Translating Cancer Prevention Research in the Developing World

将癌症预防研究转化为发展中国家

• 批准号: 8130350
• 负责人: Dean E. Brenner
• 金额: $ 2.5万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-02-01 至 2012-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8130350
• 关键词: Address; Adjuvant; Basic Science; Biological Markers; Biomedical Research; Breast; Cancer Biology; Cancer Center; Cancer Control; Cervix Uteri; Chemopreventive Agent; Clinical; Clinical Research; Collaborations; Colon Carcinoma; Colonoscopy; Communication; Country; Data; Developed Countries; Developing Countries; Development; Discipline; Early Diagnosis; Educational workshop; Environment; Epidemiologist; Europe; Fecal occult blood; Flexible fiberoptic sigmoidoscopy; Focus Groups; Future; Genetic; Genomics; Goals; Grant; Group Meetings; Hormonal; Incidence; India; Individual; Industry; International; Intervention; Israel; Laboratory Study; Lead; Link; Location; Malignant Neoplasms; Mammography; Medical Research; Modeling; Molecular; Molecular Carcinogenesis; Morbidity - disease rate; National Cancer Institute; Organ; Paper; Peer Review; Policies; Population; Population Study; Populations at Risk; Prevention; Prevention Research; Prevention strategy; Preventive Intervention; Proteomics; Publications; Research; Research Infrastructure; Research Personnel; Resources; Risk Assessment; Risk Reduction; Rural; Rural Population; Sampling; Scientist; Screening for cancer; Screening procedure; Site; Social Interaction; Structure; Technology; Testing; Time; Training; Translating; Translational Research; Translational Research Working Group; Translations; Trust; United States; Work; base; cancer prevention; cancer risk; cancer therapy; clinical application; cost; cost effective; cytotoxic; design; experience; gene environment interaction; global health; improved; lectures; malignant breast neoplasm; meetings; metabolomics; mortality; population based; skills; symposium; technology validation; tool; willingness

DESCRIPTION (provided by applicant): Meeting grant support is requested for a scientific workshop entitled, "Translating Cancer Prevention Research in Developing Countries". This workshop will be held at the Crowne Plaza Hotel and Mazumdar Shaw Cancer Center in Bangalore, India, on February 13-17, 2011. The organizing committee for this workshop consists of Drs. Dean Brenner (USA), Madhuri Kakarala (USA), Kishore Chaudhry (India) and M. Abraham Kuriakose (India). The objectives of this conference are: 1: To identify overlapping mutually beneficial translational cancer prevention research questions that address cancer prevention and control priorities in India and the United States through: a. Comparing and contrasting cancer prevention research scientific strategies in various countries. b. Identifying the resources available and necessary infrastructure to support collaborative translational cancer prevention research among developing countries using India as an example and developed countries using the United States as an example. 2: To review and compare population based gene-environment interactions in Indian populations with those of other countries. 3: To review preventive strategies in organ site specific high incidence and mortality cancers common to India, Europe and the United States (airway, breast, cervix) that: a. Embrace and respect local culture and traditions and provide leads for cancer risk reduction strategies. b. Have potential to deploy to impoverished rural populations at low cost with minimal technological complexity. c. Will lead to cancer incidence and mortality reductions in developing and developed countries. Conferees are invited based upon their diversity in scientific discipline, interactive and collaborative experience and track-record, and perceived willingness to alter preconceptions in order to accommodate new information and reformulate future research plans. The Conference is intense and modeled after the Gordon Conferences. It requires conferees to remain segregated as a group for four days, working closely together. Meals and free time are structured to enhance the opportunities of conferees to interact informally. The Conference features panels consisting of 10 minute lectures, frequent discussion periods, multiple 60 minute panel discussions, lunch and dinner periods with focused group meetings, and an end of conference summary document from each of 7 panel discussions to create the need for closure and focus. The summary documents and speaker papers will be submitted for publication in Cancer Prevention and Cancer Biomarkers after appropriate peer review. By intensively interacting, conferees will become familiar with each other, will understand the strengths and weaknesses of the diverse disciplines represented at the meeting, and will recognize and establish cross disciplinary interactions to create necessary scientific critical masses to advance the field. PUBLIC HEALTH RELEVANCE: This workshop addresses cancer prevention on a global health scale. It addresses the key issues of translation of cancer prevention research to population and clinical application in a large, diverse developing country and its potential benefit world-wide. The workshop is designed to maximize the opportunities for collaboration, creating an environment in which scientists may exchange concepts and samples, thus permitting comparison of data from diverse genetic pools. Such infrastructure is crucial to the future development and deployment of cost effective, cancer early detection and screening technologies aimed at reducing mortality on a global scale, particularly in large population, cost constrained environments.

描述（由申请人提供）：会议补助金支持要求为一个科学研讨会，题为“翻译发展中国家的癌症预防研究”。该研讨会将于2011年2月13日至17日在印度班加罗尔的皇冠假日酒店和Mazumdar Shaw癌症中心举行。这次研讨会的组织委员会由Dean Brenner博士（美国）、Madhuri Kakarala（美国）、Kishore Chaudhry（印度）和M. Abraham Kuriakose（印度）。这次会议的目标是： 一曰：确定重叠的互惠转化癌症预防研究问题，通过以下方式解决印度和美国的癌症预防和控制优先事项： a.比较和对比不同国家的癌症预防研究科学策略。 B.确定可用的资源和必要的基础设施，以支持以印度为例的发展中国家和以美国为例的发达国家之间的合作转化癌症预防研究。 2：审查和比较印度人口与其他国家人口的基因-环境相互作用。 第三章：审查印度、欧洲和美国常见的器官部位特异性高发病率和死亡率癌症（气道、乳腺、宫颈）的预防策略： a.拥抱和尊重当地文化和传统，为降低癌症风险战略提供指导。 B.有可能以低成本和最低的技术复杂性部署到贫困的农村人口。 C.将导致发展中国家和发达国家的癌症发病率和死亡率下降。 邀请与会者的依据是他们在科学学科、互动和协作经验和跟踪记录方面的多样性，以及改变先入为主的观念以适应新信息和重新制定未来研究计划的意愿。会议是紧张的，仿照戈登会议。它要求与会者作为一个小组保持隔离四天，密切合作。安排膳食和空闲时间是为了增加与会者进行非正式互动的机会。会议的特点包括10分钟的讲座，频繁的讨论时间，多个60分钟的小组讨论，午餐和晚餐时间与重点小组会议，并从7个小组讨论的每一个会议总结文件结束，以创建关闭和重点的需要。摘要文件和演讲者论文将在适当的同行评审后提交发表在《癌症预防和癌症生物标志物》上。通过深入的互动，与会者将相互熟悉，了解会议上所代表的不同学科的优势和劣势，并将认识和建立跨学科的互动，以创造必要的科学临界群众来推进该领域。 公共卫生相关性：本研讨会讨论全球健康范围内的癌症预防。它解决了癌症预防研究转化为人口和临床应用在一个大的，多样化的发展中国家及其潜在的利益全世界的关键问题。讲习班旨在最大限度地扩大合作机会，创造一个科学家可以交流概念和样本的环境，从而能够比较来自不同基因库的数据。这种基础设施对于未来开发和部署具有成本效益的癌症早期检测和筛查技术至关重要，这些技术旨在降低全球范围内的死亡率，特别是在人口众多、成本有限的环境中。