核心 D：神经病理学和动物行为-猫眼课题宝

核心 D：神经病理学和动物行为

批准号：

8292294

负责人：

ELIEZER MASLIAH

金额：

$10.02万

依托单位：

SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE

依托单位国家：

美国

项目类别：

财政年份：

2011

资助国家：

美国

项目状态：

已结题

起止时间：

2011-07-01 至 2013-06-30

来源：

https://reporter.nih.gov/project-details/8292294

关键词：

Alzheimer&apos s Disease Animal Behavior Animal Model Anterior Apoptosis Autopsy Behavioral Biochemical Biological Preservation Brain Brain Stem Brain region Cell model Characteristics Clinical Cognitive Complex Consensus Consultations Data Dementia Detergents Development Diagnosis Disease Drosophila genus Equilibrium Experimental Designs Freezing Fresh Tissue Genes Glial Fibrillary Acidic Protein Grant Guidelines Hippocampus (Brain)Housing Human Immunoblotting In Vitro Injection of therapeutic agent Investigation Laboratories Lentivirus Vector Lewy Body Disease Microtubule-Associated Protein 2 Mission Modeling Modification Molecular Motor Mus Mutation National Institute of Environmental Health Sciences Necrosis Neocortex Nerve Degeneration Neurons PTEN gene Parkinson Disease Parkinson&apos s Dementia Parkinsonian Disorders Pathogenesis Pathologic Pathway interactions Patients Pattern Performance Phosphorylation Phosphotransferases Platelet-Derived Growth Factor Play Principal Investigator Process Proteins RNA Research Research Support Role Saccharin Sampling Self Administration Staging Staining method Stains Synapses Synaptophysin Techniques Testing Time Tissues Transgenic Animals Transgenic Mice Tyrosine 3-Monooxygenase Visual alpha synuclein brain tissue calbindin density dopamine transporter embryonic stem cell human embryonic stem cell human tissue in vitro Model in vivo leucine-rich repeat kinase 2 motor learning mouse model mutant neocortical nerve stem cell neuropathology overexpression parkin gene/protein programs promoter protein aggregate protein misfolding protein protein interaction small molecule therapy development thioflavine tissue fixing

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The mission of the Neuropathology and Animal Behavior Core will be to provide the projects of the NIEHS Center with well-characterized autopsy brain material from human PD cases as well as with transgenic (tg) animal models expressing a-synuclein (a-syn), DJ-1, Parkin and PINK1 for neuropathological, molecular, biochemical and behavioral studies. The Core will provide support with human tissues from PD patients and animal models of PD to Projects 1, 2, and 3; support behavioral studies in Project 3; and help with survival/apoptosis/necrosis analysis of human embryonic stem cell (hESC)-derived developing neurons for Project 4. The Core has developed state of the art techniques for neuropathological analysis of neurodegeneration, biochemical analysis of misfolded protein accumulation, and behavioral analysis of motor and cognitive alterations. Moreover, we have developed unique animal models of PD in which to test and screen new molecular pathways and small molecules. Please note that a human clinical component, as defined in the NIEHS Center RFA, is contained within this Core.

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