undergo three annual follow-up assessments in an accelerated longitudinal design. At each visit, a multimodal magnetic resonance imaging (MRI) protocol, comprehensive neuropsychological battery, and assessments of alcohol and other substance use and related problems, mental health symptomatology, and substance use disorder risk factors will be measured. Brain imaging includes state-of-the-art high resolution structural MRI (sMRI), diffusion tensor imaging (DTI), and resting state MRI (rsMRI). The examination of alcohol consequences will focus on structural and functional maturation of brain areas that are actively developing during adolescence, involved in psychological regulation, responsive to rewards, and thought to be vulnerable to toxic alcohol effects. In addition, NCANDA: Duke will collaborate on two supplemental studies. We will collaborate with NCANDA: Pittsburgh in a study utilizing functional MRI to examine cerebral activation during a reward modulated anti-saccade task to study alcohol effects on reward responding and behavioral inhibition. We will also collaborate with NCANDA: UCSD to study a subgroup who will undergo a recovery protocol to attempt to successfully keep youth abstinent from substances for 4-6 weeks and measure recovery of neural and neurocognitive status and function. Studied in the context of risks and baseline brain characteristics, we will determine both the effects of alcohol exposure on the developmental trajectory of the adolescent human brain, and identify preexisting psychobiological vulnerabilities that may put an adolescent at elevated risk for an alcohol use disorder. PUBLIC HEALTH RELEVANCE: The National Consortium on Alcohol and Neurodevelopment in Adolescence (N-CANDA) will use multimodal brain imaging, neuropsychological testing and clinical assessments in a large adolescents sample followed over four years to determine neurodevelopmental risks for problematic alcohol use and alcohol effects on adolescent brain development. In addition to contributing to this goal, N-CANDA: Duke will also determine the effects of adolescent alcohol use on the neurobiological foundations of behavioral inhibition and a subgroup who will undergo a recovery protocol to attempt to successfully keep youth abstinent from substances for 4-6 weeks and measure recovery of neural and neurocognitive status and function. This information may be used to advance the prevention and treatment of adolescent alcohol use disorders.

描述（由申请人提供）：为了回应 RFA-AA-12-006，本申请建议国家青少年酒精与神经发育联盟的杜克研究部分（NCANDA：DUKE）确定饮酒对青少年大脑发育的影响。在 12 岁至 21 岁之间招募的 170 名杜克大学受试者（来自所有地点的 N=680 名）的高风险增强社区样本将完成基线评估，并以加速纵向设计进行三年年度随访评估。每次就诊时，都会测量多模态磁共振成像 (MRI) 方案、综合神经心理学电池、酒精和其他物质使用及相关问题的评估、心理健康症状和物质使用障碍风险因素。脑成像包括最先进的高分辨率结构 MRI (sMRI)、扩散张量成像 (DTI) 和静息态 MRI (rsMRI)。对酒精后果的检查将重点关注青春期期间活跃发育的大脑区域的结构和功能成熟度，这些区域参与心理调节，对奖励做出反应，并且被认为容易受到有毒酒精的影响。此外，NCANDA：杜克大学将合作开展两项补充研究。我们将与匹兹堡 NCANDA 合作进行一项研究，利用功能性 MRI 来检查奖赏调节反眼跳任务期间的大脑激活，以研究酒精对奖赏反应和行为抑制的影响。我们还将与 NCANDA：加州大学圣地亚哥分校合作，研究一个亚组，该亚组将接受恢复方案，试图成功地让青少年戒除物质 4-6 周，并测量神经和神经认知状态和功能的恢复情况。在风险和基线大脑特征的背景下进行研究，我们将确定酒精暴露对青少年人类大脑发育轨迹的影响，并确定先前存在的心理生物学脆弱性，这些脆弱性可能使青少年面临酒精使用障碍的高风险。 公共健康相关性：国家青少年酒精和神经发育联盟 (N-CANDA) 将在四年多的时间内对大量青少年样本进行多模式脑成像、神经心理学测试和临床评估，以确定有问题的饮酒的神经发育风险以及酒精对青少年大脑发育的影响。除了为实现这一目标做出贡献外，N-CANDA：杜克大学还将确定青少年饮酒对行为抑制的神经生物学基础的影响，并确定一个小组将接受恢复方案，试图成功地让青少年戒酒 4-6 周，并测量神经和神经认知状态和功能的恢复情况。该信息可用于推进青少年酒精使用障碍的预防和治疗。