2012 Meiosis Gordon Research Conference and Gordon Research Seminar

描述（由申请人提供）：部分支持是要求国际会议减数分裂作为戈登研究会议（GRC）的一部分，将在科尔比索耶学院在新伦敦，NH在2012年6月3日至8日举行。此外，还要求支持将在同一地点举行的减数分裂戈登研究研讨会（GRS），就在GRC之前（2012年6月2日至3日）。GRS是一个为期1.5天的会议，由研究生和博士后研究员组织，为初级研究人员提供了一个相互见面的机会，并介绍了将在41/2天的减数分裂GRC期间更深入地讨论的主题。会议的长期目标是了解正常和疾病条件下减数分裂染色体分离和细胞分裂的基本机制。会议的具体目的是为这一跨学科领域的科学互动提供一个论坛，介绍该领域的最新成果，向年轻研究人员介绍该领域，促进年轻研究人员与知名研究人员之间的互动，并促进跨学科讨论，以促进新的方法、概念和想法。GRC将召集约175名与会者，其中包括53名发言人，讨论前沿，主要是未发表的研究。该计划包括9个全体会议，广泛解决同源重组，减数分裂进程的调节，细胞周期检查点，组蛋白修饰和减数分裂基因表达的控制，染色体配对和突触，姐妹染色单体凝聚力，减数分裂花束和核膜，染色体分离和减数分裂的进化和有性生殖的当前问题。四场海报会议将提供一个向所有与会者开放的额外论坛。GRS将召集50 - 60名与会者，并将举行三次全体会议和一次海报会议。该应用程序的健康相关性在于，减数分裂中的错误是至少一半临床公认的流产以及人类染色体出生缺陷的原因。程序性减数分裂双链断裂的修复为理解同源重组的机制和调控提供了一个极好的系统，同源重组是有丝分裂细胞中维持基因组稳定性和预防癌症的重要过程。这次会议提供了一个讨论论坛，将促进我们对生殖健康这一基本方面的理解，并将确定推动未来研究所需的实验问题。 公共卫生相关性：减数分裂是一种进化上保守的、特化的细胞分裂，产生用于有性生殖的配子（卵子或精子）。减数分裂期间染色体分离错误会产生染色体数目异常的配子，进而导致自然流产或发育障碍。本次会议将提供一个论坛，讨论促进生殖健康的知识，并确定未来的实验问题，旨在了解正常的减数分裂以及减数分裂细胞所犯的错误。

DESCRIPTION (provided by applicant): Partial support is requested for an international meeting on Meiosis as part of the Gordon Research Conferences (GRC) to be held at Colby-Sawyer College in New London, NH on June 3-8, 2012. In addition, support is requested for the Meiosis Gordon Research Seminar (GRS) that will be held in the same location, immediately prior to the GRC (June 2-3, 2012). The GRS is a 1.5 day meeting, organized by graduate students and postdoctoral fellows, which offers an opportunity for junior researchers to meet each other and be introduced to topics that will be covered in more depth during the 41/2-day Meiosis GRC. The long term goal of the meetings is to understand the fundamental mechanisms of meiotic chromosome segregation and cell division in both normal and disease conditions. The specific aims of the meeting are to provide a forum for scientific interaction in this interdisciplinary field, to present the newest results in the field, to introduce young researchers to the field, to promote interactions between young researchers with established investigators and to facilitate interdisciplinary discussions that will foster new approaches, concepts and ideas. The GRC will convene approximately 175 participants, including 53 speakers, to discuss cutting-edge, mostly unpublished research. The program comprises 9 plenary sessions that broadly address current issues in homologous recombination, regulation of meiotic progression, cell cycle checkpoints, histone modifications and control of meiotic gene expression, chromosome pairing and synapsis, sister chromatid cohesion, the meiotic bouquet and the nuclear envelope, chromosome segregation and the evolution of meiosis and sexual reproduction. Four poster sessions will provide an additional forum open to all participants. The GRS will convene between 50-60 participants and will have three plenary and one poster session. The health relatedness of the application is that errors in meiosis are responsible for at least half of clinically recognized miscarriages, as well as a spectrum of chromosomal birth defects in humans. Repair of programmed meiotic double strand breaks present an excellent system for understanding the mechanisms and regulation of homologous recombination, a process important in mitotically dividing cells for maintaining genome stability and preventing cancer. This meeting provides a forum for discussions that will advance our understanding of this fundamental aspect of reproductive health and that will frame the experimental questions necessary to drive future research. PUBLIC HEALTH RELEVANCE: Meiosis is an evolutionarily conserved, specialized cell division that creates gametes (eggs or sperm) used for sexual reproduction. Mistakes in chromosome separation during meiosis produce gametes with abnormal numbers of chromosomes that in turn can result in spontaneous abortions or individuals with developmental disabilities. This meeting will provide a forum for discussions that advance knowledge of reproductive health, and that define the future experimental questions aimed at understanding normal meiosis as well as the errors made by meiotic cells.