Impact of Psychosocial Stress on Time-to-Pregnancy

心理社会压力对怀孕时间的影响

• 批准号: 8553917
• 负责人: Germaine Louis
• 金额: $ 6.52万
• 依托单位: EUNICE KENNEDY SHRIVER NATIONAL INSTITUTE OF CHILD HEALTH & HUMAN DEVELOPMENT
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/8553917
• 关键词: Anxiety; Biological Markers; Clinical Trials Design; Conceptions; Control Locus; Data; Data Analyses; Enrollment; Feedback; Female; Fertility; Follow-Up Studies; Hydrocortisone; Measures; Mental Depression; Monitor; Moods; National Institute of Child Health and Human Development; Physiological; Pregnancy; Pregnancy Rate; Psychosocial Stress; Questionnaires; Randomized Clinical Trials; Research; Research Personnel; Role; Saliva; Salivary; Sampling; Social support; Stress; Time; Universities; Woman; alpha-amylase; arm; base; diaries; digital; instrument; pregnant; psychosocial; self esteem

NICHD is collaborating with Dr. Cecilia Pyper, Oxford University, to assess the impact of psychosocial stress on female fecundity as measured by time-to-pregnancy. Specifically, NICHD will build a stress component into Dr. Pypers currently ongoing Oxford Conception Study (OCS). The OCS is a three-arm randomized clinical trial designed to evaluate whether or not daily feedback from a digital fertility monitor increases the conception rate among women desiring pregnancy. Women enrolled in the OCS are followed for up to six months as they try to conceive. During this time, women send daily diary information, a mood questionnaire and data from their fertility monitor to the investigators on a monthly basis. Three-month and six-month cumulative pregnancy rates will be compared for the women in each of the three groups. NICHD has added a component to the Oxford Conception Study (OCS) with the expressed intent of measuring stress and its impact on female fecundity among newly enrolled women in the OCS (approximately 400 women). The NICHDs research objectives are: 1) to evaluate the effect of perceived psychosocial stress on time to pregnancy; 2) to evaluate the effect of physiologic stress on time to pregnancy; 3) to assess whether or not perceived psychosocial stress is associated with physiologic stress; and 4) to assess whether or not underlying anxiety and depression, social support, locus of control, or self-esteem confound or modify the relation between perceived psychosocial stress or physiologic stress and time-to-pregnancy. Saliva samples will be analyzed for two biomarkers of stress, viz., cortisol and alpha amylase. The Cohens Perceived Stress Scale will be used to measure perceived psychosocial stress. Several other psychosocial instruments will be administered at baseline to allow us to assess whether or not they confound or modify the relation between physiologic stress or perceived psychosocial stress and time-to-pregnancy. Data analysis has been completed for salivary biomarkers and TTP, and for psychosocial stress.

NICHD正在与牛津大学的塞西莉亚·派珀博士合作，以怀孕时间为衡量标准，评估心理社会压力对女性生育力的影响。具体地说，NICHD将在目前正在进行的牛津怀孕研究(OCS)中加入压力成分。OCS是一项三臂随机临床试验，旨在评估数字生育监测器的日常反馈是否会增加希望怀孕的女性的受孕率。登记参加OCS的妇女在试图怀孕期间被跟踪长达六个月。在此期间，妇女每月向调查人员发送每日日记信息、情绪问卷和生育监测仪的数据。将比较三组女性三个月和六个月的累积怀孕率。 NICHD在牛津怀孕研究(OCS)中增加了一个组成部分，目的是测量新加入牛津怀孕研究的妇女(约400名妇女)的压力及其对女性生育能力的影响。NICHD的研究目标是：1)评估感知到的心理社会压力对怀孕时间的影响；2)评估生理压力对怀孕时间的影响；3)评估感知到的心理社会压力是否与生理压力有关；以及4)评估潜在的焦虑和抑郁、社会支持、控制源或自尊是否混淆或改变了感知的心理社会压力或生理压力与怀孕时间之间的关系。唾液样本将被分析两个压力的生物标志物，即皮质醇和α-淀粉酶。Cohens感知压力量表将被用来测量感知到的心理社会压力。将在基线上使用其他几种心理社会工具，以使我们能够评估它们是否混淆或改变了生理压力或感知的心理社会压力与怀孕时间之间的关系。 唾液生物标记物和TTP以及心理社会压力的数据分析已经完成。

项目成果

Are increased levels of self-reported psychosocial stress, anxiety, and depression associated with fecundity?

• DOI: 10.1016/j.fertnstert.2012.05.018
• 发表时间: 2012-08-01
• 期刊: FERTILITY AND STERILITY
• 影响因子: 6.7
• 作者: Lynch, Courtney D.;Sundaram, Rajeshwari;Pyper, Cecilia
• 通讯作者: Pyper, Cecilia

Stress reduces conception probabilities across the fertile window: evidence in support of relaxation.

• DOI: 10.1016/j.fertnstert.2010.06.078
• 发表时间: 2011-06
• 期刊: FERTILITY AND STERILITY
• 影响因子: 6.7
• 作者: Louis, Germaine M. Buck;Lum, Kirsten J.;Sundaram, Rajeshwari;Chen, Zhen;Kim, Sungduk;Lynch, Courtney D.;Schisterman, Enrique F.;Pyper, Cecilia
• 通讯作者: Pyper, Cecilia