ELECTROPHYSIOLOGICAL STUDIES OF ACUTE AND CHRONIC ALCOHOL CONSUMPTION

急性和慢性饮酒的电生理学研究

• 批准号: 3817401
• 负责人: J ROHRBAUGH
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3817401
• 关键词: alcoholic beverage consumption; alcoholism /alcohol abuse; alcoholism /alcohol abuse therapy; blood chemistry; brain electrical activity; cognition; dosage; electrophysiology; human subject; human therapy evaluation; interview; neuropsychology; performance; peripheral nervous system; psychophysiology; sensorimotor system; toxicology

Although alcohol clearly leads to alterations in mental processes and behavior, it is perhaps because these effects are so great and so pervasive that they have proven difficult to characterize. The global performance measures commonly used to document such effects, while demonstrating clearly their presence, often provide little information as to the specific locus or mechanism of effect. The present research aims to parse the separate effects of alcohol on peripheral nerve, sensory, cognitive and motor systems using event related brain electrical potentials. These potentials are studied within a broad context provided by performance, psychophysiological, neuropsychological, neuroradiological and neuropsychiatric data. The effects of alcohol are investigated in three classes of subjects: 1) The effects of acute administration are examined in normal volunteers with respect to dose-response relationships, the temporal course of effect, and relationship to blood alcohol levels; 2) Brain electrical activity is studied, in conjunction with neuropsychological data, in social drinkers in an attempt to assay the effects of moderate levels of alcohol consumption; 3) Abstaining alcoholics, including those with alcoholism-related mental impairment, are studied to characterize the deficits, to examine the short- and long-term recovery effects, if any, during abstinence, and to examine the efficacy of various treatment strategies.

尽管酒精明显会导致心理过程的改变 和行为，也许是因为这些影响太大了 它们如此普遍，以至于很难描述它们的特征。 这 通常用于记录此类影响的全球绩效衡量标准， 虽然清楚地展示了他们的存在，但通常很少提供 有关特定位点或作用机制的信息。 这 目前的研究旨在解析酒精对身体的单独影响 使用事件的周围神经、感觉、认知和运动系统 相关脑电势。 研究了这些潜力 在性能提供的广泛背景下， 心理生理学、神经心理学、神经放射学和 神经精神数据。 酒精的影响分为三类： 受试者： 1) 急性给药的影响在 正常志愿者在剂量反应关系方面， 影响的时间过程以及与血液酒精的关系 级别； 2) 结合研究脑电活动 利用神经心理学数据，对社交饮酒者进行研究，试图 分析适度饮酒的影响； 3） 戒酒，包括那些与酗酒有关的人 精神障碍，被研究来描述缺陷的特征， 检查短期和长期恢复效果（如果有） 禁欲，并检查各种治疗的效果 策略。