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Reward Valuation and Suicidal Behavior in High-Risk Adolescents

高危青少年的奖励评估和自杀行为

基本信息

批准号：
10655103
负责人：
AUTUMN J KUJAWA
金额：
$ 77.74万
依托单位：
VANDERBILT UNIVERSITY
依托单位国家：
美国
项目类别：
财政年份：
2023
资助国家：
美国
起止时间：
2023-04-07 至 2028-01-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10655103
关键词：
17 year old Acute Address Admission activity Adolescent Age Behavior Behavioral Buffers Cause of Death Clinical assessments Communication Complex Data Development Diagnostic Disclosure Economic Burden Electroencephalography Emotional Exhibits Feeling suicidal Frequencies Future Goals Health Hospitals Hour Individual Differences Interruption Intervention Interview Link Literature Longevity Measures Mental Depression Methods Modeling National Institute of Mental Health Pain Participant Pathway interactions Patient Self-Report Patients Pattern Positive Valence Predictive Factor Predisposition Process Prospective Studies Psychiatric therapeutic procedure Psychological reinforcement Psychopathology Public Health Recording of previous events Research Research Domain Criteria Research Priority Rewards Risk Risk Behaviors Risk Factors Sampling Social Environment Social support Stress Suicide Suicide attempt Suicide prevention Surveys System Techniques Telephone Testing Thinking Time Youth adolescent suicide behavior measurement behavioral outcome biomarker identification brain based cost effective direct application discounting follow-up high risk high-risk adolescents innovation insight neural neural circuit neuroimaging novel pleasure precision medicine preference prospective prospective test psychiatric symptom recruit reinforcer response reward processing social stressor suicidal adolescent suicidal behavior suicidal morbidity suicidal risk suicide model theories

项目摘要

PROJECT SUMMARY Suicide is a leading cause of death for adolescents worldwide, and rates have increased over the past decade. Yet, we lack reliable predictors of suicidal behavior (SB) due in part to a need to consider a broader range of risk processes and methods of assessment. There is a particularly critical and urgent need for research on objective, prospective predictors of SB to identify youth at greatest risk and elucidate novel targets for intervention. The goal of this study is to characterize alterations in RDoC’s Positive Valence Systems, particularly neural processes involve in reward valuation, in a large, high-risk sample of adolescents in acute psychiatric treatment for self-injurious thoughts and behaviors (SITBs) who will be followed for 6 months following discharge—a period of high risk for SB. Our preliminary data and theories of SB highlight a key role of reward valuation in that SB partly reflects a choice between immediate relief from emotional pain rather than waiting for potential future rewards that come from continuing to live through difficult times. Consistent with this, rigorous cross-sectional research has linked SB to greater discounting of the value of delayed monetary rewards, and our preliminary data indicate enhanced neural responsiveness to immediate relative to delayed rewards in youth with recent SB. Importantly, preferences for immediate rather than delayed reinforcers are known to increase in times of high stress, and acute interpersonal stress is associated with elevated risk for SB in adolescents, while social support tends to be protective. This multi-method, prospective study will test an innovative conceptual model of SB by which youth with enhanced neural reactivity to immediate reinforcers and blunted reactivity to delayed rewards are more likely to engage in SB, particularly in times of acute interpersonal stress, and social support buffers effects of reward valuation on SB. We will recruit a transdiagnostic sample of adolescents (ages 13-17 years; N=300) in acute psychiatric treatment for SITBs. Participants will complete clinical assessments and behavioral and neural measures of reward valuation in the hospital to capture a high-risk state and minimize participant burden. Following discharge, participants will complete a brief daily survey of interpersonal stress, social support, and SITBs for 90 days. Finally, participants will complete follow-up interviews of SITBs 6 months after discharge to test prospective predictors of SB. This study will characterize patterns of reward valuation associated with SB histories in high-risk youth (Aim 1), examine neural measures of reward valuation as prospective predictors of SB following hospital discharge (Aim 2), and examine the interplay between neural reward valuation and interpersonal factors in the proximal prediction of SB (Aim 3). This study directly addresses NIMH priorities and will be the first to examine neural predictors of future SB in a large, high-risk sample of youth, extending RDoC-informed research on suicide risk to the Positive Valence Systems domain. This research will lead to the identification of objective predictors of SB risk and the development of more personalized, targeted interventions to prevent SB and suicide deaths.

项目总结