2012 Meiosis Gordon Research Conference and Gordon Research Seminar

描述(由申请人提供)：2012年6月3-8日在新伦敦市科尔比-索耶学院举行的戈登研究会议(GRC)的一部分，请求部分资助一个关于减数分裂的国际会议。此外，还要求为减数分裂戈登研究研讨会(GRS)提供支持，该研讨会将在GRC之前的同一地点举行(2012年6月2日至3日)。GRS是一个为期1.5天的会议，由研究生和博士后研究员组织，它为初级研究人员提供了相互见面的机会，并被介绍到在为期41天半的减数分裂GRC期间将更深入地讨论的主题。这些会议的长期目标是了解在正常和疾病条件下减数分裂染色体分离和细胞分裂的基本机制。会议的具体目的是为这一跨学科领域的科学互动提供一个论坛，介绍该领域的最新成果，向该领域介绍年轻研究人员，促进年轻研究人员与知名研究人员之间的互动，并促进跨学科讨论，以促进新的方法、概念和想法。GRC将召集大约175名与会者，其中包括53名演讲者，讨论尖端的、主要是未发表的研究。该计划包括9个全体会议，广泛讨论当前的问题，包括同源重组、减数分裂进程的调节、细胞周期检查点、组蛋白修饰和减数分裂基因表达的控制、染色体配对和联会、姐妹染色单体凝聚力、减数分裂花束和核膜、染色体分离以及减数分裂和有性生殖的进化。四人会议将提供一个额外的论坛，对所有参与者开放。GRS将召集50-60名与会者，并将举行三次全体会议和一次海报会议。该应用程序与健康相关的是，减数分裂的错误至少导致了临床上公认的流产的一半，以及人类一系列染色体出生缺陷。程序性减数分裂双链断裂的修复为理解同源重组的机制和调控提供了一个很好的系统，同源重组是维持基因组稳定和预防癌症的有丝分裂细胞的重要过程。这次会议提供了一个讨论论坛，将增进我们对生殖健康这一基本方面的理解，并将提出推动未来研究所需的实验问题。 公共卫生相关性：减数分裂是一种进化上保守的、特化的细胞分裂，它产生配子(卵子或精子)用于有性繁殖。减数分裂过程中的染色体分离错误会产生染色体数目异常的配子，进而可能导致自发流产或发育障碍的个体。这次会议将提供一个讨论论坛，以增进对生殖健康的了解，并确定未来旨在了解正常减数分裂以及减数分裂细胞所犯错误的实验问题。

DESCRIPTION (provided by applicant): Partial support is requested for an international meeting on Meiosis as part of the Gordon Research Conferences (GRC) to be held at Colby-Sawyer College in New London, NH on June 3-8, 2012. In addition, support is requested for the Meiosis Gordon Research Seminar (GRS) that will be held in the same location, immediately prior to the GRC (June 2-3, 2012). The GRS is a 1.5 day meeting, organized by graduate students and postdoctoral fellows, which offers an opportunity for junior researchers to meet each other and be introduced to topics that will be covered in more depth during the 41/2-day Meiosis GRC. The long term goal of the meetings is to understand the fundamental mechanisms of meiotic chromosome segregation and cell division in both normal and disease conditions. The specific aims of the meeting are to provide a forum for scientific interaction in this interdisciplinary field, to present the newest results in the field, to introduce young researchers to the field, to promote interactions between young researchers with established investigators and to facilitate interdisciplinary discussions that will foster new approaches, concepts and ideas. The GRC will convene approximately 175 participants, including 53 speakers, to discuss cutting-edge, mostly unpublished research. The program comprises 9 plenary sessions that broadly address current issues in homologous recombination, regulation of meiotic progression, cell cycle checkpoints, histone modifications and control of meiotic gene expression, chromosome pairing and synapsis, sister chromatid cohesion, the meiotic bouquet and the nuclear envelope, chromosome segregation and the evolution of meiosis and sexual reproduction. Four poster sessions will provide an additional forum open to all participants. The GRS will convene between 50-60 participants and will have three plenary and one poster session. The health relatedness of the application is that errors in meiosis are responsible for at least half of clinically recognized miscarriages, as well as a spectrum of chromosomal birth defects in humans. Repair of programmed meiotic double strand breaks present an excellent system for understanding the mechanisms and regulation of homologous recombination, a process important in mitotically dividing cells for maintaining genome stability and preventing cancer. This meeting provides a forum for discussions that will advance our understanding of this fundamental aspect of reproductive health and that will frame the experimental questions necessary to drive future research. PUBLIC HEALTH RELEVANCE: Meiosis is an evolutionarily conserved, specialized cell division that creates gametes (eggs or sperm) used for sexual reproduction. Mistakes in chromosome separation during meiosis produce gametes with abnormal numbers of chromosomes that in turn can result in spontaneous abortions or individuals with developmental disabilities. This meeting will provide a forum for discussions that advance knowledge of reproductive health, and that define the future experimental questions aimed at understanding normal meiosis as well as the errors made by meiotic cells.