National Cell Respository for Alzheimer's Disease (NCRAD) (U24)

国家阿尔茨海默病细胞存储库 (NCRAD) (U24)

• 批准号: 8538157
• 负责人: TATIANA M. FOROUD
• 金额: $ 15.6万
• 依托单位: INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-15 至 2016-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8538157
• 关键词: Advisory Committees; Affect; Age; Aliquot; Alzheimer' s Disease; Alzheimer' s disease risk; American; Biological; Biological Markers; Blood specimen; Brain; Cell Line; Cells; Clinical Data; Communities; Core Facility; DNA; DNA Library; DNA Sequence; Data; Data Coordinating Center; Dementia; Disease; Disease susceptibility; Enrollment; Ensure; Etiology; Family; Fostering; Frequencies; Funding; Future; Genetic; Genome; Genomics; Genotype; Goals; Human Resources; Indiana; Individual; Instruction; Lifting; Manuscripts; Measures; Meta-Analysis; Mission; National Institute on Aging; Onset of illness; Paper; Physicians; Plasma; Play; Positioning Attribute; Principal Investigator; Procedures; Protocols documentation; Publications; Qualifying; RNA; Recruitment Activity; Research; Research Personnel; Resources; Risk; Sampling; Secure; Solutions; Source; Specimen; Testing; Time; U-Series Cooperative Agreements; United States National Institutes of Health; Variant; Work; base; brain tissue; cell bank; data sharing; distributed data; exome; genome-wide; improved; meetings; new technology; prevent; programs; repository; research study; sample collection; success; tool

Program Director/Principal Investigator (Last, First, Middle): ForOUd, Tatiana, M. PROJECT SUMIVIARY (See instructions): The National Cell Repository for Alzheimer's Disease (NCRAD) plays a key role in the National Institute on Aging's (NIA) efforts to identify those at risk for Alzheimer disease (AD) and develop improved treatments to delay or prevent disease onset NCRAD was established as a cooperative agreement with the NIA to serve as the primary source of sample sharing for all NIA-funded dementia studies. Under the advisement of NIA and the Cell Bank Advisory Committee, it is the mission of NCRAD to remove critical bamers hindering reseach progress to understand the etiology of dementia. To achieve this goal, NCRAD has two primary functions: sample banking and sample distribution. NCRAD serves as a central repository banking samples from ongoing NIA funded studies using unifomn protocols with extensive quality measures. The type of samples being banked has expanded to include DNA, cell lines, plasma, serum, brain tissue and RNA. NCRAD works closely with the National Alzheimer Coordinating Center (NACC), another NIA core facility that serves as the data coordinating center for all the Alzheimer Disease Centers (ADCs). Together, NCRAD and NACC serve as key resources within the Alzheimer Disease Genetics Consortium (ADGC), coordinating the collection of samples from the 29 ADCs. NCRAD also widely distributes samples both to investigators for their own analyses as well as to central cores, where APOE genotyping, genomewide SNP arrays, and now whole genome and whole exome sequencing studies are performed. We propose to expand our successful efforts with the following specific aims; 1. To provide a state-of-the-art central biospecimen repository for all NIA-funded dementia studies that includes detailed standard operating procedures for the secure banking of DNA, cell lines, plasma, serum, RNA, and brain tissue. 2. To facilitate and foster sample sharing by distributing data and biospedmens to all qualified investigators for use in their research studies. RELEVANCE (See instructions): There are a number of barriers that hamper the ability of researchers to perform successful studies of Alzheimer disease and related dementias. These include the ability to share samples, access to large numbers of high quality samples and effective sharing of research results. NCRAD under the advisement of NIA and CBAC will lift these ban-iers and faciliate sample and data sharing among dementia researchers.

项目负责人/主要研究者（最后，第一，中间）：ForOUD，Tatiana，M。 项目概要（见说明）： 国家阿尔茨海默病细胞库（NCRAD）在国家研究所中发挥着关键作用。 NIA致力于识别阿尔茨海默病（AD）的风险并开发改进的治疗方法 为了延迟或预防疾病发作，NCRAD是作为与NIA的合作协议而建立的， 作为所有NIA资助的痴呆症研究的样本共享的主要来源。在...的主持下 NIA和细胞库咨询委员会，NCRAD的使命是消除阻碍 研究进展，以了解痴呆的病因。为了实现这一目标，NCRAD有两个主要的 功能：样品库和样品分发。 NCRAD作为一个中央储存库，储存来自正在进行的NIA资助研究的样本，使用unifomn 具有广泛质量措施的协议。样本库的类型已经扩展到包括DNA， 细胞系、血浆、血清、脑组织和RNA。NCRAD与国家阿尔茨海默病 协调中心（NACC），另一个NIA核心设施，作为所有 阿尔茨海默病中心（ADC）。NCRAD和NACC共同作为 阿尔茨海默病遗传学联盟（ADGC），协调从29个ADC收集样本。 NCRAD还将样本广泛分发给研究人员，供他们自己分析，并分发给中央研究机构。 核心，其中APOE基因分型，全基因组SNP阵列，现在全基因组和全外显子组 进行测序研究。我们建议通过以下具体措施扩大我们的成功努力 目的; 1.为所有由NIA资助的痴呆症研究提供最先进的中央生物标本库， 包括DNA、细胞系、血浆、血清 RNA和脑组织。 2.通过向所有合格的研究者分发数据和生物样本，促进和促进样本共享 用于他们的研究。 相关性（参见说明）： 有许多障碍阻碍了研究人员进行成功研究的能力。 阿尔茨海默病和相关痴呆症。其中包括共享样本的能力， 高质量的样本数量和有效的研究成果共享。NCRAD根据 NIA和CBAC将解除这些障碍，促进痴呆症研究人员之间的样本和数据共享。