The Relationship Between Obesity and Falling in Older Adults

肥胖与老年人跌倒之间的关系

• 批准号: 8303752
• 负责人: Angela Gayle Fowler-Brown
• 金额: $ 21.75万
• 依托单位: BETH ISRAEL DEACONESS MEDICAL CENTER
• 依托单位国家: 美国
• 财政年份: 2012
• 资助国家: 美国
• 起止时间: 2012-04-15 至 2014-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8303752
• 关键词: Acute; Address; Adult; Affect; Age; Aging; Attention; Bone Density; Cessation of life; Chronic Disease; Clinical; Comorbidity; Complex; Conflict (Psychology); Data; Data Set; Demographic Factors; Elderly; Ethnic Origin; Event; Expenditure; Fall prevention; Gait; Generations; Goals; Health; Health Care Costs; High Prevalence; Impairment; Incidence; Injury; Intervention; Investigation; Knowledge; Lead; Mediating; Medical; Mental Depression; Morbidity - disease rate; Musculoskeletal Equilibrium; Non obese; Obesity; Older Population; Outcome; Pain; Patients; Pharmaceutical Preparations; Physical Function; Physical activity; Population; Prevalence; Public Health; Quality of life; Race; Recovery; Relative (related person); Retirement; Risk; Risk Assessment; Risk Factors; Series; Severities; Shapes; Socioeconomic Status; Surveys; Weight; Woman; Work; aged; aging population; chronic depression; cost; design; disability; economic cost; equilibration disorder; experience; fall risk; falls; functional loss; high risk; human old age (65+); interest; low socioeconomic status; medical complication; men; modifiable risk; novel; novel strategies; obesity risk; physical conditioning; prospective; response; sex; skeletal; weight loss intervention

DESCRIPTION (provided by applicant): Obesity is a complex condition that can affect several facets of functioning. Previous studies have found that obesity is associated with a higher prevalence of several chronic disease conditions, lower quality of life and impaired mobility in older adults. However, one component of physical functioning that has not been well studied in relationship to obesity is risk of falls. Falls and injuries related to falling are a very importan health concern in the older population. Falls can result in significant morbidity, loss of functionl independence and death. On a societal level, injuries related to falls contribute substantially to health care costs, leading to billions of dollars of expenditures each year. Although both obesity and falls are very prevalent conditions in older adults, there is very limited understanding as to how these two conditions may interact. Interestingly, there are a number of potential mechanisms through which obesity could influence the risk of falls. Prior work has identified several patient-related risk factors for falls in older adults including mobility and balance impairment, pain, depression, chronic medical conditions and physical inactivity. Previous work has also shown that obesity is associated with increased mobility and balance impairment, pain, depression, chronic medical conditions and physical inactivity. While there are multiple plausible mechanisms through which obesity could increase the risk of falling, there have been surprisingly few studies of how these two health conditions interact. Further, the studies that are available are largely cross-sectional and provide conflicting results. A deeper understanding of how obesity and falling interact would allow better identification of seniors at risk for falls, an could potentially lead to novel strategies to prevent falls. The studies proposed herein are designed to use a large, nationally representative dataset to prospectively examine whether obesity is associated with increased risk of falls, and to study which clinical factors may mediate this relationship. We will also explore whether this relationship is modified by factors such as sex, race/ethnicity, and socioeconomic status. We will then use another nationally representative dataset to analyze whether the medical costs associated with fall injuries are different in obese vs. the non-obese. The knowledge gained from the proposed work will allow for better understanding of the impact of obesity on the lives of older adults and permit better informed public health response to the health needs of an aging, obese population. PUBLIC HEALTH RELEVANCE: The proposed work will prospectively examine the relationship between obesity and risk of falls in older adults. We will then examine whether there are clinical factors that might explain the relationship between obesity and risk of falls. Finally we will study whether health care costs related to fall injuries differ in the obese vs. the non-obese.

描述（由申请人提供）：肥胖是一种复杂的疾病，可以影响功能的几个方面。先前的研究发现，肥胖与老年人中几种慢性疾病的患病率较高、生活质量较低和活动能力受损有关。然而，身体功能的一个组成部分，尚未得到很好的研究，在关系到肥胖是风险的福尔斯。福尔斯和与跌倒有关的伤害是老年人非常重要的健康问题。福尔斯可导致显著的发病率、功能独立性的丧失和死亡。在社会层面上，与福尔斯跌倒相关的伤害大大增加了医疗保健费用，导致每年数十亿美元的支出。虽然肥胖和福尔斯都是老年人非常普遍的情况，但对这两种情况如何相互作用的了解非常有限。有趣的是，有许多潜在的机制可以通过肥胖影响福尔斯的风险。先前的工作已经确定了老年人福尔斯的几个与患者相关的风险因素，包括移动和平衡障碍、疼痛、抑郁、慢性疾病和身体活动不足。以前的研究也表明，肥胖与增加的流动性和平衡障碍，疼痛，抑郁症，慢性疾病和身体活动不足有关。虽然有多种合理的机制可以使肥胖增加跌倒的风险，但令人惊讶的是，关于这两种健康状况如何相互作用的研究很少。此外，这些研究 现有的主要是横截面的，并提供相互矛盾的结果。更深入地了解肥胖和跌倒如何相互作用将有助于更好地识别有福尔斯风险的老年人，并可能导致预防福尔斯的新策略。本文提出的研究旨在使用一个大型的、具有全国代表性的数据集来前瞻性地检查肥胖是否与福尔斯风险增加相关，并研究哪些临床因素可能介导 这种关系我们还将探讨这种关系是否受到性别，种族/民族和社会经济地位等因素的影响。然后，我们将使用另一个具有全国代表性的数据集来分析肥胖与非肥胖人群中与跌倒受伤相关的医疗费用是否不同。从拟议的工作中获得的知识将有助于更好地了解肥胖对老年人生活的影响，并允许更好地了解公共卫生应对老龄化肥胖人口的健康需求。 公共卫生相关性：拟议的工作将前瞻性地研究肥胖与老年人福尔斯跌倒风险之间的关系。然后，我们将研究是否有临床因素可以解释肥胖和福尔斯风险之间的关系。最后，我们将研究肥胖者和非肥胖者与跌倒受伤相关的医疗费用是否不同。