Assessment of Cholinergic and Cognitive Function Using Pharmacologic ASL-Perfusio

使用药理学 ASL-Perfusio 评估胆碱能和认知功能

• 批准号: 7689332
• 负责人: TAMARA G FONG
• 金额: $ 12.61万
• 依托单位: HEBREW REHABILITATION CENTER FOR AGED
• 依托单位国家: 美国
• 财政年份: 2008
• 资助国家: 美国
• 起止时间: 2008-09-30 至 2013-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7689332
• 关键词: Acetylcholine; Advisory Committees; Affect; Aging; Agonist; American; Anatomy; Arousal; Attention; Basic Science; Behavioral; Blood; Blood Circulation; Blood flow; Cerebral cortex; Cerebrovascular Circulation; Cerebrum; Cholinergic Agents; Cholinergic Antagonists; Cholinesterase Inhibitors; Chronic; Clinical; Clinical Research; Cognition; Cognitive; Complement; Contrast Media; Crossover Design; Data; Delirium; Dementia; Development; Disease; Dose; Double-Blind Method; Elderly; Electromagnetics; Environment; Ethics; Experimental Designs; Fostering; Functional Imaging; Functional Magnetic Resonance Imaging; Functional disorder; Global Change; Health; Image; Impairment; K-Series Research Career Programs; Lead; Lewy Body Disease; Magnetic Resonance Imaging; Measurement; Measures; Mecamylamine; Mediating; Memory; Mentors; Methods; Muscarinic Acetylcholine Receptor; Muscarinic Antagonists; Muscarinics; National Research Service Awards; Neurology; Neurons; Neuropharmacology; Neurotransmitters; Nicotinic Antagonists; Parietal; Patients; Performance; Perfusion; Pharmaceutical Preparations; Pharmacotherapy; Physiology; Pilot Projects; Placebo Control; Play; Process; Property; Psyche structure; Quality of life; Radioactivity; Reaction Time; Regulation; Research; Research Design; Research Personnel; Research Project Grants; Resolution; Role; Scopolamine; Severities; Spin Labels; Study Section; System; Techniques; Testing; Tracer; Training; Water; age effect; age related; career development; cholinergic; cognitive function; donepezil; effective therapy; experience; flexibility; health care quality; improved; in vivo; innovation; interest; neuroimaging; normal aging; patient oriented; programs; response; statistics; treatment strategy

DESCRIPTION (provided by applicant): This is an application for a Mentored Patient-Oriented Career Development Award (K23) entitled "Assessment of Cholinergic and Cognitive Function Using Pharmacologic ASL-perfusion MRI". Project Summary: This research project will investigate the value of combined pharmacologic manipulation and arterial spin-labeled perfusion MRI (pharmacologic ASL-pMRI) as an in vivo probe of cholinergic function. Methods to investigate cholinergic function in vivo are needed to better understand the role of acetylcholine in the physiology of the cerebral cortex, and in cognitive processes in health and in disease states. In this study, pharmacologic ASL-pMRI will be used to characterize the normal cerebral perfusion response to cholinergic manipulation in young healthy subjects. Cognitive measures will also be obtained and correlated with cerebral perfusion changes. Pharmacologic ASL-pMRI and cognitive testing will then be used to study how the cholinergic response is altered with normal aging and in delirium. The candidate's research interest is the application of pharmacologic neuroimaging to the study of cholinergic function in aging and age-related disease. The candidate's prior training includes basic science research in neuropharmacology, clinical training in behavioral neurology, and initial experience in functional imaging and clinical research under a NINDS-sponsored National Research Service Award. This proposed study will provide the candidate with more advanced training in the methods, applications, experimental design and analysis of functional MRI research, and will foster the candidate's development into an independent investigator with unique expertise in pharmacologic MRI. Didactic coursework in study design, statistics, ethics, and functional imaging will complement the research project. The research environment includes outstanding facilities for MRI and clinical research, and mentoring from a multi-disciplinary advisory committee. Relevance: The strengths of this application include the innovative use of pharmacologic ASL-pMRI in the research project, the expertise of the advisory committee, and the career development potential of the candidate. The proposed research project will elucidate the role of the cholinergic system in the common age-related neuropathologic conditions of dementia and delirium. This will in turn lead to new and more effective treatment strategies for these conditions, and help to improve health care and quality of life for the growing ranks of older Americans.

描述(由申请者提供)：这是一份以患者为导向的职业发展指导奖(K23)的申请书，标题为“使用药理学ASL-灌注MRI评估胆碱能和认知功能”。项目概述：本研究项目将探讨联合药理学操作和动脉自旋标记灌注MRI(药理学ASL-pMRI)作为体内胆碱能功能探针的价值。为了更好地了解乙酰胆碱在大脑皮层生理以及在健康和疾病状态下的认知过程中的作用，需要研究体内胆碱能功能的方法。在这项研究中，药理学ASL-pMRI将被用来表征年轻健康受试者对胆碱能操作的正常脑血流灌注反应。还将获得认知测量，并将其与脑血流灌注变化相关联。然后将使用药理学ASL-pMRI和认知测试来研究正常衰老和精神错乱时胆碱能反应是如何改变的。应聘者的研究兴趣是将药物神经成像应用于衰老和老年相关疾病中胆碱能功能的研究。候选人之前的培训包括神经药理学的基础科学研究，行为神经学的临床培训，以及NINDS赞助的国家研究服务奖下的功能成像和临床研究的初步经验。这项拟议的研究将在功能磁共振研究的方法、应用、实验设计和分析方面为候选人提供更高级的培训，并将促进候选人发展成为具有独特药理学MRI专业知识的独立研究员。研究设计、统计学、伦理学和功能成像方面的教学课程将补充研究项目。研究环境包括核磁共振和临床研究的卓越设施，以及来自多学科咨询委员会的指导。相关性：这项申请的优势包括在研究项目中创新性地使用药理学ASL-pMRI、咨询委员会的专业知识以及候选人的职业发展潜力。这项拟议的研究项目将阐明胆碱能系统在痴呆和精神错乱等常见的与年龄相关的神经病理条件中的作用。这将反过来导致针对这些疾病的新的、更有效的治疗策略，并有助于改善日益增长的美国老年人的医疗保健和生活质量。