Subject Collection

主题集

• 批准号: 8381783
• 负责人: SAMUEL KUPERMAN
• 金额: $ 53.35万
• 依托单位: SUNY DOWNSTATE MEDICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8381783
• 关键词: Admission activity; Adolescent; Age; Alcohol consumption; Alcohol dependence; Alcohol or Other Drugs use; Alzheimer' s Disease; Blood specimen; Characteristics; Child; Clinic; Collection; Consent; Craniocerebral Trauma; Dental; Drug usage; Exclusion; Exclusion Criteria; Family; Family member; Genetic Markers; Guidelines; HIV; Individual; Informed Consent; Inpatients; Interview; Life; Liver diseases; Mails; Medical; Methods; Outpatients; Parents; Patients; Recording of previous events; Records; Recruitment Activity; Relative (related person); Reporting; Site; Subjects Selections; Testing; Time; Universities; Work; Writing; drinking; genetic analysis; genetic pedigree; genetics of alcoholism; intravenous drug user; member; nervous system disorder; neurophysiology; proband; problem drinker; prospective; young adult

1. An Overview of Subject Selection and Characteristics The original COGA Guidelines for selection of probands, Identiflcation of appropriate relatives, and selection of controls and their families are outiined above. The proposed work will recruit no new families and will only draw upon members of the existing pedigrees. Appropriate members of COGA probands and comparison families will be invited to continue to participate In the prospective panel study, along with children who "age up" to the 12-year minimum age required for participation. Alcoholic probands had been originally ascertained from consecutive admissions to public and private inpatient and outpatient treatment facilities at each ofthe COGA participating sites. This Included individuals who fulfilled the COGA criteria for alcohol dependence, and who had multiple alcohol-dependent relatives living within 50 to 150 miles ofthe COGA Centers. Comparison families were selected using different methods across the subject collection sites, with approaches including random mailings to individuals affiliated with the respective university, people who are attending dental and medical clinic patients, and a random assessment through public records. Potential probands were excluded from the study if they had a mortal illness, were current IV drug users, reported an extensive history of IV drug use (31+ times), or were known to be infected with the HIV virus. These exclusion criteria are not applied to family members. In general, for all subjects medical or psychiatric conditions were the only general grounds for exclusion if it seemed probable that they might compromise a subject's ability to provide informed consent (e.g., advanced Alzheimer's disease) or hinder one's participation in the blood sampling or electrophysiological portions ofthe study (e.g., liver disease, neurological disease, head injuries, etc.). For the current ongoing study of adolescents and young adults, individuals younger than the age of majority (18 years) are assessed (including direct interviews, neurophysiological and electrophysiological testing, and blood samples) only following written consent is obtained from the parents and assent of the subject. The study of adolescents and young adults is essential to facilitate genetic analyses of characteristics related to the onset of alcohol and substance use and associated problems. These findings will facilitate our understanding of the potential importance of specific genetic markers and enhance our understanding of eariy drinking parameters.

1。主题选择和特征的概述 最初的COGA选择准则，确定适当的亲戚和 选择控制及其家人的选择在上面排除在外。拟议的工作将不招募任何新家庭， 只会利用现有的血统成员。 COGA概率的适当成员和 比较家庭将被邀请继续参加前瞻性小组研究，以及儿童 谁会“年龄”到参与所需的最低12年年龄。 最初从连续的招生到公共和私人的酒精概。 COGA参与地点的住院和门诊治疗设施。其中包括个人 谁满足了酒精依赖的COGA标准，并且有多个酒精依赖的亲戚 居住在COGA中心50至150英里以内。使用不同的方法选择了比较家族 在主题收集站点中 各自的大学，正在参加牙科和医疗诊所患者的人以及随机评估 通过公共记录。 如果他们患有致命疾病，则将潜在的证据排除在研究之外，目前是IV吸毒者， 报道了静脉注射药物使用的广泛史（31次以上），或已知感染了HIV病毒。 这些排除标准不适用于家庭成员。通常，对于所有受试者医学或精神病学 条件是唯一的排除理由，如果似乎可能会损害它们 受试者提供知情同意的能力（例如，高级阿尔茨海默氏病）或阻碍参与的能力 在研究的血液采样或电生理部分中（例如肝病，神经疾病， 头部受伤等）。 对于当前正在进行的青少年和年轻人的研究，年龄以下的个人 评估多数（18年）（包括直接访谈，神经生理和电生理学 测试和血液样本）仅在书面同意后得到父母的同意和同意 主题。对青少年和年轻人的研究对于促进特征的遗传分析至关重要 与酒精和药物使用以及相关问题有关。这些发现将有助于我们 了解特定遗传标记的潜在重要性并增强我们对耳语的理解 饮酒参数。