ANIMAL RESOURCES

动物模型对于理解癌症的分子原因和评估潜在的 治疗方法。该设施的使命是最大限度地提高动物的科学效益 实验，同时保持对动物福利的重视。这两项努力都是 成功从动物福利的角度来看。动物资源已获得AAALAC认证， 1988年，最近一次更新于2009年3月完成。从科学角度来说，该设施对 癌症中心的成功，支持各种各样的研究，导致超过200 在过去的资助期内。动物资源占地12，800平方米。英尺的空间，近10，000的 属于集中式养殖设施，已扩大并升级为全通风 笼子里对于主动实验，将小鼠转移到隔壁建筑物中的设施（1，740平方米）。ft.）。 资源中心目前的运作量为9，400个铁笼的76%，可容纳480多个 转基因小鼠品系 服务包括：1]饲养2]繁殖群维护（每天0.64美元/笼的费率包括 饲养、育种、断奶、耳部切口、尾部取样）3]转基因/敲除小鼠设施，4]体内 成像和分析设施，和5]技术支持（例如，采血、注射、给药， 肿瘤测量、麻醉、手术、术后护理）。资源服务的业务费用为 主要以收费方式从设施使用者收回，包括资本设备、设备 维修和建设资金由研究所提供支持。目前的融资期已经看到 增加使用动物园资源来研究癌症相关现象。该设施提供了几个 研究肿瘤形成和转移的标准化模型，并将继续扩大这一努力。 在上一个供资期启动的体内成像和分析设施支持生物发光和 荧光成像（Xenogen IVIS 200）、超声成像（Visual Sonics Vevo 770）、沿着 血液学和血清分析。该资源储备了一组特征良好的标准和 琼脂糖酶标记的肿瘤细胞系，以扩大研究人员量化和表征肿瘤的能力 进展其他成像仪器，如活体显微镜和microPET，将在 评估未来收购。2008年，96%的资源用户是癌症中心成员， 来自所有四个项目的40名癌症中心研究人员利用了该资源。CCSG 124，455美元 第一年要求提供的支助占年度业务预算估计总额的4.6%。

Animal models are essential for understanding the molecular causes for cancers and assessing potential therapeutic approaches. The facility's mission is to maximize the scientific benefits of animal experimentation, while maintaining an emphasis on animal welfare. Both of these efforts have been successful. From the animal welfare standpoint. Animal Resources has been AAALAC accredited since 1988, with the most recent renewal completed in March 2009. Scientifically, the facility has been critical to the success of the Cancer Center, supporting a wide variety of studies, which resulted in over 200 publications in the past funding period. Animal Resources occupies 12,800 sq. ft. of space, almost 10,000 of which belong to the centralized breeding facility, which has been expanded and upgraded to all ventilated caging. For active experimentation, mice are transferred to a facility in the building next door (1,740 sq. ft.). The Resource currently operates at 76% of its current capacity of 9,400 cages, housing more than 480 genetically altered lines of mice. Services include: 1] husbandry 2] breeding colony maintenance (the $0.64/cage per diem rate includes husbandry, breeding, weaning, ear notching, tail sampling) 3] transgenic/knockout mouse facility, 4] in vivo imaging and analysis facility, and 5] technical support (e.g., blood collection, injections, drug administration, tumor measurements, anesthesia, surgeries, post-op care). Operating costs of Resource services are recovered largely on a charge-back basis from facility users, with capital equipment, equipment maintenance, and construction funds provided from Institute support. The current funding period has seen an increase in the use of vivarium resources to study cancer-related phenomena. The Facility offers several standardized models for studying tumor formation and metastasis, and will continue to expand this effort. The In Vivo imaging and Analysis Facility, initiated in the last funding period, supports bioluminescent and fluorescent imaging (Xenogen IVIS200), ultrasound imaging (Visual Sonics Vevo770), along with hematology and serum analysis. The Resource stocks a panel of well characterized standard and luciferase-labeled tumor cell lines, to expand investigators' ability to quantify and characterize tumor progression. Additional imaging instrumentation, such as intravital microscopy and microPET will be evaluated for future acquisition. In 2008, 96% of the Resource users were Cancer Center members, with a total of 40 Cancer Center investigators from all four Programs utilizing the Resource. $124,455 in CCSG support is requested in the first year, representing 4.6% of the total estimated annual operating budget.