ANIMAL RESOURCES

动物模型对于了解癌症的分子病因和评估潜在的癌症是必不可少的。 治疗方法。该设施的任务是使动物的科学利益最大化 实验，同时保持对动物福利的重视。这两项努力都是 成功。从动物福利的角度来看。动物资源已通过AAALAC认证 1988年，最近一次续期于2009年3月完成。从科学上讲，该设施对 癌症中心的成功，支持了各种研究，导致了200多项研究 在过去的资助期内出版的出版物。动物资源占地12,800平方米。英国《金融时报》太空中，几乎一万个 属于集中养殖设施，已扩建升级为全通风 关进笼子里。为了进行积极的实验，老鼠被转移到隔壁建筑内的设施(1740平方米。FT.)。 该资源目前的运营能力是目前9,400个网箱的76%，可容纳480多个网箱 基因改变的小鼠品系。 服务包括：1)畜牧业2]繁殖群体维护(每笼每天0.64美元的费率包括 饲养、饲养、断奶、割耳、尾巴取样)3)转基因/基因敲除小鼠设施，4]体内 成像和分析设施，以及5]技术支持(例如，采血、注射、给药、 肿瘤测量、麻醉、手术、术后护理)。资源服务的运营成本为 主要以按存储容量使用计费的方式从设施用户处回收，包括资本设备、设备 维护，以及由研究所支持提供的建设资金。目前的资助期已经看到 更多地使用资源来研究与癌症相关的现象。该设施提供了几个 研究肿瘤形成和转移的标准化模型，并将继续扩大这一努力。 在上一个资助期启动的体内成像和分析设施，支持生物发光和 荧光成像(Xenogen IVIS200)、超声成像(VisualSonics Vevo770)以及 血液学和血清分析。该资源储备了一组具有良好特色的标准和 荧光素酶标记的肿瘤细胞系，以扩大研究人员量化和表征肿瘤的能力 进步。其他成像仪器，如活体显微镜和微型PET将 为未来的收购进行评估。2008年，96%的资源用户是癌症中心成员，其中 来自所有四个项目的40名癌症中心研究人员利用该资源。CCSG中的124,455美元 第一年请求提供支助，占估计年度业务预算总额的4.6%。

Animal models are essential for understanding the molecular causes for cancers and assessing potential therapeutic approaches. The facility's mission is to maximize the scientific benefits of animal experimentation, while maintaining an emphasis on animal welfare. Both of these efforts have been successful. From the animal welfare standpoint. Animal Resources has been AAALAC accredited since 1988, with the most recent renewal completed in March 2009. Scientifically, the facility has been critical to the success of the Cancer Center, supporting a wide variety of studies, which resulted in over 200 publications in the past funding period. Animal Resources occupies 12,800 sq. ft. of space, almost 10,000 of which belong to the centralized breeding facility, which has been expanded and upgraded to all ventilated caging. For active experimentation, mice are transferred to a facility in the building next door (1,740 sq. ft.). The Resource currently operates at 76% of its current capacity of 9,400 cages, housing more than 480 genetically altered lines of mice. Services include: 1] husbandry 2] breeding colony maintenance (the $0.64/cage per diem rate includes husbandry, breeding, weaning, ear notching, tail sampling) 3] transgenic/knockout mouse facility, 4] in vivo imaging and analysis facility, and 5] technical support (e.g., blood collection, injections, drug administration, tumor measurements, anesthesia, surgeries, post-op care). Operating costs of Resource services are recovered largely on a charge-back basis from facility users, with capital equipment, equipment maintenance, and construction funds provided from Institute support. The current funding period has seen an increase in the use of vivarium resources to study cancer-related phenomena. The Facility offers several standardized models for studying tumor formation and metastasis, and will continue to expand this effort. The In Vivo imaging and Analysis Facility, initiated in the last funding period, supports bioluminescent and fluorescent imaging (Xenogen IVIS200), ultrasound imaging (Visual Sonics Vevo770), along with hematology and serum analysis. The Resource stocks a panel of well characterized standard and luciferase-labeled tumor cell lines, to expand investigators' ability to quantify and characterize tumor progression. Additional imaging instrumentation, such as intravital microscopy and microPET will be evaluated for future acquisition. In 2008, 96% of the Resource users were Cancer Center members, with a total of 40 Cancer Center investigators from all four Programs utilizing the Resource. $124,455 in CCSG support is requested in the first year, representing 4.6% of the total estimated annual operating budget.