ELECTROPHYSIOLOGICAL STUDIES OF ACUTE AND CHRONIC ALCOHOL CONSUMPTION

急性和慢性饮酒的电生理学研究

• 批准号: 3808652
• 负责人: J ROHRBAUGH
• 金额: --
• 依托单位: NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/3808652
• 关键词: alcoholic beverage consumption; alcoholism /alcohol abuse; alcoholism /alcohol abuse therapy; autonomic nervous system; blood chemistry; brain electrical activity; child (0-11); cognition; dosage; drug adverse effect; electrophysiology; human subject; human therapy evaluation; interview; neuropsychology; performance; peripheral nervous system; psychophysiology; sensorimotor system

The aim of this research is to study the covert brain processes that underlie cognition and performance in human subjects, and the acute and chronic effects of ethanol upon such processes. Included is an extensive study in which we are examining brain processes in individuals with different family histories of alcoholism. A principal focus of these studies is the measurement of brain electrical potentials, which provide information regarding the timing and character of the constituent sensory, cognitive and motor elements that are the mechanisms underlying observable behavior. The study of the brain potentials also allows inference of the specific brain regions affected by ethanol . The brain electrical potentials are studied within a broad context provided by performance and psychometric data, and measurement within other psychophysiological response systems. We have obtained data which document a large number of acute and chronic effects on specific brain functions, ranging from sensory input to motor control functions. Of particular interest is a finding that brain electrical and autonomic signs of alerting and orienting are enhanced by ethanol, in contrast to its depressant effect on most other functions. A similar effect was observed in a sample of chronic alcoholics organic brain disorder patients. Such findings suggest that ethanol intoxication and alcoholic organic brain disease may be associated with a disinhibition or deregulation of orienting processes. The attendant fragmentation associated with alcohol.

这项研究的目的是研究隐蔽的大脑过程 人类受试者的认知和行为基础，以及敏锐和 乙醇对这些过程的慢性影响。其中包括一个广泛的 在这项研究中，我们正在研究患有脑部疾病的人的大脑过程 有不同的酗酒家族史。这些活动的一个主要关注点 研究是对大脑电位的测量，它提供了 关于组成感官的时间和特征的信息， 认知和运动元素，它们是可观察到的机制 行为。对大脑电位的研究也可以推断出 受酒精影响的特定大脑区域。脑电波 潜力是在一个广泛的背景下研究的， 心理测量数据，以及其他心理生理学内的测量 响应系统。 我们已经获得了记录大量急性和慢性疾病的数据 对特定大脑功能的影响，从感觉输入到运动 控制功能。特别有趣的是一项发现，大脑 通过以下方式增强警示和定向的电气和自主信号 乙醇，与其对大多数其他功能的抑制作用相反。一个 在慢性酒精中毒的器质性脑中也观察到了类似的效果。 精神障碍患者。这些发现表明，酒精中毒和 酒精性器质性脑病可能与去抑制或 放松对定向过程的管制。关联的话务员分段 带着酒精。