Data Management

数据管理核心(DMC)将负责为所有用户提供总体数据和信息支持 该计划的组成部分。该方案中提出的研究是一个极其有价值的来源 对开发艾滋病毒疫苗很重要的数据。建立协调收集工作的机制 跨多个站点的公共关键数据元素可以促进此类协作，并代表 利用资源和加快科学发现步伐的重要机会 基于对体液反应的了解，有效的预防性艾滋病毒疫苗。我们的目标是开发和 实施整合数据和协调研究工作所需的基础架构 UCSD(首选计划)和国际艾滋病疫苗倡议(LAVI)的主要艾滋病毒感染队列 协议C)。其目标不是简单地创建一个组合数据库，而是标准化数据管理和 针对诸如艾滋病毒危险行为、急性艾滋病毒症状、抗体检测数据、 分期标准、治疗历史和临床结果。旧式数据库解决方案不必要地阻碍了 来自调查人员的查询和分析多方面的丰富数据来源。这样的访问将在很大程度上 促进协作调查，以及数据探索、假设生成和发现。 还将制定和实施质量保证程序，以确保合并的数据 清洁、可靠，可供分析。此外，公契将制定和实施这些程序 需要管理在建议的B单元的项目中生成和共享的数据 HIV-1疫苗发现的免疫学伙伴计划，将被称为

The Data Managennent Core (DMC) will be responsible for overall data and information support for all components of the Program. The studies proposed in the Program represent a critically valuable source of data important for the development of an HIV vaccine. Developing a mechanism to coordinate collection of common key data elements across multiple sites can facilitate such collaboration and represents an important opportunity to leverage resources and accelerate the pace of scientific discovery concerning an effective preventative HIV vaccine based on understanding the humoral response. We aim to develop and implement the infrastructure needed to combine data and coordinate research efforts across two successful primary HIV infection cohorts at UCSD (First Choice Program) and International AIDS Vaccine Initiative (lAVI Protocol C). The aim is not simply to create a combined database, but to standardize data management and retrieval procedures for issues such as HIV risk behavior, symptoms of acute HIV, antibody testing data, staging criteria, treatment history, and clinical outcomes. Legacy database solutions unnecessarily hinder investigators from querying and analyzing multi-faceted rich data sources. Such access will substantially facilitate collaborative investigations, as well as data exploration, hypothesis generation and discovery. Quality assurance procedures will also be developed and implemented to insure that combined data is cleaned, reliable, and ready for analysis. Additionally, the DMC will develop and implement the procedures necessary to manage the data generated and shared across the projects of the proposed, B Cell Immunology Partnership Program For HIV-1 Vaccine Discovery, which will be referred to as the