Vector Biology Research and Integrated Vector Management For Malaria Control

疟疾控制的媒介生物学研究和综合媒介管理

• 批准号: 8319229
• 负责人: Martha Quinones
• 金额: $ 34.59万
• 依托单位: CAUCASECO SCIENTIFIC RESEARCH CENTER
• 依托单位国家: 美国
• 财政年份: 2011
• 资助国家: 美国
• 起止时间: 2011-07-01 至 2017-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8319229
• 关键词: Address; Affect; American; Americas; Anopheles Genus; Area; Behavior; Behavioral; Biology; Blood; Colombia; Competence; Complex; Country; Culicidae; Data; Development; Ecology; Effectiveness; Epidemiology; Future; Genetic; Goals; Guatemala; Human; Human Volunteers; Infection; Insecticides; Malaria; Maps; Measures; Membrane; Methods; Modeling; Mosquito Control; Needs Assessment; Oocysts; Outcomes Research; Panama; Parasites; Pattern; Peru; Plasmodium falciparum; Population; Probability; Procedures; Process; Relative (related person); Research; Residual state; Resistance; Risk; Sampling; Site; Sporozoites; Techniques; Testing; Uncertainty; Variant; anthropogenesis; base; density; design; environmental change; evidence base; experience; feeding; fight against; improved; member; molecular marker; operation; programs; research study; response; success; tool; transmission process; vector; vector control; vector management strategies

Successful malaria control and eventual eliminafion in the non-Amazonian region of Lafin America requires effective control of Anopheles mosquitoes that serve as malaria vectors. Each country of this ICEMR networic, Colombia, Guatemala, Panama, and Peru, has a National Malaria Control Program (NMCP) that features vector control. However, effecfiveness is limited by insufficient informafion on species of Anopheles mosquitoes that serve as malaria vectors, uncertainties regarding the impact of anthropogenic environmental changes on the dynamics of malaria parasite transmission, limited effective tools for vector control, and incompletely developed integrated vector management (IVM) components of NMCPs. The goal of this project is to address major gaps in our understanding of the ecology, behavior, vector potenfial, and control of Anopheles malaria vectors to guide the development and implementation of more effective IVM strategies of NMCPs. Based on extensive preliminary data and experience of team members representing academic institufions and NMCPs in each country within this ICEMR network, priorifies for research focus on key scientific questions that have a direct bearing on the future success of vector control operafions. This project includes 3 specific aims: 1) invesfigate the ecology, behavior, and malaria parasite transmission potential of malaria vector species to identify key factors that would facilitate more effective targeted vector control, 2) determine how known and suspected malaria vector species from each country in the ICEMR network differ in their innate vector competence for Plasmodium falciparum and P. vivax, and 3) assess the efficacy of current vector control operafions of NMCPs and conduct mulfi-country field trials of new vector control products that may strengthen capacifies of NMCPs to implement effective IVM strategies for vector control, In partnership with NMCPs, the ICEMR team will demonstrate the translafional value of research outcomes for improving vector control in ecologically diverse areas o f t he non-Amazonian region through an iterafive process of strengthening and evaluating IVM components of NMCPs.

成功控制疟疾并最终在非亚马逊地区的拉芬美洲消灭疟疾需要 有效控制作为疟疾媒介的按蚊。本ICEMR的每个国家 尼加拉瓜、哥伦比亚、危地马拉、巴拿马和秘鲁的国家疟疾控制方案， 功能矢量控制。但由于按蚊种类资料不足，其有效性受到限制 作为疟疾病媒的蚊子，人类活动影响的不确定性， 环境变化对疟原虫传播动力学的影响， 控制，以及国家重点控制项目的病媒综合管理部分未完全开发。 该项目的目标是解决我们对生态学，行为，媒介 疟疾病媒按蚊的控制，以指导制定和实施更多的 有效的病媒综合管理战略。基于大量的初步数据和团队成员的经验 代表ICEMR网络内每个国家的学术机构和NMCP，优先考虑 研究重点是对今后病媒控制的成功有直接影响的关键科学问题 操作。 该项目包括3个具体目标：1）调查生态、行为和疟原虫传播 疟疾病媒物种在确定有助于更有效地定向病媒的关键因素方面的潜力 控制，2）确定ICEMR中每个国家的已知和疑似疟疾病媒物种 网络在它们对恶性疟原虫和间日疟原虫的先天载体能力方面不同，以及3）评估 目前国家主要控制方案病媒控制工作效力和对新病媒进行多国实地试验 可加强国家监测和预防中心执行有效病媒病媒综合防治战略的能力的控制产品 ICEMR团队将与NMCP合作，展示研究的商业价值 在非亚马逊地区生态多样性地区通过一项 加强和评价国家监测项目病媒综合防治组成部分的迭代进程。