Real-time detection of neurochemical changes in response to alcohol drinking

实时检测饮酒后神经化学变化

• 批准号: 8451975
• 负责人: DAVE JOHNSON
• 金额: $ 37.01万
• 依托单位: PINNACLE TECHNOLOGY, INC
• 依托单位国家: 美国
• 财政年份: 2010
• 资助国家: 美国
• 起止时间: 2010-09-30 至 2013-03-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8451975
• 关键词: Acetylcholine; Acute; Alcohol consumption; Alcohol dependence; Animals; Biosensor; Brain; Brain region; Chronic; Contracts; Coupled; Detection; Development; Devices; Disease; Dopamine; Ethanol; Event; Future; Glutamates; Goals; In Vitro; Kinetics; Marketing; Measurement; Mediating; Methods; Monitor; Mus; National Institute on Alcohol Abuse and Alcoholism; Pharmaceutical Preparations; Phase; Physiology; Rattus; Reporting; Research Personnel; Resolution; Rodent; Small Business Innovation Research Grant; Specificity; System; Testing; Time; Wireless Technology; Work; alcohol abuse therapy; alcohol effect; alcohol response; base; design; drinking; gamma-Aminobutyric Acid; in vivo; interest; manufacturing process; neurochemistry; prototype; sensor

Under Phase I of this SBIR Fast-track project, a base manufacturing process to produce a reliable, robust ethanol biosensor will be developed and the feasibility of the biosensor, capable of real-time monitoring of ethanol, will be demonstrated and a functional prototype ethanol biosensor will be delivered. During Phase II, the biosensor design prototype and multi-sensor array (a three-channel wireless potentiostat for rats) will be finalized and the manufacturing process will be optimized. The biosensor will be validated in vitro and in vivo and introduced to the commercial market.

在该SBIR快速通道项目的第一阶段，将开发一种生产可靠，耐用的乙醇生物传感器的基础制造工艺，并证明能够实时监测乙醇的生物传感器的可行性，并将提供功能原型乙醇生物传感器。 在第二阶段，将完成生物传感器设计原型和多传感器阵列（用于大鼠的三通道无线恒电位仪），并优化制造过程。该生物传感器将在体外和体内进行验证，并引入商业市场。