Translational Research in GI Cancer

描述（由申请人提供）：为了利用密歇根大学丰富的智力和体力资源，降低胰腺癌和结直肠癌的发病率和死亡率，提出了一个名为“Gl癌症转化研究”的专业研究卓越项目（SPORE）。SPORE将提出这样的假设：通过风险识别、预防性干预、早期检测或改进侵袭性癌症的治疗，识别和发展干预措施，以解决增强细胞癌变或细胞转化表型的分子事件，从而降低与结直肠癌和胰腺癌相关的发病率和死亡率。这个综合转化研究项目包括四个主要项目，探索1)鱼油干预作为结直肠癌的化学预防措施；2)利用糖蛋白组学方法开发和验证用于胰腺癌和结直肠癌早期检测的生物标志物；3)靶向抑制Chk1作为减少胰腺癌放射损伤修复的机制；4)通过靶向抑制ATDC降低DNA损伤反应改善胰腺癌治疗。职业发展和发展研究项目补充了这些主要的转化项目，以确定结直肠癌和胰腺癌的新的风险评估、预防和治疗目标。所有孢子研究将由三个核心资源（行政管理，生物统计和信息学，以及生物样本）支持。孢子是密歇根大学综合癌症中心的一个完全集成的组成部分。SPORE也被整合到密歇根大学临床与健康研究所，这是医学院和健康科学校园的一个新的转化研究资源。SPORE整合了其他SPORE项目，并将国家SPORE项目与其他国家癌症研究资源（如早期检测研究网络和西南肿瘤小组）联系起来。这个Gl SPORE对其转化研究项目进行严格的科学审查，对基础和临床研究人员进行配对，利用不同科学家的专业知识，并利用灵活性为有前途的新研究方法提供资金。我们的多学科研究小组的相互作用使得密歇根大学综合癌症中心的Gl孢子大于其单个部分的总和。

DESCRIPTION (provided by applicant): A Specialized Program of Research Excellence (SPORE) entitled "Translational Research in Gl Cancer" is proposed to tap the vast intellectual and physical resources of the University of Michigan to decrease the morbidity and mortality from pancreatic and colorectal cancers. The SPORE will address the hypothesis that identifying and developing interventions to address molecular events that enhance cellular carcinogenesis or cellular transformed phenotype will reduce the morbidity and mortality associated with colorectal and pancreatic cancers through risk identification, preventive interventions, early detection, or improved treatment of invasive cancer. This integrated translational research program consists of four major projects that explore 1) fish oil intervention as a chemopreventive for colorectal cancer; 2) development and validation of biomarkers for the early detection of pancreatic and colorectal cancer using glycoproteomics methods; 3) targeted inhibition of Chk1 as a mechanism to reduce repair of radiation induced damage to pancreatic cancer; and 4) improved treatment of pancreatic cancer through targeted inhibition of ATDC to reduce DNA damage response. These major translational projects are complemented by Career Development and Developmental Research Programs that identify new risk assessment, preventive and treatment targets for colorectal and pancreatic cancers. All SPORE studies will be supported by three Core Resources (Administrative, Biostatistics and Informatics, and Biosample). The SPORE is a fully integrated component of the University of Michigan Comprehensive Cancer Center. The SPORE is also integrated into the University of Michigan's Institute for Clinical and Health Research, a new translational research resource for the Medical School and Health Sciences Campus. The SPORE integrates other SPORE programs and links the National SPORE program to other national cancer research resources such as the Early Detection Research Network and the Southwest Oncology Group. This Gl SPORE places premiums on rigorous scientific review of its translational research programs, pairing of basic and clinical investigators, drawing on the expertise of diverse scientists, and utilizing flexibility to fund promising new research approaches. The interaction of our multidisciplinary group of investigators makes the Gl SPORE at the University of Michigan Comprehensive Cancer Center greater than the sum of its individual parts.