Data Management

数据管理核心（DMC）将负责为所有人提供全面的数据和信息支持。 方案的组成部分。该计划中提出的研究是一个非常有价值的来源， 这些数据对艾滋病毒疫苗的开发至关重要。建立一个机制，协调收集 跨多个站点的公共关键数据元素可以促进这种协作， 这是一个重要的机会，可以利用资源，加快科学发现的步伐， 有效的预防艾滋病毒疫苗的基础上了解体液反应。我们致力于发展和 实施联合收割机数据所需的基础设施，并在两个成功的研究领域协调研究工作。 UCSD（首选计划）和国际艾滋病疫苗倡议（IAVI）的主要艾滋病病毒感染队列 议定书C）。其目的不仅仅是建立一个综合数据库，而是使数据管理标准化， 检索程序的问题，如艾滋病毒的危险行为，急性艾滋病毒的症状，抗体检测数据， 分期标准、治疗史和临床结果。传统数据库解决方案不必要地阻碍了 调查人员查询和分析多方面的丰富数据源。这种接触将大大 促进合作调查，以及数据探索，假设生成和发现。 还将制定和实施质量保证程序，以确保综合数据 干净、可靠、随时可供分析。此外，DMC将制定并实施程序 管理所提议的B单元项目之间生成和共享的数据所必需的 HIV-1疫苗发现免疫学合作计划，简称“计划” 在整个核心描述中。我们建议设计和开发一个完全开源的，可移植的， 一个低维护的软件解决方案，以进行一些共同的信息技术（IT）和数据 收集、生成和分析计划相关数据的任何合作者所需的分析任务。

The Data Managennent Core (DMC) will be responsible for overall data and information support for all components of the Program. The studies proposed in the Program represent a critically valuable source of data important for the development of an HIV vaccine. Developing a mechanism to coordinate collection of common key data elements across multiple sites can facilitate such collaboration and represents an important opportunity to leverage resources and accelerate the pace of scientific discovery concerning an effective preventative HIV vaccine based on understanding the humoral response. We aim to develop and implement the infrastructure needed to combine data and coordinate research efforts across two successful primary HIV infection cohorts at UCSD (First Choice Program) and International AIDS Vaccine Initiative (lAVI Protocol C). The aim is not simply to create a combined database, but to standardize data management and retrieval procedures for issues such as HIV risk behavior, symptoms of acute HIV, antibody testing data, staging criteria, treatment history, and clinical outcomes. Legacy database solutions unnecessarily hinder investigators from querying and analyzing multi-faceted rich data sources. Such access will substantially facilitate collaborative investigations, as well as data exploration, hypothesis generation and discovery. Quality assurance procedures will also be developed and implemented to insure that combined data is cleaned, reliable, and ready for analysis. Additionally, the DMC will develop and implement the procedures necessary to manage the data generated and shared across the projects of the proposed, B Cell Immunology Partnership Program For HIV-1 Vaccine Discovery, which will be referred to as the "Program" throughout this Core description. We propose to design and develop a completely open source, portable and low-maintenance software solution to carry out a number of common information technology (IT) and data analysis tasks required by any collaborator who collects, generates and analyzes Program related data.