National Cell Respository for Alzheimer's Disease (NCRAD) (U24)

项目主任/首席调查员(最后、第一、中间)：Foroud，Tatiana，M. 项目SUMIVIARY(请参阅说明)： 阿尔茨海默病国家细胞库(NCRAD)在国家研究所中发挥着关键作用 关于Aging(NIA)识别阿尔茨海默病(AD)高危人群并开发改进的治疗方法的努力 为了延迟或预防疾病的发生，NCRAD是作为与NIA的合作协议而建立的，以 作为NIA资助的所有痴呆症研究的主要样本共享来源。在…的建议下 NIA和细胞库咨询委员会，NCRAD的使命是消除阻碍 了解痴呆病因的研究进展。为了实现这一目标，NCRAD有两个主要方面 功能：样品银行和样品分发。 NCRAD作为中央存储库，使用unifomn存储来自NIA资助的正在进行的研究的样本 具有广泛质量措施的协议。储存的样本类型已经扩大到包括DNA， 细胞系、血浆、血清、脑组织和RNA。NCRAD与国家阿尔茨海默病协会密切合作 协调中心(NACC)，NIA的另一个核心设施，用作所有 阿尔茨海默病中心(ADC)。NCRAD和NACC共同充当 阿尔茨海默病遗传学联合会(ADGC)，协调从29个ADC收集样本。 NCRAD还广泛地将样本分发给调查人员进行自己的分析以及中央 核心，其中APOE基因分型，全基因组SNP阵列，现在是整个基因组和整个外显子组 进行测序研究。我们建议通过以下具体措施扩大我们的成功努力 目标； 1.为所有由NIA资助的痴呆症研究提供最先进的中央生物谱系信息库 包括DNA、细胞系、血浆、血清、 RNA和脑组织。 2.通过向所有有资格的调查人员分发数据和生物样本，促进和促进样本共享 用于他们的研究研究。 相关性(请参阅说明)： 有许多障碍阻碍了研究人员成功地研究 阿尔茨海默病和相关痴呆症。这些功能包括共享样本的能力、访问大型 高质量的样本数量和研究成果的有效共享。NCRAD在以下建议下 NIA和CBAC将解除这些禁令，并促进痴呆症研究人员之间的样本和数据共享。

Program Director/Principal Investigator (Last, First, Middle): ForOUd, Tatiana, M. PROJECT SUMIVIARY (See instructions): The National Cell Repository for Alzheimer's Disease (NCRAD) plays a key role in the National Institute on Aging's (NIA) efforts to identify those at risk for Alzheimer disease (AD) and develop improved treatments to delay or prevent disease onset NCRAD was established as a cooperative agreement with the NIA to serve as the primary source of sample sharing for all NIA-funded dementia studies. Under the advisement of NIA and the Cell Bank Advisory Committee, it is the mission of NCRAD to remove critical bamers hindering reseach progress to understand the etiology of dementia. To achieve this goal, NCRAD has two primary functions: sample banking and sample distribution. NCRAD serves as a central repository banking samples from ongoing NIA funded studies using unifomn protocols with extensive quality measures. The type of samples being banked has expanded to include DNA, cell lines, plasma, serum, brain tissue and RNA. NCRAD works closely with the National Alzheimer Coordinating Center (NACC), another NIA core facility that serves as the data coordinating center for all the Alzheimer Disease Centers (ADCs). Together, NCRAD and NACC serve as key resources within the Alzheimer Disease Genetics Consortium (ADGC), coordinating the collection of samples from the 29 ADCs. NCRAD also widely distributes samples both to investigators for their own analyses as well as to central cores, where APOE genotyping, genomewide SNP arrays, and now whole genome and whole exome sequencing studies are performed. We propose to expand our successful efforts with the following specific aims; 1. To provide a state-of-the-art central biospecimen repository for all NIA-funded dementia studies that includes detailed standard operating procedures for the secure banking of DNA, cell lines, plasma, serum, RNA, and brain tissue. 2. To facilitate and foster sample sharing by distributing data and biospedmens to all qualified investigators for use in their research studies. RELEVANCE (See instructions): There are a number of barriers that hamper the ability of researchers to perform successful studies of Alzheimer disease and related dementias. These include the ability to share samples, access to large numbers of high quality samples and effective sharing of research results. NCRAD under the advisement of NIA and CBAC will lift these ban-iers and faciliate sample and data sharing among dementia researchers.