Aging-Related Biodemography of Life Course Physiology and Environmental Modifiers

生命历程生理学和环境调节剂与衰老相关的生物人口学

• 批准号: 8223264
• 负责人: Christopher Seplaki
• 金额: $ 12.36万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-03-15 至 2014-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8223264
• 关键词: Address; Affect; Age Distribution; Aging; Aging-Related Process; American; Award; Biological; Biological Markers; Biological Markers; Birth; Clinical; Communities; Data; Development; Disease; Dose; Elderly; Environment; Environmental Risk Factor; Epidemiology; Exposure to; Goals; Health; Impairment; Individual; Laboratories; Life Cycle Stages; Life Expectancy; Link; Minority Groups; Morbidity - disease rate; Outcome; Pathway interactions; Pattern; Persons; Phase; Physical environment; Physiological; Physiology; Population; Population Research; Principal Investigator; Race; Regulation; Relative (related person); Research Personnel; Risk; Shapes; Socioeconomic Status; Staging; Statistical Methods; Stress; Subgroup; System; Testing; Training; Underrepresented Minority; Variant; Work; adverse outcome; age related; base; biodemography; body system; career; caucasian American; cohort; disability; experience; frailty; improved; indium arsenide; low socioeconomic status; minimally invasive; mortality; population based; population health; programs; resilience; sample collection; sex; social; stressor; trend

DESCRIPTION (provided by applicant): New integrative biodemographic and gerontological frameworks, a better etiologic understanding of both disease and geriatric conditions, and technological advances in minimally-invasive specimen collection are resulting in the incorporation of increasingly broad arrays of biological markers into population research. This career award will draw on these advances to examine impairment in the regulation of interacting physiologic (e.g., organ) systems. Such impairment is theorized to reflect decreased resilience to social and physical challenges. We hypothesize that 1) reaching a critical mass of impaired regulation among physiologic systems accelerates the risk of frailty, disability, and mortality; 2) that impaired regulation among physiologic systems, as well as frailty, disability and mortality, tend to emerge earlier in the life course in persons who are chronically subjected to high levels of environmental challenge; and 3) that observed increases in life expectancy represent secular trends in improved health and later onset of impaired regulation among physiologic systems and outcomes in more recent birth cohorts, relative to older birth cohorts, and that this delay will be less in those with greater exposure to challenges, lower socioeconomic status, and Americans from underrepresented minority groups compared to white Americans. I will use data from five major population-based studies and achieve my goal in three steps that comprise my aims. The steps are to determine: when and how impairment in regulation emerges, how it is associated with potential sequelae, and variations across vulnerable subgroups (Aim 1); whether impaired physiologic regulation is affected by challenges in the environment (Aim 2); and how individual and environmental factors jointly shape the health and function of older adults in the U.S., both individually and at the population level (Aim 3). During the award period I will obtain specialized training in physical environment challenges facing older adults, advanced statistical methods, and biological, clinical, and laboratory content. This training will enable me to continue my development into an independent researcher focused on understanding the biological pathways that link social and physical challenges to health among community-dwelling older adults, and the significance of these pathways for changes in population health.

描述（由申请人提供）：新的综合生物人口统计学和老年学框架，对疾病和老年状况的更好病因学理解，以及微创标本采集的技术进步，导致将越来越广泛的生物标志物纳入人口研究。这个职业奖将利用这些进展来检查相互作用的生理调节障碍（例如，器官）系统。理论上，这种损害反映了对社会和身体挑战的适应能力下降。我们假设：1）生理系统调节受损达到临界质量会加速虚弱、残疾和死亡的风险; 2）生理系统调节受损以及虚弱、残疾和死亡往往在长期受到高水平环境挑战的人的生命过程中出现得更早;和3）观察到的预期寿命的增加代表了长期趋势，即相对于年龄较大的出生队列，最近出生的队列的健康状况得到改善，生理系统和结果中的调节受损发生较晚，并且这种延迟在那些面临更多挑战的人中会更少，较低的社会经济地位，以及与白色美国人相比，来自代表性不足的少数群体的美国人。我将使用来自五项主要人群研究的数据，并通过三个步骤实现我的目标。步骤是确定：调节障碍何时以及如何出现，它如何与潜在的后遗症相关，以及脆弱亚群的变化（目标1）;生理调节障碍是否受到环境挑战的影响（目标2）;以及个人和环境因素如何共同塑造美国老年人的健康和功能，在个人和人口一级（目标3）。在获奖期间，我将获得老年人面临的物理环境挑战，先进的统计方法，生物，临床和实验室内容的专业培训。这项培训将使我能够继续发展成为一名独立的研究人员，专注于了解将社会和身体挑战与社区居住的老年人健康联系起来的生物学途径，以及这些途径对人口健康变化的重要性。