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Vector Biology Research and Integrated Vector Management For Malaria Control

疟疾控制的媒介生物学研究和综合媒介管理

基本信息

批准号：
9099696
负责人：
Martha Quinones
金额：
$ 18.24万
依托单位：
CAUCASECO SCIENTIFIC RESEARCH CENTER
依托单位国家：
美国
项目类别：
财政年份：
资助国家：
美国
起止时间：
至 2018-06-30
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9099696
关键词：
Address Affect Anopheles Genus Area Behavior Biology Bite Blood Colombia Competence Complex Country Cross-Sectional Studies Culicidae Data Development Ecology Effectiveness Epidemiology Formulation Future Generations Genetic Goals Guatemala Human Human Volunteers Infection Insecticide Resistance Insecticides Institution Investigation Latin America Latin American Malaria Maps Measures Membrane Methods Modeling Mosquito Control Needs Assessment Oocysts Outcomes Research Panama Parasites Pattern Peru Plasmodium falciparum Plasmodium vivax Population Practice Management Probability Procedures Process Research Research Priority Residual state Risk Sampling Site Sporozoites Techniques Testing Uncertainty Variant base behavioral response density design evidence base experience feeding fight against improved outcome malaria infection man made change member molecular marker operation programs research study response success tool transmission process vector vector control vector management strategies

项目摘要

Successful malaria control and eventual elimination in the non-Amazonian region of Latin America requires effective control of Anopheles mosquitoes that serve as malaria vectors. Each country of this ICEMR network, Colombia, Guatemala, Panama, and Peru, has a National Malaria Control Program (NMCP) that features vector control. However, effectiveness is limited by insufficient information on species of Anopheles mosquitoes that serve as malaria vectors, uncertainties regarding the impact of anthropogenic environmental changes on the dynamics of malaria parasite transmission, limited effective tools for vector control, and incompletely developed integrated vector management (IVM) components of NMCPs. The goal of this project is to address major gaps in our understanding of the ecology, behavior, vector potential, and control of Anopheles malaria vectors to guide the development and implementation of more effective IVM strategies of NMCPs. Based on extensive preliminary data and experience of team members representing academic institutions and NMCPs in each country within this ICEMR network, priorities for research focus on key scientific questions that have a direct bearing on the future success of vector control operations. This project includes 3 specific aims: 1) investigate the ecology, behavior, and malaria parasite transmission potential of malaria vector species to identify key factors that would facilitate more effective targeted vector control, 2) determine how known and suspected malaria vector species from each country in the ICEMR network differ in their innate vector competence for Plasmodium falciparum and P. vivax, and 3) assess the efficacy of current vector control operations of NMCPs and conduct multi-country field trials of new vector control products that may strengthen capacities of NMCPs to implement effective IVM strategies for vector control, In partnership with NMCPs, the ICEMR team will demonstrate the translational value of research outcomes for improving vector control in ecologically diverse areas o f t he non-Amazonian region through an iterative process of strengthening and evaluating IVM components of NMCPs.

要在拉丁美洲非亚马逊地区成功控制和最终消灭疟疾，就必须有效控制作为疟疾病媒的按蚊。ICEMR网络的每个国家，哥伦比亚、危地马拉、巴拿马和秘鲁，都有一个以病媒控制为特点的国家疟疾控制方案。然而，由于关于作为疟疾病媒的按蚊种类的信息不足、人为环境变化对疟原虫传播动态的影响不确定、病媒控制的有效工具有限以及国家监测和预防方案的病媒综合管理组成部分未完全开发，有效性受到限制。该项目的目标是解决我们在了解按蚊疟疾病媒的生态、行为、病媒潜力和控制方面的主要差距，以指导制定和实施更有效的NMCP病媒综合防治战略。根据代表该委员会网络内各国学术机构和国家监测和控制方案的小组成员的大量初步数据和经验，研究的重点是对今后病媒控制行动的成功有直接影响的关键科学问题。该项目包括三个具体目标：1）调查疟疾病媒物种的生态、行为和疟疾寄生虫传播潜力，以确定有助于更有效的有针对性的病媒控制的关键因素，2）确定ICEMR网络中每个国家的已知和疑似疟疾病媒物种在其对恶性疟原虫和间日疟原虫的先天病媒能力方面有何不同，以及3）评估国家监测和控制缔约方目前病媒控制行动的效力，并对新的病媒控制产品进行多国实地试验，以加强国家监测和控制缔约方实施有效病媒综合防治战略的能力。ICEMR小组将展示研究成果在改善生态多样性地区的病媒控制方面的转化价值，通过加强和评价国家监测方案病媒综合管理组成部分的迭接进程，在亚马孙地区开展了一项活动。