Assessment of Cholinergic and Cognitive Function Using Pharmacologic ASL-Perfusio

使用药理学 ASL-Perfusio 评估胆碱能和认知功能

• 批准号: 8313985
• 负责人: TAMARA G FONG
• 金额: $ 12.61万
• 依托单位: HEBREW REHABILITATION CENTER FOR AGED
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-30 至 2014-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8313985
• 关键词: Acetylcholine; Advisory Committees; Affect; Aging; American; Anatomy; Arousal; Attention; Basic Science; Behavioral; Blood; Blood Circulation; Blood flow; Cerebral cortex; Cerebrovascular Circulation; Cerebrum; Cholinergic Agents; Cholinergic Agonists; Cholinergic Antagonists; Cholinesterase Inhibitors; Chronic; Clinical; Clinical Research; Cognition; Cognitive; Complement; Contrast Media; Crossover Design; Data; Delirium; Dementia; Development; Disease; Dose; Double-Blind Method; Elderly; Electromagnetics; Environment; Ethics; Experimental Designs; Fostering; Functional Imaging; Functional Magnetic Resonance Imaging; Functional disorder; Global Change; Health; Image; Impairment; K-Series Research Career Programs; Lead; Lewy Body Disease; Magnetic Resonance Imaging; Measurement; Measures; Mecamylamine; Mediating; Memory; Mentors; Methods; Muscarinic Acetylcholine Receptor; Muscarinic Antagonists; Muscarinics; National Institute of Neurological Disorders and Stroke; National Research Service Awards; Neurology; Neurons; Neuropharmacology; Neurotransmitters; Nicotinic Antagonists; Nicotinic Receptors; Parietal; Patients; Performance; Perfusion; Pharmaceutical Preparations; Pharmacotherapy; Physiology; Pilot Projects; Placebo Control; Play; Process; Property; Psyche structure; Quality of life; Radioactivity; Reaction Time; Regulation; Research; Research Design; Research Personnel; Research Project Grants; Resolution; Role; Scopolamine; Severities; Spin Labels; Study Section; System; Techniques; Testing; Tracer; Training; Water; age effect; age related; career development; cholinergic; cognitive function; donepezil; effective therapy; experience; experimental analysis; flexibility; health care quality; improved; in vivo; innovation; interest; neuroimaging; normal aging; patient oriented; programs; response; statistics; treatment strategy

DESCRIPTION (provided by applicant): This is an application for a Mentored Patient-Oriented Career Development Award (K23) entitled "Assessment of Cholinergic and Cognitive Function Using Pharmacologic ASL-perfusion MRI". Project Summary: This research project will investigate the value of combined pharmacologic manipulation and arterial spin-labeled perfusion MRI (pharmacologic ASL-pMRI) as an in vivo probe of cholinergic function. Methods to investigate cholinergic function in vivo are needed to better understand the role of acetylcholine in the physiology of the cerebral cortex, and in cognitive processes in health and in disease states. In this study, pharmacologic ASL-pMRI will be used to characterize the normal cerebral perfusion response to cholinergic manipulation in young healthy subjects. Cognitive measures will also be obtained and correlated with cerebral perfusion changes. Pharmacologic ASL-pMRI and cognitive testing will then be used to study how the cholinergic response is altered with normal aging and in delirium. The candidate's research interest is the application of pharmacologic neuroimaging to the study of cholinergic function in aging and age-related disease. The candidate's prior training includes basic science research in neuropharmacology, clinical training in behavioral neurology, and initial experience in functional imaging and clinical research under a NINDS-sponsored National Research Service Award. This proposed study will provide the candidate with more advanced training in the methods, applications, experimental design and analysis of functional MRI research, and will foster the candidate's development into an independent investigator with unique expertise in pharmacologic MRI. Didactic coursework in study design, statistics, ethics, and functional imaging will complement the research project. The research environment includes outstanding facilities for MRI and clinical research, and mentoring from a multi-disciplinary advisory committee. Relevance: The strengths of this application include the innovative use of pharmacologic ASL-pMRI in the research project, the expertise of the advisory committee, and the career development potential of the candidate. The proposed research project will elucidate the role of the cholinergic system in the common age-related neuropathologic conditions of dementia and delirium. This will in turn lead to new and more effective treatment strategies for these conditions, and help to improve health care and quality of life for the growing ranks of older Americans.

描述（由申请人提供）：这是一份申请指导患者导向职业发展奖（K23）的申请，题为“使用药理学asl灌注MRI评估胆碱能和认知功能”。项目概述：本课题将探讨联合药理学操作和动脉自旋标记灌注MRI （pharmacologic ASL-pMRI）作为体内胆碱能功能探针的价值。为了更好地了解乙酰胆碱在健康和疾病状态下的大脑皮层生理和认知过程中的作用，需要在体内研究胆碱能功能的方法。在这项研究中，药理学ASL-pMRI将用于表征年轻健康受试者对胆碱能操作的正常脑灌注反应。认知测量也将得到，并与脑灌注变化相关。药理学ASL-pMRI和认知测试将用于研究胆碱能反应如何随正常衰老和谵妄而改变。该候选人的研究兴趣是药理学神经影像学在衰老和年龄相关疾病中胆碱能功能研究中的应用。候选人之前的训练包括神经药理学的基础科学研究，行为神经学的临床训练，以及在ninds资助的国家研究服务奖下的功能成像和临床研究的初步经验。本研究将为候选人在功能MRI研究的方法、应用、实验设计和分析方面提供更高级的培训，并将培养候选人成为具有独特药理MRI专业知识的独立研究者。研究设计、统计学、伦理学和功能成像方面的教学课程将作为研究项目的补充。研究环境包括优秀的核磁共振和临床研究设施，以及多学科咨询委员会的指导。相关性：该申请的优势包括在研究项目中创新性地使用药理学ASL-pMRI，咨询委员会的专业知识，以及候选人的职业发展潜力。拟议的研究项目将阐明胆碱能系统在痴呆和谵妄等常见年龄相关神经病理条件中的作用。这将导致针对这些疾病的新的和更有效的治疗策略，并有助于改善日益增长的美国老年人的医疗保健和生活质量。