Aging-Related Biodemography of Life Course Physiology and Environmental Modifiers

生命历程生理学和环境调节剂与衰老相关的生物人口学

• 批准号: 8023157
• 负责人: Christopher Seplaki
• 金额: $ 12.07万
• 依托单位: UNIVERSITY OF ROCHESTER
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-03-15 至 2014-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8023157
• 关键词: Address; Affect; Age Distribution; Aging; Aging-Related Process; American; Award; Biological; Biological Markers; Biological Markers; Birth; Clinical; Communities; Data; Development; Disease; Dose; Elderly; Environment; Environmental Risk Factor; Epidemiology; Exposure to; Goals; Health; Impairment; Individual; Laboratories; Life Cycle Stages; Life Expectancy; Link; Minority Groups; Morbidity - disease rate; Outcome; Pathway interactions; Pattern; Persons; Phase; Physical environment; Physiological; Physiology; Population; Population Research; Principal Investigator; Race; Regulation; Relative (related person); Research; Research Personnel; Risk; Shapes; Socioeconomic Status; Staging; Statistical Methods; Stress; Subgroup; System; Testing; Training; Underrepresented Minority; Variant; Work; adverse outcome; age related; base; biodemography; body system; career; caucasian American; cohort; disability; experience; frailty; improved; indium arsenide; low socioeconomic status; minimally invasive; mortality; population based; population health; programs; resilience; sample collection; sex; social; stressor; trend

DESCRIPTION (provided by applicant): New integrative biodemographic and gerontological frameworks, a better etiologic understanding of both disease and geriatric conditions, and technological advances in minimally-invasive specimen collection are resulting in the incorporation of increasingly broad arrays of biological markers into population research. This career award will draw on these advances to examine impairment in the regulation of interacting physiologic (e.g., organ) systems. Such impairment is theorized to reflect decreased resilience to social and physical challenges. We hypothesize that 1) reaching a critical mass of impaired regulation among physiologic systems accelerates the risk of frailty, disability, and mortality; 2) that impaired regulation among physiologic systems, as well as frailty, disability and mortality, tend to emerge earlier in the life course in persons who are chronically subjected to high levels of environmental challenge; and 3) that observed increases in life expectancy represent secular trends in improved health and later onset of impaired regulation among physiologic systems and outcomes in more recent birth cohorts, relative to older birth cohorts, and that this delay will be less in those with greater exposure to challenges, lower socioeconomic status, and Americans from underrepresented minority groups compared to white Americans. I will use data from five major population-based studies and achieve my goal in three steps that comprise my aims. The steps are to determine: when and how impairment in regulation emerges, how it is associated with potential sequelae, and variations across vulnerable subgroups (Aim 1); whether impaired physiologic regulation is affected by challenges in the environment (Aim 2); and how individual and environmental factors jointly shape the health and function of older adults in the U.S., both individually and at the population level (Aim 3). During the award period I will obtain specialized training in physical environment challenges facing older adults, advanced statistical methods, and biological, clinical, and laboratory content. This training will enable me to continue my development into an independent researcher focused on understanding the biological pathways that link social and physical challenges to health among community-dwelling older adults, and the significance of these pathways for changes in population health.

描述（由申请人提供）：新的综合生物人口统计学和老年学框架、对疾病和老年病的病因学更好的理解以及微创标本采集的技术进步正在导致越来越广泛的生物标记物纳入人口研究。该职业奖将利用这些进展来检查相互作用的生理（例如器官）系统的调节损伤。从理论上讲，这种损害反映了对社会和身体挑战的适应能力下降。我们假设：1）生理系统调节受损达到临界量会加速虚弱、残疾和死亡的风险； 2) 对于长期遭受高水平环境挑战的人来说，生理系统调节受损以及虚弱、残疾和死亡往往会在生命历程的早期出现； 3) 观察到的预期寿命的增加代表了健康状况改善的长期趋势，以及较晚出生队列中生理系统和结果的调节受损较晚发生的趋势，相对于较年长的出生队列，并且与美国白人相比，在那些面临更多挑战、较低社会经济地位和来自代表性不足的少数群体的美国人中，这种延迟会更小。我将使用五项主要的基于人群的研究的数据，并通过构成我的目标的三个步骤来实现我的目标。这些步骤是确定：监管损害何时以及如何出现、它与潜在后遗症有何关联，以及弱势群体之间的差异（目标 1）；受损的生理调节是否受到环境挑战的影响（目标 2）；以及个人和环境因素如何共同影响美国老年人的健康和功能，无论是个人水平还是人口水平（目标 3）。在获奖期间，我将获得有关老年人面临的物理环境挑战、先进统计方法以及生物学、临床和实验室内容的专门培训。这项培训将使我能够继续发展成为一名独立研究员，专注于了解将社区老年人的社会和身体挑战与健康联系起来的生物途径，以及这些途径对人口健康变化的重要性。